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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Development of Mining Technology and Equipment for Seafloor Massive Sulfide Deposits显示文摘Seafloor massive sulfide(SMS) deposits which consist of Au, Ag, Cu, and other metal elements, have been a target of commercial mining in recent decades. The demand for established and reliable commercial mining system for SMS deposits is increasing within the marine mining industry. The current status and progress of mining technology and equipment for SMS deposits are introduced. First, the mining technology and other recent developments of SMS deposits are comprehensively explained and analyzed.The seafloor production tools manufactured by Nautilus Minerals and similar mining tools from Japan for SMS deposits are compared and discussed in turn. Second, SMS deposit mining technology research being conducted in China is described, and a new SMS deposits mining tool is designed according to the environmental requirement. Finally, some new trends of mining technology of SMS deposits are summarized and analyzed. All of these conclusions and results have reference value and guiding significance for the research of SMS deposit mining in China. | LIU Shaojun HU Jianhua ZHANG Ruiqiang DAI Yu YANG Hengling | 2016 | Chinese Journal of Mechanical Engineering2016，29，5： | 19 |
| 3 | The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death显示文摘S-nitrosoglutathione (GSNO ) 的新陈代谢,主要生物学上活跃的氮的氧化物(没有) 种类,被进化地保存的 GSNO reductase (GSNOR ) 催化。以前的研究证明 Arabidopsis GSNOR1/HOT5 基因调整水杨酸酸由 modulating 发信号和 thermotolerance 细胞内部的 S-nitrosothiol 水平。这里,我们报导 Arabidopsis paraquat resistant2-1 (par2-1 ) 的描述显示出反房间死亡显型的异种。当由 paraquat (1,1'-dimethyl-4,4'-bipyridinium 二氯化物) 对待时,在 par2-1 的 superoxide 的生产比得上野类型的植物的,建议 PAR2 调整房间死亡的 superoxide 下游地行动。PAR2,由位置的克隆识别了,被显示与 GSNOR1/HOT5 相同。par2-1 异种在高度保存的 glycine 带一个错误感觉变化,它使变异的蛋白质变为不稳定。比作野类型, par2-1 异种有一不更高铺平,由与 4,5-diaminofluorescein diacetate 染色揭示了。与这结果一致,对待与的野类型的植物一没有施主显示抵抗到 paraquat。有趣地, GSNOR1/HOT5/PAR2 蛋白质水平除它的不变的 mRNA 水平以外,被 paraquat 导致,但是被没有施主减少。一起拿,这些结果建议 GSNOR1/HOT5/PAR2 在通过 modulating 在植物房间调整房间死亡起一个重要作用细胞内部没有水平。 | Ruiqiang Chen Shulan Sun Chun Wang Yansha Li Yan Liang Fengying An Chao Li Haili Dong Xiaohui Yang Jian Zhang Jianru Zuo | 2009 | Cell Research2009，19，12： | 14 |
| 4 | Concentrations and source identification of organochlorine pesticides (OCPs) in soils from Wolong Natural Reserve显示文摘In order to understand the distribution profile, composition characteristics and sources of OCPs, soil samples collected from Wolong Natural Reserve (WNR) in spring and autumn in 2005 were analyzed using gas chromatography coupled with electron capture detector (GC-ECD). Results showed that all OCPs concentrations were in the range of 10?2 ng/g―10?1 ng/g, representing the background level in those remote sites. Generally, their concentrations were slightly higher in spring than in autumn, which could be explained by OCPs: 1) may be released to soil from snow-melting water in spring; 2) partially evaporate into air from soil due to high temperature and intense radiation in summer and 3) can be relatively high degradation rate in summer. There were notable differences of OCPs seasonal variations between samples from alpine meadow and those from under-treeline. This phenomenon was related to physical-chemical properties of OCPs and vegetation coverage. For alpine meadow soils, levels of OCPs were increased with increasing altitudinal gradient, which was associated with enhanced scav-enging efficiency of wet precipitation. Composition characteristics of OCPs in soils were similar to those of air samples, which was distinct from those of typical contaminated soils, indicating that OCPs in WNR soils were mainly from atmospheric transport. | ZHENG XiaoYan LIU XianDe LIU WenJie JIANG GuiBin YANG RuiQiang | 2009 | Chinese Science Bulletin2009，54，5： | 11 |
| 5 | Hepatoprotective and antioxidant effects of baicalin against CCl4-induced hepatotoxicity显示文摘黄芩在东亚地区尤其是我国有广泛的栽培。采用四氯化碳(CCl4)致大鼠急性肝损伤模型研究黄芩苷的保肝作用。研究发现,黄芩苷表现出较强的体外抗氧化活性。在CCl4致大鼠急性肝损伤模型中,给予黄芩苷可有效降低CCl4引起的肝脏中谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酯酶(ALP),总胆红素(TB)和丙二醛(MDA)含量的升高,同时也提高了抗氧化防御物质超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽(GSH)的水平。切片病理观察结果也佐证了这一点。黄芩苷对CCl4致大鼠氧化应激肝损伤有保护作用,而这种保护机制可能与其清除自由基和抗氧化能力有关。 | Song Liu Xiaohui Lv Zongxi Sun Ruiqiang Su | 2015 | Journal of Chinese Pharmaceutical Sciences2015，24，8： | 8 |
| 6 | Comparisons of Two Ensemble Mean Methods in Measuring the Average Error Growth and the Predictability显示文摘In this paper, taking the Lorenz system as an example, we compare the influences of the arithmetic mean and the geometric mean on measuring the global and local average error growth. The results show that the geometric mean error (GME) has a smoother growth than the arithmetic mean error (AME) for the global average error growth, and the GME is directly related to the maximal Lyapunov exponent, but the AME is not, as already noted by Krishnamurthy in 1993. Besides these, the GME is shown to be more appropriate than the AME in measuring the mean error growth in terms of the probability distribution of errors. The physical meanings of the saturation levels of the AME and the GME are also shown to be different. However, there is no obvious difference between the local average error growth with the arithmetic mean and the geometric mean, indicating that the choices of the AME or the GME have no influence on the measure of local average predictability. | DING Ruiqiang LI Jianping | 2011 | Acta meteorologica Sinica2011，25，4： | 7 |
| 7 | Historical trends of PCBs and PBDEs as reconstructed in a lake sediment from southern Tibetan Plateau显示文摘High-altitude lake sediment can be used as a natural archive to reconstruct the history of pollutants. In this work, the temporal distribution of polychlorinated biphenyls(PCBs) and polybrominated diphenyl ethers(PBDEs) were determined using a high-resolution gas chromatography coupled with high-resolution mass spectrometer(HRGC/HRMS) in an alpine lake sediment core collected from the southern Tibetan Plateau(TP) to examine whether the expected decreasing trends due to the implementation of the international Conventions could be observed. The concentrations of PCBs and PBDEs in the sediment core were in the range of 11.8–142 pg/g dw and ND-457 pg/g dw, and their fluxes were in the range of 2.51–31.7 ng/(m^2 ·yr) and ND-43.2 ng/(m^2 ·yr), respectively. The prevalence of low-chlorinated(tri-CB) PCBs and low-brominated(tri-to tetra-) PBDEs in most sections of the sediment profiles was observed, suggesting that the light molecular weight PCBs and PBDEs have most likely reached lake sediments by long-range atmospheric transport from distant sources. Despite the restrictions on their applications, the sediment records for the concentrations and fluxes showed no corresponding decreasing trend with restrictions for PCBs, which suggested that these POPs(e.g., PCBs) were still emitted to the environment owing to the influence of primary or secondary emissions. To our knowledge, this is the first report on input history of atmospheric PCBs and PBDEs recorded in TP Lake sediment. | Ruiqiang Yang Ting Xie Pu Wang Yingming Li Qinghua Zhang Guibin Jiang | 2020 | Journal of Environmental Sciences2020，32，12： | 7 |
| 8 | Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells显示文摘 | Chong Li Song Wu Zhao Yang Xiaolong Zhang Qi Zheng Ling Lin Zexiong Niu Ruiqiang Li Zhiming Cai Lei Li | 2017 | Cell Research2017，27，4： | 7 |
| 9 | Determining the Spectrum of the Nonlinear Local Lyapunov Exponents in a Multidimensional Chaotic System显示文摘For an n-dimensional chaotic system, we extend the definition of the nonlinear local Lyapunov exponent(NLLE) from one-to n-dimensional spectra, and present a method for computing the NLLE spectrum. The method is tested on three chaotic systems with different complexity. The results indicate that the NLLE spectrum realistically characterizes the growth rates of initial error vectors along different directions from the linear to nonlinear phases of error growth. This represents an improvement over the traditional Lyapunov exponent spectrum, which only characterizes the error growth rates during the linear phase of error growth. In addition, because the NLLE spectrum can effectively separate the slowly and rapidly growing perturbations, it is shown to be more suitable for estimating the predictability of chaotic systems, as compared to the traditional Lyapunov exponent spectrum. | Ruiqiang DING Jianping LI Baosheng LI | 2017 | Advances in Atmospheric Sciences2017，34，9： | 6 |
| 10 | Characterization of a new mutant allele of the Arabidopsis Flowering Locus D (FLD) gene that controls theflowering time by repressing FLC显示文摘Flowering in higher plants is controlled by both the internal and environmental cues. In Arabidopsis, several major genetic loci have been defined as the key switches to control flowering. The Flowering Locus C (FLC) gene has been shown in the autonomous pathway to inhibit the vege-tative-to-reproductive transition. FLC appears to be re-pressed by Flowering Locus D (FLD), which encodes a com-ponent of the histone deacetylase complex. Here we report the identification and characterization of a new mutant allele fld-5. Genetic analysis indicates that fld-5 (in the Was-silewskija background) is allelic to the previously character-ized fld-3 and fld-4 (in the Colombia-0 background). Genetic and molecular analyses reveal that fld-5 carries a frame-shift mutation, resulting in a premature termination of the FLD open reading frame. The FLC expression is remarkably in-creased in fld-5, which presumably attributes to the ex-tremely delayed flowering phenotype of the mutant. | CHEN Ruiqiang ZHANG Suzhi SUN Shulan CHANG Jianhong ZUO Jianru | 2005 | Chinese Science Bulletin2005，50，23： | 6 |
| 11 | The genetics of tiger pelage color variations显示文摘 | Xiao XU Gui-Xin Dong Anne Schmidt-Kuntzel Xue-Li Zhang Yan Zhuang Run Fang Xin Sun Xue-Song Hu Tian-You Zhang Han-Dong Yang De-Lu Zhang Laurie Marker Zheng-Fan Jiang Ruiqiang Li Shu-Jin Luo | 2017 | Cell Research2017，27，7： | 5 |
| 12 | Influence of the NAO on Wintertime Surface Air Temperature over East Asia:Multidecadal Variability and Decadal Prediction显示文摘In this paper,we investigate the influence of the winter NAO on the multidecadal variability of winter East Asian surface air temperature(EASAT)and EASAT decadal prediction.The observational analysis shows that the winter EASAT and East Asian minimum SAT(EAmSAT)display strong in-phase fluctuations and a significant 60-80-year multidecadal variability,apart from a long-term warming trend.The winter EASAT experienced a decreasing trend in the last two decades,which is consistent with the occurrence of extremely cold events in East Asia winters in recent years.The winter NAO leads the detrended winter EASAT by 12-18 years with the greatest significant positive correlation at the lead time of 15 years.Further analysis shows that ENSO may affect winter EASAT interannual variability,but does not affect the robust lead relationship between the winter NAO and EASAT.We present the coupled oceanic-atmospheric bridge(COAB)mechanism of the NAO influences on winter EASAT multidecadal variability through its accumulated delayed effect of~15 years on the Atlantic Multidecadal Oscillation(AMO)and Africa-Asia multidecadal teleconnection(AAMT)pattern.An NAO-based linear model for predicting winter decadal EASAT is constructed on the principle of the COAB mechanism,with good hindcast performance.The winter EASAT for 2020-34 is predicted to keep on fluctuating downward until~2025,implying a high probability of occurrence of extremely cold events in coming winters in East Asia,followed by a sudden turn towards sharp warming.The predicted 2020/21 winter EASAT is almost the same as the 2019/20 winter. | Jianping LI Tiejun XIE Xinxin TANG Hao WANG Cheng SUN Juan FENG Fei ZHENG Ruiqiang DING | 2022 | Advances in Atmospheric Sciences2022，39，4： | 4 |
| 13 | Influence of the Preceding Austral Summer Southern Hemisphere Annular Mode on the Amplitude of ENSO Decay显示文摘There is increasing evidence of the possible role of extratropical forcing in the evolution of ENSO.The Southern Hemisphere Annular Mode(SAM) is the dominant mode of atmospheric circulation in the Southern Hemisphere extratropics.This study shows that the austral summer(December–January–February; DJF) SAM may also influence the amplitude of ENSO decay during austral autumn(March–April–May;MAM).The mechanisms associated with this SAM–ENSO relationship can be briefly summarized as follows:The SAM is positively(negatively) correlated with SST in the Southern Hemisphere middle(high) latitudes.This dipole-like SST anomaly pattern is referred to as the Southern Ocean Dipole(SOD).The DJF SOD,caused by the DJF SAM,could persist until MAM and then influence atmospheric circulation,including trade winds,over the Nio3.4 area.Anomalous trade winds and SST anomalies over the Nio3.4 area related to the DJF SAM are further developed through the Bjerkness feedback,which eventually results in a cooling(warming) over the Nio3.4 area followed by the positive(negative) DJF SAM. | Fei ZHENG Jianping LI Ruiqiang DING | 2017 | Advances in Atmospheric Sciences2017，34，11： | 3 |
| 14 | A study on surface symmetry and interfacial enhancement of SrTiO_3 by second harmonic generation显示文摘The symmetry of the surfaces of SrTiO3and slightly Nb-doped SrTiO3crystals was investigated by the optical reflected second harmonic generation technique.The good agreement between experimental and theoretical results of the second harmonic intensity dependence on the azimuth angle indicates that the SrTiO3(001)surface is with 4mm symmetry and the Nb-doped SrTiO3(111)surface with 3m symmetry.The measurements of the polarization dependent second harmonic intensity confirm that conclusion.The enhancement of the surface polarization in the structure of SrTiO3capped La0.9Sr0.1MnO3films compared with that in the La0.9Sr0.1MnO3films has been obtained. | ZHAO RuiQiang JIN KuiJuan GUO HaiZhong LU HuiBin YANG GuoZhen | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 3 |
| 15 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 16 | Flip-flops soft error rate evaluation approach considering internal single-event transient显示文摘The internal single-event transient(SET) induced upset in flip-flops is becoming significant with the increase of the operating frequency. However, the conventional soft error rate(SER) evaluation approach could only produce an approximate upset prediction result caused by the internal SET. In this paper, we propose an improved SER evaluation approach based on Monte Carlo simulation. A novel SET-based upset model is implemented in the proposed evaluation approach to accurately predict upsets caused by the internal SET. A test chip was fabricated in a commercial 65 nm bulk process to validate the accuracy of the improved SER evaluation approach. The predicted single-event upset cross-sections are consistent with the experimental data. | SONG RuiQiang CHEN ShuMing HE YiBai DU YanKang | 2015 | Science China(Information Sciences)2015，58，6： | 3 |
| 17 | Comparison of Nonlinear Local Lyapunov Vectors with Bred Vectors, Random Perturbations and Ensemble Transform Kalman Filter Strategies in a Barotropic Model显示文摘The breeding method has been widely used to generate ensemble perturbations in ensemble forecasting due to its simple concept and low computational cost. This method produces the fastest growing perturbation modes to catch the growing components in analysis errors. However, the bred vectors(BVs) are evolved on the same dynamical flow, which may increase the dependence of perturbations. In contrast, the nonlinear local Lyapunov vector(NLLV) scheme generates flow-dependent perturbations as in the breeding method, but regularly conducts the Gram–Schmidt reorthonormalization processes on the perturbations. The resulting NLLVs span the fast-growing perturbation subspace efficiently, and thus may grasp more components in analysis errors than the BVs.In this paper, the NLLVs are employed to generate initial ensemble perturbations in a barotropic quasi-geostrophic model.The performances of the ensemble forecasts of the NLLV method are systematically compared to those of the random perturbation(RP) technique, and the BV method, as well as its improved version—the ensemble transform Kalman filter(ETKF)method. The results demonstrate that the RP technique has the worst performance in ensemble forecasts, which indicates the importance of a flow-dependent initialization scheme. The ensemble perturbation subspaces of the NLLV and ETKF methods are preliminarily shown to catch similar components of analysis errors, which exceed that of the BVs. However, the NLLV scheme demonstrates slightly higher ensemble forecast skill than the ETKF scheme. In addition, the NLLV scheme involves a significantly simpler algorithm and less computation time than the ETKF method, and both demonstrate better ensemble forecast skill than the BV scheme. | Jie FENG Ruiqiang DING Jianping LI Deqiang LIU | 2016 | Advances in Atmospheric Sciences2016，33，9： | 3 |
| 18 | Chemical looping gasification of sewage sludge using copper slag modified by NiO as an oxygen carrier显示文摘Chemical looping gasification(CLG) provides a novel approach to dispose the sewage sludge.In order to improve the reactivity of the calcined copper slag,NiO modification is considered as one of the good solutions.The copper slag calcined at 1100℃ doped with 20 wt% NiO(Ni20-CS) was used as an oxygen carrier(OC) in sludge CLG in the work.The modification of NiO can evidently enhance the reactivity of copper slag to promote the sludge conversion,especially for sludge char conversion.The carbon conversion and valid gas yield(V_(g)) increase from 67.02% and 0.23 m^(3)·kg^(-1) using the original OC to 78.34% and 0.29 m^(3)·kg^(-1) using the Ni20-CS OC, respectively.The increase of equivalent coefficient(Ω) facilitates the sludge conversion and a suitable Ω value is determined at 0.47 to obtain the highest valid gas yield(0.29 m^(3)·kg^(-1)).A suitable steam content is assigned at 27.22% to obtain the maximum carbon conversion of 87.09%,where an acceptable LHV of 12.63 MJ·m^(-3) and Vg of 0.39 m^(3)·kg^(-1)are obtained.Although the reactivity of Ni20-CS OC gradually decreases with the increase in cycle numbers because of the generation of NiFe_(2) O_(4-δ) species,the deposition of sludge ash containing many metallic elements is beneficial to the sludge conversion.As a result,the carbon conversion shows a slight uptrend with the increase of cycle numbers in sludge CLG.It indicates that the Ni20-CS sample is a good OC for sludge CLG. | Nanhang Dong Ruiqiang Huo Ming Liu Lisheng Deng Zhengbing Deng Guozhang Chang Zhen Huang Hongyu Huang | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 2 |
| 19 | Analyzing and mitigating the internal single-event transient in radiation hardened flip-flops at circuit-level显示文摘Internal SET has become a great concern in normal radiation-hardened flip-flops with increases in frequency.We investigate the internal SET problem in the traditional hardened flip-flops in this article.We also propose a novel structure to eliminate the internal SET problem.Three-dimensional technology computer-aided design(TCAD)was adopted to verify the hardened performance of this proposed novel structure.Besides,the power and setup time were compared with the traditional hardened flip-flops. | LIANG Bin SONG RuiQiang | 2014 | Science China(Technological Sciences)2014，57，9： | 2 |
| 20 | Determination of the Backward Predictability Limit and Its Relationship with the Forward Predictability Limit显示文摘In this work, two types of predictability are proposed—forward and backward predictability—and then applied in the nonlinear local Lyapunov exponent approach to the Lorenz63 and Lorenz96 models to quantitatively estimate the local forward and backward predictability limits of states in phase space. The forward predictability mainly focuses on the forward evolution of initial errors superposed on the initial state over time, while the backward predictability is mainly concerned with when the given state can be predicted before this state happens. From the results, there is a negative correlation between the local forward and backward predictability limits. That is, the forward predictability limits are higher when the backward predictability limits are lower, and vice versa. We also find that the sum of forward and backward predictability limits of each state tends to fluctuate around the average value of sums of the forward and backward predictability limits of sufficient states.Furthermore, the average value is constant when the states are sufficient. For different chaotic systems, the average value is dependent on the chaotic systems and more complex chaotic systems get a lower average value. For a single chaotic system,the average value depends on the magnitude of initial perturbations. The average values decrease as the magnitudes of initial perturbations increase. | Xuan LI Ruiqiang DING Jianping LI | 2019 | Advances in Atmospheric Sciences2019，36，6： | 1 |
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