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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | China's treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world显示文摘Fulminant myocarditis is characterized by acute and severe inflammation with injury of myocardium globally. It has a fulminant course and high in-hospital mortality rate of up to50%-70%. It onsets rapidly after viral infection and progresses to hypotension. | Jing Zhang Weijian Hang Rutai Hui Qiong Zhao Shashank S.Desai | 2019 | Science China(Life Sciences)2019，62，2： | 8 |
| 3 | Telomeres,cardiovascular aging,and potential intervention for cellular senescence显示文摘A consistent association has been observed between leukocyte telomere length(LTL)and atherosclerosis,but the mechanisms underlying these associations are still not well understood.Premature biology aging was evident in atherosclerotic plaques,characterized by reduced cell proliferation,irreversible growth arrest and apoptosis,and telomere attrition.As atherosclerosis is a state of chronic low-grade inflammation and increased oxidative stress,shortened LTL in patients with atherosclerosis might stem from the two sources,one is an accelerated rate in hematopoietic stem cells(HSCs)replication to replace leukocytes consumed in the inflammatory process,and another is the increase in the loss of telomere repeats per replication.Thus,diminished HSC reserves at birth and age-dependent telomere attrition afterward are mirrored in shortened LTL during the adulthood.In addition,the inter-individual variation of LTL in the general population can be partly explained by genetic factors regulating telomere maintenance and the rate of HSCs replication.Atherosclerosis is an aging-related disease,and practically all humans develop atherosclerosis if they live long enough.Here we overview the potential roles of LTL dynamics in the imbalance between injurious oxidative stress/inflammation and endothelial repair during the pathogenesis of age-related atherosclerosis,and discuss the possibility that preventing accelerated cellular senescence is a potential target in prevention of atherosclerosis. | ZHANG WeiLi HUI RuTai YANG ShuJun | 2014 | Science China(Life Sciences)2014，57，8： | 5 |
| 4 | Spatial heterogeneity of lake eutrophication caused by physiogeographic conditions:An analysis of 143 lakes in China显示文摘In order to identify the effect of geographic characteristics on the variations of nutrient concentrations and the utilization efficiency of nutrients by phytoplankton, data from 143 lakes, from 2008 to 2010, including three very different types of topography, i.e., the first topography ladder(FTL), second topography ladder(STL), and third topography ladder(TTL), were statistically analyzed. Lakes in the FTL and STL, located at high elevation(above1000 m) and low longitudes(lower than 105° E), were sporadically oligotrophic, whereas lakes in the TTL were almost all mesotrophic and eutrophic. The trophic level index(TLI)became higher with the rise of longitude. Two turning points(5 and 15°C) on the curve of TLI as function of the average annual temperature(AAT) corresponded with the AAT in different lake regions in the STL and TTL. Because the responses of TLI to AAT differ significantly, there were variations of nutrient and algal biomass concentrations in different lake regions in the same type of topography ladder. According to the differences in utilization efficiency of total nitrogen or total phosphorus by phytoplankton, China could be partitioned into six lake regions. Scientific nutrient criteria for each lake region shall be established considering these differences in China. | Jingtao Ding Jinling Cao Qigong Xu Beidou Xi Jing Su Rutai Gao Shouliang Huo Hongliang Liu | 2015 | Journal of Environmental Sciences2015，27，4： | 5 |
| 5 | Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: A meta-analysis显示文摘 | Wenlong Li Jing Xu Xiaojian Wang Jingzhou Chen Channa Zhang Kai Sun Rutai Hui | 2009 | Atherosclerosis2009，，2： | 1 |
| 6 | Hyperhomocysteinemia decreases circulating high density lipoprtein by inhibiting apolipoprotein A-I protein synthesis and enhancing HDL cholesterol clearance 显示文摘 | Dan L Hongmei T Rutai H et aI | 2006 | Circ Res2006，99，6： | 1 |
| 7 | MiR‐451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC 1显示文摘 | Lei Song Ming Su Shuiyun Wang Yubao Zou Xiaojian Wang Yilu Wang Hongli Cui Peng Zhao Rutai Hui Jizheng Wang | 2014 | J. Cell. Mol. Med2014，，： | 1 |
| 8 | Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population显示文摘 | Yanhui Lu Yanfen Zhao Guozhang Liu Xiaoling Wang Zhihong Liu Baiping Chen Rutai Hui | 2002 | Thrombosis Research2002，，1： | 1 |
| 9 | Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China显示文摘 | Zhaohui Li Li Sun Hongye Zhang Yuhua Liao Daowen Wang Bingrang Zhao Zhiming Zhu Jizong Zhao Aiqun Ma Yu Han Yibo Wang Yi Shi Jue Ye Rutai Hui | 2003 | Stroke: Journal of the American Heart Association2003，，9： | 1 |
| 10 | Lack of association between the G protein β3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study显示文摘 | Xiaohong Huang Zhenyu Ju Yan Song Hongye Zhang Kai Sun Hongyan Lu Zhiwei Yang Pedro A. Jose Gang Zhou Meng Wang Weifeng Wang Shixian Feng Rutai Hui | 2003 | Journal of Molecular Medicine2003，，11： | 1 |
| 11 | The devolopent of fibrocartilaeg in rat interverrebral disc 显示文摘 | RUTAI A BENJAMIN M RALPHS J R | 1995 | Orthop Res1995，192，： | 1 |
| 12 | Factors Influencing Prognosis in Patients With Marfan Syndrome After Aortic Surgery显示文摘 | Linggen Gao Xianliang Zhou Lin Zhang Dan Wen Qian Chang Yongbo Wu Lizhong Sun Rutai Hui | 2011 | Journal of Cardiothoracic and Vascular Anesthesia2011，，4： | 1 |
| 13 | A retrospective clinical study of transaortic extended septal myectomy for obstructive hypertrophic cardiomyopathy in China显示文摘 | Shuiyun Wang Mingyao Luo Hongtao Sun Yunhu Song Chaohua Yin Liqing Wang Rutai Hui Shengshou Hu | 2013 | European Journal of Cardio-Thoracic Surgery2013，，3： | 1 |
| 14 | Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population显示文摘 | Yanhui Lu Yanfen Zhao Guozhang Liu Xiaoling Wang Zhihong Liu Baiping Chen Rutai Hui | 2002 | Thrombosis Research2002，，1： | 1 |
| 15 | Hyperhomoeysteinemia decreases circulating high-density lipoprtein by inhibiting apolipoprotein A--I protein synthesis and enhancing HDL cholesterol clearance 显示文摘 | Dan L Hongmei T Rutai H | 2006 | CircRes2006，99，： | 1 |
| 16 | Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China显示文摘 | Zhaohui Li Li Sun Hongye Zhang Yuhua Liao Daowen Wang Bingrang Zhao Zhiming Zhu Jizong Zhao Aiqun Ma Yu Han Yibo Wang Yi Shi Jue Ye Rutai Hui | 2003 | Stroke: Journal of the American Heart Association2003，，9： | 1 |
| 17 | Cystatin C, Associated With Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese显示文摘 | Li Ni Jiagao Lü Ling Bo Hou Jiang Tao Yan Qiao Fan Rutai Hui Katherine Cianflone Wei Wang Dao Wen Wang | 2007 | Stroke2007，，： | 1 |
| 18 | Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies显示文摘 | Lin Meng Dongmei Chen Yang Yang Yang Zheng Rutai Hui | 2012 | Journal of Hypertension2012，，5： | 1 |
| 19 | Cystatin C, Associated With Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese显示文摘 | Li Ni Jiagao Lü Ling Bo Hou Jiang Tao Yan Qiao Fan Rutai Hui Katherine Cianflone Wei Wang Dao Wen Wang | 2007 | Stroke2007，，12： | 1 |
| 20 | Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis显示文摘 | Zhang Weili Sun Kai Yang Ying Zhang Hongye Hu Frank B Hui Rutai | 2009 | Clinical Chemistry2009，，： | 1 |
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