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| 1 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 2 | Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients显示文摘 | Giuseppe Marazzi Luca Cacciotti Francesco Pelliccia Luigi Iaia Maurizio Volterrani Giuseppe Caminiti Barbara Sposato Rosalba Massaro Fabrizia Grieco Giuseppe Rosano | 2011 | Advances in Therapy2011，，12： | 2 |
| 3 | A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: A multicenter evaluation显示文摘 | Stacey J. Wieczorek Alan H.B. Wu Robert Christenson Padma Krishnaswamy Stephen Gottlieb Thomas Rosano David Hager Nancy Gardetto Albert Chiu Kathryn R. Ba illy Alan Maisel | 2002 | American Heart Journal2002，，5： | 2 |
| 4 | 17 beta-estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men wifth coronaryheart disease显示文摘 | Rosano GM Sarrel PM | 1995 | Circulation1995，92，： | 1 |
| 5 | Toward a unified model of the action of CLP/HSP100 chaperones in chloroplasts 显示文摘 | Rosano GL Bruch EM Colombo CV | 2012 | Plant sighaling Behavior2012，7，6： | 1 |
| 6 | Norepinephrine and metaraminol in septic shock: a comparison of the hemodynamic effects 显示文摘 | Natalini G Schivalocchi V Rosano A | 2005 | Intensive Care Med2005，31，5： | 1 |
| 7 | Low testosterone levels are associated with coronary artery disease in male patients with angina显示文摘 | Rosano GM Sheiban I Massaro R | 2007 | Int J Impot Res2007，19，2： | 1 |
| 8 | Effects of the freeze-thaw process on a -amylase显示文摘 | WHITTAM J H ROSANO H L | 1973 | Cryobiology1973，10，3： | 1 |
| 9 | Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy显示文摘 | Giuseppe Marazzi Otavio Gebara Cristiana Vitale Giuseppe Caminiti Mauricio Wajngarten Maurizio Volterrani José A. F. Ramires Giuseppe Rosano Massimo Fini | 2009 | Advances in Therapy2009，，4： | 1 |
| 10 | Cardiovascular health in the menopausal woman:impact of the timing of hor-mone replacement therapy 显示文摘 | Rosano G Vitale C Spoleti'ni I | 2012 | Climacteric2012，15，15： | 1 |
| 11 | Acute anti-ischemic effect of testosterone in men with coronary artery disease显示文摘 | LEONARDO F PAGNOTTA P | 1999 | Circulation1999，99，： | 1 |
| 12 | Emerging role of the endothelin axis in ovarian tumor progression显示文摘 | Bagnato A Spinella F Rosano L | 2005 | Endocr Relat Cancer2005，12，4： | 1 |
| 13 | Maxillary sinus septa prevalence and anatomy 显示文摘 | Rosano G Gaudy JF Chaumanet G | 2012 | Rev Stomatol Chir Maxillofac2012，113，1： | 1 |
| 14 | Standard laryngeal mask airway and LMA-Proseal during laparoscopic surgery显示文摘 | Natalini G Lanza G Rosano A | | 0，，06： | 1 |
| 15 | Recombinant protein expression in Escherichia coli : advances and challenges 显示文摘 | Rosano GL Ceccarelli EA | 2014 | Front Microbiol2014，5，： | 1 |
| 16 | Infant mortality and congenital anomalies from 1950 to 1994:an international perspective显示文摘 | Rosano A Botto LD Botting B | | 0，，09： | 1 |
| 17 | Type 2 diabetes and cognitive impairment: contributions from neuroimaging 显示文摘 | John P David F Caterina Rosano | 2014 | J Geriatr Psychiatry Neurol2014，27，1： | 1 |
| 18 | Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo显示文摘 | Salani D Taraboletti G Rosano L | 2000 | Am J Pathol2000，157，5： | 1 |
| 19 | Endothelin-1 Induces Vascular Endothelial Growth Factor by Increasing Hypoxia-inducible Factor-1alpha in Ovarian Carcinoma Cells显示文摘 | SPINELLA F ROSANO L DICASTRO V | 2002 | J Biol Chem(S0021-9258)2002，277，27： | 1 |
| 20 | Endotheline-1 induces an angiogensic pheenotype in cultured endothelial cells and stimulates neovascularization in vivo 显示文摘 | Salani D Taraboletti G Rosano L | 2000 | Am J Pathol2000，157，5： | 1 |
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