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| 1 | Exposure to dibutyl phthalate impairs lipid metabolism and causes inflammation via disturbing microbiota-related gut-liver axis显示文摘Dibutyl phthalate(DBP),a kind of typical environm ental pollutant,is widely used as plasticizers,and its neurotoxicity and developm ental toxicity have been found in recent years.However,whether oral DBP exposure w ill affect the homeostasis of gut m icrobiota and its adverse response in liver of m am m alians remain unclear.In the present study,10-week experimental cycles of vehicle or DBP(0.1 and 1mg/kg)were given to 6-week-old C57BL/6J mice by oral gavage.Our results revealed that the body weight of mice was increased after exposure to both low and high doses of DBP.The serum levels of hepatic triglyceride and total cholesterol were significantly increased in response to both doses of DBP.In addition,some pivotal genes related to lipogenesis were also increased in liver at the mRNA level.Evaluation of gut m icrobiota by 16S rRNA sequencing technology showed that 0.1 mg/kg DBP exposure significantly affected gut microbiota at the phylum and genus levels.Moreover,DBP exposure decreased mucus secretion and caused inflam m ation in the gut,leading to the im pairm ent of intestinal barrier function.Exposure to OBP inhibited the expression of peroxisome proliferator-activated receptor-y and activated the expression of nuclear factor kappa B.In addition,DBP exposure increased the level of lipopolysaccharide in serum,and increased the expression of toll-like receptor 4 and the levels of inflam m atory cytokines,such as interleukin(IL)-1β,IL-6,and tumor necrosis factor alpha,in the liver.These results indicated that exposure to DBP disturbed the homeostasis of gut m icrobiota,induced hepatic lipid m etabolism disorder,and caused liver inflam mation in mice via the related gut-liver axis signaling pathways. | Ze Xiong Yuyao Zeng Jiafeng Zhou Ruonan Shu Xiaoxian Xie Zhengwei Fu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 2 |
| 2 | Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial显示文摘We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March 2016.They were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or placebo.Their clinical and immunological parameters were monitored during the 96-week follow-up study.We found that hUC-MSC treatment was safe and well-tolerated.Compared with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control group.Kaplan-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three groups.In summary,hUC-MSC treatment is safe.However,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study. | Lifeng Wang Zheng Zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang Mi Zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou Ming Shi Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 3 | Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice显示文摘Circadian rhythms are present in all organisms.The endogenous circadian clock is an autonomous temporal system that generates a rhythm of approximately 24 h even in the absence of environmental signals.The'core'genes in the circadian clock system of mammals consist of Clock and Bmall,which generate activators,along with Cryl,Cry2,Per1 and Per2,which generate repressors. | Xiaoxian Xie Haoshen Xu Ruonan Shu Lei Sun Mengya Zhang Qinglian Hu Kai Zhu Zezhi Li Fengchun Wu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
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