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| 1 | Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer显示文摘AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal cancer.METHODS We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN metastasis.The patients had distant metastasis such as liver,lung,peritoneum,and paraaortic LN.Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan.All patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 patients.We evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME groups.RESULTS For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic factor.Regarding cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis. | Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano Masato Nakano Masayuki Nagahashi Jun Sakata Takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai | 2017 | World Journal of Clinical Oncology2017，8，5： | 4 |
| 2 | Health Emergency and Disaster Risk Management (Health-EDRM):Developing the Research Field within the Sendai Framework Paradigm显示文摘The intersection of health and disaster risk reduction(DRR) has emerged in recent years as a field of critical inquiry.Health is recognized as an outcome and a goal of DRR,and the integration of both fields is essential to ensure the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.Health Emergency and Disaster Risk Management(Health-EDRM) has emerged as an umbrella field that encompasses emergency and disaster medicine,DRR,humanitarian response,community health resilience,and health systems resilience.In September 2016,an international group of experts met in Hong Kong to assess the current status and potential of the Health-EDRM research field,a research area that these scholars characterized as underdeveloped and fragmented.Key challenges identified include research overlap,lack ofstrategic research agenda,absence of consensus regarding terminology,and limited coordination between stakeholders.The Sendai Framework provides a useful paradigm within which to shape the research field's strategic development.The WHO Thematic Platform for Health-EDRM Research Group was established to coordinate activities,promote information-sharing,develop partnerships,and provide technical advice to strengthen the Health-EDRM research field.This group will promote the generation of robust and scientific health research to support the meaningful implementation of the Sendai Framework. | Sharon Tsoon Ting Lo Emily Ying Yang Chan Gloria Kwong Wai Chan Virginia Murray Jonathan Abrahams Ali Ardalan Ryoma Kayano Johnny Chung Wai Yau | 2017 | International Journal of Disaster Risk Science2017，8，2： | 3 |
| 3 | Expressing of the OsPll geBe, cloned from rice roots using cDNA microarray, rapidly responds to phosphorus 显示文摘 | Wasaki J Ryoma Y T Shinano T Kai M Osaki M | 2003 | New Phytologist2003，158，2： | 1 |
| 4 | Endoscopic Transaqueductal Placement of a Single-Catheter Cyst-Ventrieuloperitonea| Shunt in a Neonate With Dandy-Walker Malformation-Associated Hydrocephalus显示文摘 | Ryoma Moringaki Kyong-Hon POOH | 2011 | Neurol Med Chit (Tokyo)2011，51，1： | 1 |
| 5 | New Techniques for Exposure of Posterior Cervical Spine Through Intermuscular Planes and Their Surgical Application显示文摘 | Tateru Shiraishi Masahiro Kato Yoshiyuki Yato Seiji Ueda Ryoma Aoyama Jun-ichi Yamane Kazuya Kitamura | 2012 | Spine2012，，5： | 1 |
| 6 | Daunorubicin can eliminate iPS-derived cancer stem cells via ICAD/CAD-independent DNA fragmentation显示文摘Aim:To identify a drug that can effectively eliminate these cancer stem cells(CSCs)and determine its mode of action.Methods:CSCs were obtained from mouse induced pluripotent stem cells(miPSCs)using cancer cell-conditioned media.Drug screening was performed on these cells or after transplantation into mice.Apoptosis was analyzed by flow cytometry and western blotting.Results:Drug screening studies showed that daunorubicin,a topoisomerase II inhibitor,is specifically cytotoxic to miPS-CSCs.Daunorubicin-induced apoptosis was found to be associated with p53 accumulation,activation of the caspase cascade,and oligonucleosomal DNA fragmentation.Treatment with the caspase inhibitor abolished daunorubicin-induced DNA fragmentation and was therefore considered to act downstream of caspase activation.This was also suppressed by treatment with a Ca2+-specific chelator,which suggested that CAD endonuclease does not contribute.Moreover,no obvious ICAD reduction/degradation was detected.Conclusion:Daunorubicin effectively eliminated CSCs,which are dependent on the p53/caspase signaling cascade.The current findings provided the basis for further studies on CSC-targeted drugs for the development of cancer treatment strategies. | Akimasa Seno Akifumi Mizutani Kazuki Aizawa Ryoma Onoue Junko Masuda Naotaka Ochi Saki Taniguchi Tatsuyuki Sota Yuki Hiramoto Taisuke Michiue Neha Nair Masaharu Seno | 2019 | Cancer Drug Resistance2019，2，2： | 1 |
| 7 | 王秀竹 电影也是一种哲学显示文摘在民国剧《偏偏喜欢你》中,王秀竹白哲皙的皮肤、乌黑的马尾,搭配粉色的护士服,让护士装扮显得清新可人。尤其在一片军校制服迷彩里,显得尤为妩媚和柔美。她藉此获得第二届横店影视文荣奖未来之星奖。2015年,出演都市青春偶像励志剧《花火》。2016年,主演玄幻剧《玄门大师》。2017年,出演古装剧《三生三世十里桃花》中痴情的东海公主缪清。 | 刘玉方 郭嘉 ryoma | 2018 | 时尚北京2018，0，7： | 1 |
| 8 | Biological effect of OK-432 (picibanil) and possible application to dendritic cell therapy 显示文摘 | Ryoma Y Moriya Y Okamoto M | 2004 | Anticancer Res2004，24，5： | 1 |
| 9 | Biological Effect of OK-432(Picibanil)and Possible Application to Dendritic Cell Therapy显示文摘 | Yoshiki Ryoma Yoichiro Moriya Masato Okamoto | 2004 | Anticancer Res2004，8，24： | 1 |
| 10 | Health Emergency and Disaster Risk Management: Five Years into Implementation of the Sendai Framework显示文摘The Sendai Framework for Disaster Risk Reduction 2015–2030 recognizes health at the heart of disaster risk management(DRM)at the global policy level.Five years on,it has catalyzed the rapid development of the field of Health Emergency and Disaster Risk Management(Health EDRM)by providing a mandate for building partnerships as well as enhancing scientific research.Key milestones achieved include publication of the World Health Organization’s Health EDRM Framework,development of the WHO Thematic Platform for Health EDRM and the WHO Health EDRM Research Network,and further application of health information principles to DRM.Furthermore,health actors at all levels have continued to engage in the Sendai Framework processes and have had a key role in its implementation and proposed monitoring.There have been significant gains made through the partnership of health and DRM,but the relationship has not been without its challenges.Many national,regional,and global initiatives continue to operate with a lack of consistency and of linkages to respond to the Sendai Framework’s call for embedding health resilience in DRM,and conversely,embedding DRM in health resilience.Overcoming this hurdle is important,and doing so will be a key marker of success of the next 10 years of partnership under the Sendai Framework. | Natalie Wright Lucy Fagan Jostacio MLapitan Ryoma Kayano Jonathan Abrahams Qudsia Huda Virginia Murray | 2020 | International Journal of Disaster Risk Science2020，11，2： | 1 |
| 11 | Regulating the onset of mitosis显示文摘 | Ryoma Ohi Kathleen L Gould | 1999 | Current Opinion in Cell Biology1999，，： | 1 |
| 12 | Molecular cloning of canine nm23 cDNAs and their expression innormal and tumor tissues 显示文摘 | Masashi T Ryoma U Kenjiro F | 2005 | Vet Med Sci2005，67，8： | 1 |
| 13 | Bilateral pallidal deep brain stimulation in primary Meige syndrome 显示文摘 | Wataru S Ryoma M Yoshifumi M | 2011 | Parkiusonism Relat Disord2011，17，： | 1 |
| 14 | Laser-Assisted Combustion of Solid Propellant at Low Pressures 显示文摘 | Akira Kakami Ryoma Hiyaraizu Kiyotaka Sbuzenji | 2008 | Journal of Propulsion and Power2008，24，6： | 1 |
| 15 | 斯瓦卡拉轻薄温暖的天然之选显示文摘近日在位于北京751的王玉涛工作室展厅,哥本哈根皮草联同国际知名设计师Jorgen Simonsen与中国著名设计师王玉涛先生,共同举办了斯瓦卡拉111周年设计巡展北京站的媒体答谢活动。百年斯瓦卡拉,传承最轻薄温暖的秋冬传奇SWAKARA-斯瓦卡拉素有“非洲黑钻石”的美誉,自1907年在非洲草原被培育及发展至今积累了百余年纳米比亚人民的心血及智慧。斯瓦卡拉拥有顺滑流畅的图案,丝绸质感的光泽,以及平整轻薄的外型。这种产自于纳米比亚的皮草体现的卓越品质,缔造了全球最令人心动的轻型保暖材质。 | Ryoma | 2019 | 时尚北京2019，0，1： | 1 |
| 16 | Biological effect of OK-432 (picibanil) and possible application to dendritic cell therapy显示文摘 | Ryoma Y Moriya Y Okamoto M | 2004 | Anticancer Res2004，24，5： | 1 |
| 17 | 秋季 做亮闪的你显示文摘在色彩填满的夏天,我们带着色彩去浪。而秋天带着色彩的饱和度添加了些许亮闪。闪去年秋天掀起一股枫叶红茶调的暖橘色系妆容,今年的亮闪给你闪耀的秋季。 | ryoma | 2019 | 时尚北京2019，0，9： | 0 |
| 18 | 秋的香调显示文摘秋天是一个收获的季节,充满了果子的香气,花香与果香的结合是每款香水中都不可缺少的成分。秋给我们带来了别样的芳香旅程。 | ryoma | 2019 | 时尚北京2019，0，9： | 0 |
| 19 | 镜中幻影显示文摘不敢正视你能看看穿一切的眼睛,常常把我心中的一切都能知晓,让我无法逃离你的质问。你不是我的影子,而是一个伴随我多年的伙伴。当我烦恼时,你来安慰我,当我骄傲时,你来鞭策我。于悬我不在躲避你看穿我的双眼,因为只有那双眼睛才是最了解我的。 | ryoma | 2012 | 时尚北京2012，，11： | 0 |
| 20 | 有关电影的那些事显示文摘在普通人看来我们欣赏电影无非是看跌宕起伏的故事情节,看自己喜欢的明星,看优美的画面,但是专业的演员他们对于电影来说就像是一本教科书,让他们在电影中学习,并在其中吸取能量。那么,我们应该如何学会"看"电影呢?王雅捷电影的故事更吸引我说起王雅捷,相信观众们并不陌生,她是《马大帅》中本山大叔淳朴的农村媳妇玉芬; | 刘玉方 郭嘉 ryoma | 2016 | 时尚北京2016，0，3： | 0 |
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