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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions显示文摘BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques fail.The use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic strictures.AIM To describe the technique,efficacy,and safety of PTABs for EUS-guided PD interventions.METHODS Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database.PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire.The primary outcome was technical success.Secondary outcomes included incidence of adverse events(AEs)and need for early reintervention.RESULTS A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)cases.Overall AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural pain.No patients required early re-intervention.CONCLUSION EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. | Jad P AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，8： | 2 |
| 3 | ADAM-17 expmssion in breast cancer correlates with variables of tumor progression显示文摘 | MCGOWAN P M RYAN B M HILL A D | 2007 | Clin Cancer Res2007，13，8： | 1 |
| 4 | Limitation of lowland riverine bacterioplankton by dissolved organic carbon and inorgan- ic nutrients显示文摘 | Douglas P Simon M Ryan M D | 2010 | Hydrobiologia2010，652，： | 1 |
| 5 | Fabrication methods of porous metals for use in orthopaedic applications显示文摘 | Ryan G Pandit A Apatsidis D P | 2006 | Biomaterials2006，27，13： | 1 |
| 6 | Engineering high lev el aluminium tolerance in barley with the ALMT1 gene显示文摘 | Delhaize E Ryan P R Hebb D M | 2004 | Proceedings of the National Academy of Sciences of the U nited Stales of America2004，101，15： | 1 |
| 7 | PAST: Paleontological Statistics Software Package for Education and Data Analysis显示文摘 | ф Hammer D A T Harper P D Ryan | 2001 | Palaeontologia Electronica2001，4，1： | 1 |
| 8 | The roles of organic anion permeases in aluminium resistance andmineral nutrition 显示文摘 | Delhaize E Gruber B D Ryan P R | 2007 | FEBS Letters2007，581，： | 1 |
| 9 | Build-a-case:a brand new continuing medical education technique that is peculiarly familiar显示文摘 | Ryan D P Marlow B | 2004 | J Contin Educ Health Prof2004，24，2： | 1 |
| 10 | Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro显示文摘 | Ryan I P Schriock E D Taylor R N | 1994 | J Clin Endoerinol Metab1994，78，3： | 1 |
| 11 | Co translational,in- traribosomal cleavage of polypeptides by the foot-and mouth dis ease virus 2A peptide显示文摘 | De Felipe P Hughes L E Ryan M D | 2003 | J Biol Chem2003，278，11： | 1 |
| 12 | Phytoestro- gen interaction with estrogen receptors in human breast cancer cells 显示文摘 | Martin P M Horwitz K 13 Ryan D S | 1978 | Endocrinology1978，1035，： | 1 |
| 13 | Plant regeneration via organo2 genesis and embryogenesis in the maize inbred line B73显示文摘 | Lowe K Taylor D B Ryan P | 1985 | Plant Science1985，41，2： | 1 |
| 14 | Phase Ⅱ study of recombinant human endostatin in patients with advanced neuroendocrine tumors显示文摘 | KULKE M H BERGSLAND E K RYAN D P | 2006 | J Clin Oncol2006，24，22： | 1 |
| 15 | Linking the physiology and ecology of Cochlodinium to better understand harmful algal bloom events: A comparative approach 显示文摘 | KUDELA R M RYAN J P BLAKELY M D | 2008 | Harm- ful Algae2008，7，3： | 1 |
| 16 | Temperature prediction in stratified reservoirs 显示文摘 | Huber W C Harleman D R F Ryan P J | 1972 | Journal of the Hydraulics Division1972，98，4： | 1 |
| 17 | Recent oceurrenee of Cylindrospermopsis raciborskii in Waikato lakes of New Zealand显示文摘 | Ryan E F Hamilton D P Barnes G 2003 | 2003 | New Zealand Journal of Marine and Freshwater Research2003，37，： | 1 |
| 18 | Prognostic significance of angiographically documented left ventricular aneurysm from the Coronary Artery Surgery Study (CASS) 显示文摘 | Faxon D P Ryan T J Davis K B | 1982 | Am J Cardiol1982，50，1： | 1 |
| 19 | Urinary levels of insecticide metabolites and DNA damage in human sperm显示文摘 | MEEKER J D SINGH N P RYAN L | 2004 | Human Reproduction2004，19，11： | 1 |
| 20 | Lithium abundance and isotope systematics of forearc serpentinites, Conical Sea- mount, Mariana forearc: Insights into the mechanics of slab- mantle exchange during subduction显示文摘 | Benton L D Ryan J G Savov I P | 2004 | Geochemistry Geo- physics Geosystems2004，5，8： | 1 |
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