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| 1 | Fast synthesis of monodisperse TiO_2 submicrospheres via a modified sol-gel approach显示文摘Monodisperse titania glycolate submicrospheres were synthesized by a modified sol-gel route, in which ultrasonic treatment was introduced to improve the reaction efficiency. The as-prepared products were characterized by means of Fourier transform infrared spectrum (FT-IR), transmission electron microscopy (TEM), powder X-ray diffraction (XRD), and scanning electron microscopy (SEM). The results indicate that the as-prepared products are titania glycolate submicrospheres with diameters of 230-330 nm. The average particle diameter is estimated to be about 280 nm. Ultrasonic treatment has an important influence on the morphology of the produced titania glycolates. After calcination at 450°C for 2 h, these titania glycolates were completely converted into anatase TiO2. The morphology of TiO2 particles was well reserved during the calcination process except for a reduction of 18% in the average particle size. | WANG Hong'en LI Bo YAN Zaoxuea LU Zhouguang CHENG Ruijing QIAN Donga | 2008 | Rare Metals2008，27，1： | 2 |
| 2 | Clinical case discussions-Hypopituitarism and pituitary apoplexy caused by pituitary Adenomas显示文摘A case of“Hypopituitarism and pituitary apoplex induced by pituitary Adenomas”was collected in the Third Affiliated Hospital of Inner Mongolia medical University Geriatric Department.A rare and atypical disease as it is,delayed diagnosis and treatment is easily seen among those cases.Therefore,the paper aims to investigate the difference of clinical characteristics and treatment outcome of pituitary adenomas in elder patient through the case analysis.Clinically,patients with pituitary dysfunction may have life-threatening crisis so that timely diagnosis and aggressive treatment can be effective in reducing the pituitary crisis and reducing the misdiagnosis rate. | Gaisheng Tian Qinxue Li Dan Zhao Ying Wang Ruijing Yan | 2015 | Discussion of Clinical Cases2015，2，1： | 0 |
| 3 | Sheehan’s syndrome and anterior hypopituitarism显示文摘A case of Sheehan’s syndrome and anterior hypopituitarism was collected in Geriatric department of the third clinical college of Inner Mongolia medical university.Due to atypical clinical symptoms,it is easy to be delayed in its diagnosis and treatment.The paper aims to investigate the difference of clinical characteristics and treatment outcome of anterior hypopituitarism through case analysis. | Qinxue Li Gaisheng Tian Ruijing Yan Ying Wang Yan Feng | 2015 | Discussion of Clinical Cases2015，2，1： | 0 |
| 4 | Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders显示文摘Mutations of the X-linked methyl-CpG-binding protein 2(MECP2)gene in humans are responsible for most cases of Rett syndrome(RTT),an X-linked progressive neurological disorder.While genome-wide screens in clinical trials have revealed several putative RTT-associ-ated mutations in MECP2,their causal relevance regarding the functional regulation of MeCP2 at the etiologic sites at the protein level requires more evidence.In this study,we demonstrated that MeCP2 was dynamically modified by O-linked-P-N-acetylglucosamine(O-GlcNAc)at threonine 203(T203),an etiologic site in RTT patients.Disruption of the O-GlcNAcylation of MeCP2 specifically at T203 impaired dendrite development and spine maturation in cultured hippocampal neurons,and disrupted neuronal migration,dendritic spine morphogenesis,and caused dysfunction of synaptic transmission in the developing and juvenile mouse cerebral cortex.Mechanistically,genetic disruption of O-GlcNAcylation at T203 on MeCP2 decreased the neuronal activity-induced induction of Bdnf transcription.Our study highlights the critical role of MeCP2 T203 O-GlcNAcylation in neural development and synaptic transmission potentially via brain-derived neurotrophic factor. | Juanxian Cheng Zhe Zhao Liping Chen Ying Li Ruijing Du Yan Wu Qian Zhu Ming Fan Xiaotao Duan Haitao Wu | 2022 | Neuroscience Bulletin2022，38，2： | 0 |
| 5 | Research on the changes and significance of serum RBP4 level in patients with senior coronary heart disease accompanying diabetes mellitus显示文摘Objective:To explore the significance of serum Retinol binding protein 4(RBP4)and its relationship with coronary artery lesion in patients with senior coronary heart disease accompanying T2DM by determining the level of serum RBP4 and Gensini score.Methods:30 cases of patients who were 60 years old above with coronary heart disease accompanying T2DM were selected and included in the experimental group,and 30 cases of patients of 60 years old above with coronary heart disease alone were included in the control group.Both groups of patients were given CAG examinations.In addition,Gensini score was calculated according to different degrees and parts of coronary artery lesion.It was required to record each patient’s age,gender,fasting blood glucose(FPG),triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbA1c)and other laboratory examination indexes.ELISA was used to detect the level of serum RBP4 in each group,and statistical analysis was performed to the data in each group.Results:(1)RBP4 level,GS score,FPG and LDL-C in the experimental group were all higher than those in the control group,and the difference was of statistical significance(p<.05).There was no statistically significant difference in age,gender,TC,TG and HDL-C between two groups.(2)RBP4 was positively correlated to FPG and HbA1c.(3)In patients with senior coronary heart disease accompanying diabetes mellitus,HbA1c was positively correlated to GS score,RBP4 and FPG.(4)RBP4 was a risk factor for coronary artery stenosis in patients with senior coronary heart disease accompanying diabetes mellitus.Conclusions:The level of serum RBP4 in patients with senior coronary heart disease accompanying diabetes mellitus is higher than that in patients with coronary heart disease alone,with a deeper degree of coronary artery lesion.The level of serum RBP4 is increased with the degree of lesion deepened in patients with senior coronary heart disease,suggesting that the level of serum RBP4 is expected to be an early predictor of coronary artery lesion for patients with senior coronary heart disease. | Qinxue Li Biao Ge Ruijing Yan Yinlong Bai Yan Liu | 2019 | Discussion of Clinical Cases2019，6，1： | 0 |
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