3篇
您的检索式：作者名="Yuangang Su"
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| 1 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 2 | Rapid microwave-assisted transesterification for the preparation of fatty acid methyl esters from the oil of yellow horn (Xanthoceras sorbifolia Bunge.)显示文摘 | Yuangang Zu Su Zhang Yujie Fu Wei Liu Zhiguo Liu Meng Luo Thomas Efferth | 2009 | European Food Research and Technology2009，，1： | 1 |
| 3 | Motional n-phonon bundle states of a trapped atom with clock transitions显示文摘Quantum manipulation of individual phonons could offer new resources for studying fundamental physics and creating an innovative platform in quantum information science. Here,we propose to generate quantum states of strongly correlated phonon bundles associated with the motion of a trapped atom. Our scheme operates in the atom–phonon resonance regime where the energy spectrum exhibits strong anharmonicity such that energy eigenstates with different phonon numbers can be well-resolved in the parameter space. Compared to earlier schemes operating in the far dispersive regime,the bundle states generated here contain a large steady-state phonon number. Therefore,the proposed system can be used as a high-quality multiphonon source. Our results open up the possibility of using long-lived motional phonons as quantum resources,which could provide a broad physics community for applications in quantum metrology. | YUANGANG DENG TAO SHI SU YI | 2021 | Photonics Research2021，9，7： | 0 |
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