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| 1 | Constructing highly dispersed 0D Co3S4 quantum dots/2D g-C3N4 nanosheets nanocomposites for excellent photocatalytic performance显示文摘The development of noble-metal-free catalysts with high efficiency photocatalytic properties is critical to the heterogeneous catalysis. Herein, zero-dimensional(0 D) metal sulfide quantum dots/two-dimensional(2 D) g-C3N4 nanosheets(Co3S4/CNNS) nanocomposites are synthesized by a two-step method, including the ways of in-situ deposition and water bath. The highly dispersed Co3S4 quantum dots(particle size is2–4 nm) are evenly and tightly fixed on CNNS, which can be used as co-catalyst to effectively replace noble metals to improve the photocatalytic properties of CNNS. Co3S4/CNNS-900 has the apparent quantum efficiency, which is up to 7.85% at 400 nm. At the same time, the H2 evolution rate of Co3S4/CNNS-900 is 20,536.4 lmol gà1 hà1, which is 555 times than CNNS. The excellent photocatalytic performance is due to the highly dispersed Co3S4 quantum dots on 2 D CNNS, which facilitate the formation of more active sites, Co3S4/CNNS promotes the separation and migration of photogenerated carriers, shortens the migration distance of photogenerated carriers, and eventually leads to an increase of the photocatalytic performance. | Hongcen Yang Jiangmei Yin Ruya Cao Pengxiao Sun Shouwei Zhang Xijin Xu | 2019 | Science Bulletin2019，64，20： | 7 |
| 2 | Degradation of amyloid β-peptides catalyzed by nattokinase in vivo and in vitro显示文摘Amyloid-β 1-42(Aβ42)plays a pivotal role in Alzheimer disease(AD)pathogenesis. Peripheral clearance of Aβ42 largely affects its level in the brain and affects AD progression. Although nattokinase(NK)degrades Aβ40, the details of NK's capture of various Aβ species and reduction of plasma Aβ42/Aβ40 are uncharacterized. In this study, the Aβ42/Aβ40-degrading ability of NK was investigated using five Aβs and AD model mice. The C-terminal region of Aβ42/Aβ40(Gly29 to Val40)was primarily required for NK capture, and the integrated conformation in Aβ42/Aβ40 aggregates was a more efficient target for NK catalysis. Further, suspended Aβ42/Aβ40 oligomers were more easily captured by NK than suspended Aβ42/Aβ40 fibrils, while deposited Aβ42/Aβ40 fibrils recruited more NK than deposited Aβ42/Aβ40 oligomers. Although most NK was likely lost during NK uptake and/or entry into the blood, a small fraction of NK showed good plasma Aβ42/Aβ40-degrading efficacy after entering the blood due to NK's stability in the plasma of AD mice for at least 9 days. It was concluded that oral administration of NK is a feasible approach for peripheral Aβ42/Aβ40 clearance. This implies that NK might serve as an anti-Aβ42 agent for the treatment of Aβ42/Aβ40-related diseases such as AD. | Aixin Ni He Li Ruya Wang Rentong Sun Yingjiu Zhang | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 3 | Single-cell RNA sequencing-based immunological feature analysis of a COVID-19 patient with recurrent positive SARS-CoV-2 RNA显示文摘To the Editor:Since the outbreak in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected>2.4 billion people worldwide,resulting in>4.9 million deaths.To understand the pathogenesis of SARS-CoV-2 infection,single-cell RNA-sequencing(scRNA-seq)profiles of peripheral blood mononuclear cells(PBMCs)have been constructed in coronavirus disease-2019(COVID-19)patients at different disease stages. | Bin Su Ruya Sun Lili Zhang Jiaying Zhang Xia Feng Zhenhuan Cao Wei Hou Xianghua Guo Qing Ge Qinghua Cui Yuan Zhou Yingmin Ma Ronghua Jin Yingmei Feng | 2022 | Chinese Medical Journal2022，，8： | 0 |
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