|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway显示文摘5-Fluorouracil (5-FU) resistance has been long considered as an obstacle to the efficacy of chemotherapy in colorectal cancer (CRC). In this study, we demonstrated the role of miR-20b-5p-regulated syndecan-2 (SDC2) in 5-FU resistance of CRC cells. 5-FU-resistant SW480 CRC cells were established by treatment of SW480 cells with stepwise increase of 5-FU concentration. The results showed that SDC2 was expressed significantly higher in SW480/5-FU cells than in SW480/WT cells as revealed by quantitative real-time polymerase chain reaction and western blot analysis. MTT assay and BrdU assay showed that SDC2 overexpression led to increased cell survival rate, while SDC2 knockdown reversed the drug resistance of SW480/5-FU cells. Wound healing and transwell invasion assays revealed that knockdown of SDC2 inhibited the migratory and invasive ability of SW480/5-FU cells. Moreover, animal experiments indicated that si-SDC2 plays a suppressive role in tumor growth in vivo. We also confirmed that miR-20b-5p interacted with SDC2, which reversed the effect of SDC2 in SW480/5-FU cells via the c-Jun N-terminal kinase (JNK)/extracellular regulated protein kinases (ERK) signaling pathway. These findings showed that JNK/ERK signaling pathway is involved in miR-20b-5p/SDC2 axis-mediated 5-FU resistance in SW480/5-FU cells, indicating that the miR-20b-5p/SDC2 axis is a potential target for reversing 5-FU resistance in CRC. | Ruheng Hua Yan Zhang Xiyue Yan Dong Tang Xiaolong Li Qingfeng Ni Daorong Wang Jianwei Zhu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 4 |
| 2 | Effects of temperature and strain rate on dynamic properties of concrete显示文摘 | Bin Jia Junlin Tao Zhengliang Li Ruheng Wang Yu Zhang | 2008 | Transactions of Tianjin University2008，，1： | 1 |
| 3 | A Study on Nanoscale Infrared Absorbent Working in Waveband Range of 1300-400 cm^(-1)显示文摘Nanoscale powder of SiO_2/Al_2O_3/TiO_2 composite was prepared by sol-gel method.Microstructure and mor- phology of the obtained samples were characterized by infrared(IR),X-ray diffraction(XRD)analysis and transmission electron microscopy(TEM).It is proved that infrared absorbing peaks of the samples are in waveband range of 1300-400 cm^(-1),and the peak shape changes with their component.Mechanism of the in- frared peak's positions and shapes which changes with the size and morphology of the prepared nano-particles has been tentatively discussed. | Yongmao HU Jinzhong XIANG Xueqing ZHANG Ruheng LI Xinghui WU | 2008 | Journal of Materials Science & Technology2008，24，5： | 1 |
| 4 | A Multi-level En- gineering Talents Cultivating System 显示文摘 | Xie Yong Ha Jincheol Li Ruheng | 2012 | Journal of Engi- neering Education Research2012，15，4： | 1 |
| 5 | A Cu-modified active carbon fiber significantly promoted H_(2)S and PH_(3) simultaneous removal at a low reaction temperature显示文摘Poisonous gases,such as H_(2)S and PH3,produced by industrial production harm humans and damage the environment.In this study,H_(2)S and PH3 were simultaneously removed at low temperature by modified activated carbon fiber(ACF)catalysts.We have considered the active metal type,content,precursor,calcination,and reaction temperature.Experimental results exhibited that ACF could best perform by loading 15%Cu from nitrate.The optimized calcination temperature and reaction temperature separately were 550℃ and 90℃.Under these conditions,the most removal capacity could reach 69.7 mg/g and 132.1 mg/g,respectively.Characterization results showed that moderate calcination temperature(550℃)is suitable for the formation of the copper element on the surface of ACF,lower or higher temperature will generate more cuprous oxide.Although both can exhibit catalytic activity,the role of the copper element is significantly greater.Due to the exceptional dispersibility of copper(oxide),the ACF can still maintain the advantages of larger specific surface area and pore volume after loading copper,which is the main reason for better performance of related catalysts.Finally,increasing the copper loading amount can significantly increase the crystallinity and particle size of copper(oxide)on the ACF,thereby improving its catalytic performance.In situ IR found that the reason for the deactivation of the catalyst should be the accumulation of generated H_(2)PO_(4)^(-) and S0_(4)^(2-)(H_(2)0)^(6) which could poison the catalyst. | Yingwu Wang Ping Ning Ruheng Zhao Kai Li Chi Wang Xin Sun Xin Song Qiang Lin | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员