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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Diabetes-and nondiabetes-Related Lower Extremity Amputation Incidence Before and After the Introduction of Better Organized Diabetes Foot Care:Continuous longitudinal monitoring using a standard method显示文摘 | Ronan J N igel C V illiam F | 2008 | Diabetes Care2008，31，5： | 1 |
| 3 | Broadband tissue-equivalent phantom for BAN applications at millimeter wavesm 显示文摘 | Nacer C Maxim Z Ronan S | 2012 | IEEE Transactions on Microwave Theory and Techniques2012，60，7： | 1 |
| 4 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova D K Clelland C Ronan J | 2004 | Respiratory Medicine2004，98，： | 1 |
| 5 | Measurement of phthalates diesters in food using gas chromatography-tandem mass spectrometry显示文摘 | RONAN C FREDERIC L FABRICE M | 2016 | Food Chem2016，196，： | 1 |
| 6 | Diabetes-and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care : Continuous longitudinal monitoring using a standard method 显示文摘 | Ronan J Nigel C Villiam F | 2008 | Diabetes Care2008，31，3： | 1 |
| 7 | Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase显示文摘 | Dichek HL Parrott C Ronan R | 1993 | J Lipid Res1993，34，8： | 1 |
| 8 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova D K Clelland C Ronan J | 2004 | Respir Med2004，98，2： | 1 |
| 9 | New muhiersidue analytical method dedicated to trace level measurement of borminated flameretardants in human biological matrices 显示文摘 | RONAN C JEAN P A PHILIPPE M | 2005 | J Chonnatogr A2005，1100，： | 1 |
| 10 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova DK Clelland C Ronan J | 2004 | Respir Med2004，98，： | 1 |
| 11 | Muhifunctional, high- level cytokine-producing Thl ceils in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice 显示文摘 | Forbes EK Sander C Ronan EO | 2008 | J Immunol2008，181，7： | 1 |
| 12 | Controlled acceleration of GeV electron beams in an all-optical plasma waveguide显示文摘Laser-plasma accelerators(LPAs)produce electric fields of the order of 100 GV m-1,more than 1000 times larger than those produced by radio-frequency accelerators.These uniquely strong fields make LPAs a promising path to generate electron beams beyond the TeV,an important goal in high-energy physics.Yet,large electric fields are of little benefit if they are not maintained over a long distance.It is therefore of the utmost importance to guide the ultra-intense laser pulse that drives the accelerator.Reaching very high energies is equally useless if the properties of the electron beam change completely from shot to shot,due to the intrinsic lack of stability of the injection process.State-of-the-art laser-plasma accelerators can already address guiding and control challenges separately by tweaking the plasma structures.However,the production of beams that are simultaneously high quality and high energy has yet to be demonstrated.This paper presents a novel experiment,coupling laser-plasma waveguides and controlled injection techniques,facilitating the reliable and efficient acceleration of high-quality electron beams up to 1.1 GeV,from a 50 TW-class laser. | Kosta Oubrerie Adrien Leblanc Olena Kononenko Ronan Lahaye Igor A.Andriyash Julien Gautier Jean-Philippe Goddet Lorenzo Martelli Amar TafziKim Ta Phuoc Slava Smartsev Cédric Thaury | 2022 | Light(Science & Applications)2022，11，7： | 1 |
| 13 | Field study and simulation of diurnal temperature effects of infiltration and variable saturated flow beneath an ephemeral stream 显示文摘 | Ronan A D Prudic D E Thodal C E | 1998 | Journal of Hydrology1998，302，： | 1 |
| 14 | Acidic fibroblast growthfactor accelerates dermal wound healing in diabetic mice 显示文摘 | Mellin TN C ashen DE Ronan JJ | 1995 | J InestDermatol1995，104，5： | 1 |
| 15 | Effect of maturity and storage conditions on R rishiatin accumulation and disease resistance to botrytis cinerea in UV-C treated tomato fruit显示文摘 | Marie T C Ronan C Dominique R | 2003 | Acta Horticulture2003，599，： | 1 |
| 16 | A spice ii subcircuit representation for power mosfets using empirical methods显示文摘 | Dolny G M Ronan J H R Wheatley J C F | | 0，，： | 1 |
| 17 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova DK Clelland C Ronan J | 2004 | Respir Med2004，98，： | 1 |
| 18 | An adapter ligation-mediated PCR method for high-throughput mapping of T-DNA inserts in the Arabidopsis genome显示文摘 | Ronan C O Jose M A Christopher J K | 2007 | Nature Protocols2007，2，11： | 1 |
| 19 | A new chemically defined medium for wine lactic acid bacteria显示文摘 | Nicolas T Ronan N Romain C | 2009 | Food Research International2009，42，3： | 1 |
| 20 | Parathormone response to thyroid surgery显示文摘 | Ronan AC Regina H Seamus C | 2006 | AM J SURG2006，191，4： | 1 |
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