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| 1 | Current adjuvant treatment modalities for gastric cancer:From history to the future显示文摘The discrepancy between the surgical technique and the type of adjuvant chemotherapy used in clinical trials and patient outcomes in terms of overall survival rates has led to the generation of different adjuvant treatment protocols in distinct parts of the world.The adjuvant treatment recommendation is generally chemoradiotherapy in the United States,perioperative chemotherapy in the United Kingdom and parts of Europe,and chemotherapy in Asia.These options mainly rely on the United States Intergroup-0116,United Kingdom British Medical Research Council Adjuvant Gastric Infusional Chemotherapy,and the Asian Adjuvant Chemotherapy Trial of S-1 for Gastric Cancer and Capecitabine and Oxaliplatin Adjuvant Study in Stomach Cancer trials.However,the benefits were evident for only certain patients,which were not very homogeneous regarding the type of surgery,chemotherapy regimens,and stage of disease.Whether the dissimilarities in survival are attributable to surgical technique or intrinsic biological differences is a subject of debate.Regardless of the extent of surgery,multimodal therapy may offer modest survival advantage at least for diseases with lymph node involvement.Moreover,in the era of individualized treatment for most of the other cancer types,identification of special subgroups comprising those who will derive more or no benefit from adjuvant therapy merits further investigation.The aim of this review is to reveal the historical evolution and future reflections of adjuvant treatment modalities for resected gastric cancer patients. | Leyla Kilic Cetin Ordu Ibrahim Yildiz Fatma Sen Serkan Keskin Rumeysa Ciftci Kezban Nur Pilanci | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 9 |
| 2 | Clinical and Prognostic Significance of Coagulation Assays in Advanced Epithelial Ovarian Cancer显示文摘 | Faruk Tas Leyla Kilic Elif Bilgin Serkan Keskin Fatma Sen Rumeysa Ciftci Ibrahim Yildiz Vildan Yasasever | 2013 | International Journal of Gynecological Cancer2013，，2： | 1 |
| 3 | QT interval dispersion in the patients with central serous chorioretinopathy显示文摘AIM: To evaluate QT dispersion(QTD) in patients with central serous chorioretinopathy(CSC).METHODS: This clinical, comperative, case-control study included 30 patients with CSC at acute phase(Group 1) and 30 age- and sex-matched healthy subjects(Group 2, the control group). From all subjects, a 12-lead surface electrocardiography was obtained. The heart rate(HR), QT maximum(QT max), QT minimum(QT min), QT corrected(QT c), QTD and T mean were manually measured and analyzed. Student's t-test and Pearson's method of correlation were used for statistical analysis.· RESULTS: The patient and control groups were matched for age, smoking status(rate and duration) and gender. There were no significant differences with regard to these among the groups(P >0.05). The participants included 19 men(63.3%) and 11 women(36.7%) in Group1, 20 men(66.7%) and 10 women(33.3%) in Group 2.QT max, QTD and QT c were significantly higher than those of healthy controls(P <0.001 for QT max, P =0.01 for QTD and P =0.001 for QT c). QT min, T mean and HR did not differ significantly between the study groups(P =0.28 for QT min,P =0.56 for T mean and P >0.05 for HR). No significant correlation was found between duration of the disorder and QTD values(r =0.13, P >0.05).CONCLUSION: These findings suggest that CSC may be associated with an increase in QTD and that the patients might be at risk for ventricular arrhythmia. | Necati Dagli Burak Turgut Rumeysa Tanyildizi Sabiha Kobat Mehmet Ali Kobat Orhan Dogdu | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 0 |
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