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| 1 | Postoperative bleeding in patients on antithrombotic therapy after gastric endoscopic submucosal dissection显示文摘AIM To investigated the relationship between postoperative bleeding following gastric endoscopic submucosal dissection(ESD) and individual antithrombotic agents.METHODS A total of 2488 gastric neoplasms in 2148 consecutive patients treated between May 2001 and June 2016 were studied. The antithrombotic agents were categorized into antiplatelet agents, anticoagulants, and other antithrombotic agents, and we included combination therapies [e.g., dual antiplatelet therapy(DAPT)]. The risk factors associated with post-ESD bleeding, namely, antithrombotic agents overall, individual antithrombotic agents, withdrawal or continuation of antithrombotic agents, and bleeding onset period(during the first six days or thereafter), were analyzed using univariate and multivariate analyses.RESULTS The en bloc resection and complete curative resection rates were 99.2% and 91.9%, respectively. Postoperative bleeding occurred in 5.1% cases. Bleeding occurred in 10.3% of the patients administered antithrombotic agents. Being male(P = 0.007), specimen size(P < 0.001), and antithrombotic agent used(P < 0.001) were independent risk factors for postoperative bleeding. Heparin bridging therapy(HBT)(P = 0.002) and DAPT/multidrug combinations(P < 0.001) were independent risk factors associated with postoperative bleeding. The bleeding rate of the antithrombotic agent continuation group was significantly higher than that of the withdrawal group(P < 0.01). Bleeding within postoperative day(POD) 6 was significantly higher in warfarin(P = 0.015), and bleeding after POD 7 was significantly higher in DAPT/multidrug combinations(P = 0.007). No thromboembolic events were reported.CONCLUSION We must closely monitor patients administered HBT and DAPT/multidrug combinations after gastric ESD, particularly those administered multidrug combinations after discharge. | Chiko Sato Kingo Hirasawa Ryonho Koh Ryosuke Ikeda Takehide Fukuchi Ryosuke Kobayashi Hiroaki Kaneko Makomo Makazu Shin Maeda | 2017 | World Journal of Gastroenterology2017，23，30： | 14 |
| 2 | Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients显示文摘BACKGROUND Persistent Helicobacter pylori(H.pylori)infection causes chronic inflammation,atrophy of the gastric mucosa,and a high risk of developing gastric cancer.In recent years,awareness of eradication therapy has increased in Japan.As H.pylori infections decrease,the proportion of gastric cancers arising from H.pylori uninfected gastric mucosa will increase.The emergence of gastric cancer arising in H.pylori uninfected patients though rarely reported,is a concern to be addressed and needs elucidation of its clinicopathological features.AIM To evaluate the clinicopathological features of early gastric cancer in H.pyloriuninfected patients.METHODS A total of 2462 patients with 3375 instances of early gastric cancers that were treated by endoscopic submucosal dissection were enrolled in our study between May 2000 and September 2019.Of these,30 lesions in 30 patients were diagnosed as H.pylori-uninfected gastric cancer(Hp UIGC).We defined a patient as H.pylori-uninfected using the following three criteria:(1)The patient did not receive treatment for H.pylori,which was determined by investigating medical recordsand conducting patient interviews;(2)Lack of endoscopic atrophy;and(3)The patient was negative for H.pylori after being tested at least twice using various diagnostic methods,including serum anti-H.pylori-Ig G antibody,urease breath test,rapid urease test,and microscopic examination.RESULTS The frequency of Hp UIGC was 1.2%(30/2462)for the patients in our study.The study included 19 males and 11 females with a mean age of 59 years.The location of the stomach lesions was divided into three sections;upper third(U),middle third(M),lower third(L).Of the 30 lesions,15 were U,1 was M,and 14 were L.Morphologically,17 lesions were protruded and flat elevated type(0-I,0-IIa,0-IIa+IIc),and 13 lesions were flat and depressed type(0-IIb,0-IIc).The median tumor diameter was 8 mm(range 2-98 mm).Histological analysis revealed that22 lesions(73.3%)were differentiated type.The Hp UIGC lesions were classified into fundic gland type adenocarcinoma(7 cases),foveolar type welldifferentiated adenocarcinoma(8 cases),intestinal phenotype adenocarcinoma(7 cases),and pure signet-ring cell carcinoma(8 cases).Among 30 Hp UIGCs,24 lesions(80%)were limited to the mucosa;wherein,the remaining 6 lesions showed submucosal invasion.One of the submucosal invasive lesions showed more than 500μm invasion.The mucin phenotype analysis identified 7 Hp UIGC with intestinal phenotype and 23 with gastric phenotype.CONCLUSION We elucidated the clinicopathological characteristics of Hp UIGC,revealing recognition not only undifferentiated-type but also differentiated-type.In addition,intestinal phenotype tumors were also observed and could be an important tip. | Chiko Sato Kingo Hirasawa Yoko Tateishi Yuichiro Ozeki Atsushi Sawada Ryosuke Ikeda Takehide Fukuchi Masafumi Nishio Ryosuke Kobayashi Makomo Makazu Hiroaki Kaneko Yoshiaki Inayama Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，20： | 7 |
| 3 | Study on the transport of suspended sediment in an open channel flow with permeable spur dikes显示文摘有刺激堤的河里的推迟的沉积的运输是为河岸保护和环境管理的一个重要问题。实验室实验被执行与可渗透的堤在一条开的隧道学习流动的特征和推迟的沉积的运输。第一,这些特征的必需品被比较可渗透、透不过的堤的斜槽实验的结果学习。在到这些特征上的堤(l) 的长度的堤(d) 之间的间隔的方面比率(d/l ) 的影响然后被调查。在这些实验,水平旋涡的性质,骚乱结构,和推迟的沉积,集中被学习。结果证明大规模水平旋涡的发展为可渗透的堤在 shear 层要求某距离,尽管他们周期性地在透不过的堤的情况中从第一个堤被产生。水平旋涡的基本结构独立于在为可渗透的堤的平衡区域的方面比率。为可渗透的堤的案例的推迟的沉积集中逐渐地在几个在上游的堤之间减少,他们在下游的区域走近一致分布,尽管在透不过的堤的情况中的那些在下游的方向是相对一致的。 | Zu-peng GU Ryosuke AKAHORI Syunsuke IKEDA | 2011 | International Journal of Sediment Research2011，26，1： | 6 |
| 4 | Histopathological validation of magnifying endoscopy for diagnosis of mixed-histological-type early gastric cancer显示文摘BACKGROUND The undifferentiated-type(UDT)component profoundly affects the clinical course of early gastric cancers(EGCs).However,an accurate preoperative diagnosis of the histological types is unsatisfactory.To date,few studies have investigated whether the UDT component within mixed-histological-type(MT)EGCs can be recognized preoperatively.AIM To clarify the histopathological characteristics of the endoscopically-resected MT EGCs for investigating whether the UDT component could be recognized preoperatively.METHODS This was a single-center retrospective study.First,we attempted to clarify the histopathological characteristics of the endoscopically-resected MT EGCs with emphasis on the UDT component.Histopathological examination investigated each lesion’s UDT component:(1)Whole mucosal layer occupation of the UDT component;(2)UDT component exposure to the surface of the mucosa;and(3)existence of a clear border between the differentiated-type and UDT components.Then,preoperative endoscopic images with magnifying endoscopy with narrowband imaging(ME-NBI)were examined to identify whether the endoscopic UDT component finding was recognizable within the area where it was present in the histopathological examination.The preoperative biopsy results and comparative relationships between endoscopic and histopathological findings were also examined.RESULTS In the histopathological examination,the whole mucosal layer occupation of the UDT component and exposure of the UDT component to the mucosal surface were observed in 67.3%(33/49)and 79.6%(39/49)of samples,respectively.A clear distinction of the border between the differentiated-type and UDT components could not be drawn in 65.3%(32/49)of MT lesions.In the endoscopic examination,the preoperative endoscopic images showed that only 24.5%(12/49)of MT EGCs revealed the UDT component within the area where it was present histopathologically.Histopathological UDT predominance was the single significant factor associated with the presence of the endoscopic UDT component finding(61.5%vs 11.1%,P=0.0009).Only 26.5%(13/49)of the lesions were diagnosed from the pretreatment biopsy as having a UDT component.Combined results of the pretreatment biopsy and ME-NBI showed the preoperative presence of the UDT component in 40.8%(20/49)of MT EGCs.CONCLUSION Recognition of a UDT component within MT EGCs is difficult even when pretreatment biopsy and ME-NBI are combined.Endoscopic resection plays a significant role in both treatment and diagnosis. | Yuichiro Ozeki Kingo Hirasawa Ryosuke Kobayashi Chiko Sato Yoko Tateishi Atsushi Sawada Ryosuke Ikeda Masafumi Nishio Takehide Fukuchi Makomo Makazu Masataka Taguri Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，36： | 5 |
| 5 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 6 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography显示文摘 | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Eriko Goto Takahisa Sato Takamasa Ohki Jun Imamura Tadashi Goto Fumihiko Kanai Naoya Kato Hitoshi Ikeda Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology2009，，： | 2 |
| 7 | Third-look endoscopy prevents delayed bleeding after endoscopic submucosal dissection under antithrombotic therapy显示文摘BACKGROUND Postoperative delayed bleeding(PDB) after gastric endoscopic submucosal dissection(ESD) is the most common adverse event in patients receiving antithrombotics even with second-look endoscopy. Moreover, with the increasing prevalence of cardiovascular and cerebrovascular diseases in an aging population with associated lifestyle-related diseases, an increasing number of patients receive antithrombotics. Several attempts have been made to prevent PDB in aging population;however, a consensus has yet to be reached.AIM To examine the efficacy of third-look endoscopy(TLE) for PDB prevention.METHODS One hundred patients with early gastric neoplasms receiving antithrombotics were prospectively enrolled and subjected to ESD with TLE between February 2017 and July 2019. The primary endpoint was PDB rate, which was compared with our preset threshold. Furthermore, we divided the bleeding period into early-and late-onset PDB(E-PDB and L-PDB, respectively) and analyzed its rate. As a secondary analysis, we compared PDB rates with those of a historical control group, using propensity score matching, and calculated the PDB rates per antithrombotic agent use in each group.RESULTS In total, 96 patients and 114 specimens were finally evaluated. The overall PDB rate was 7.9%(9/114) [90%CI: 4.7-13.1, P = 0.005], while the late-and early-onset PDB rates(L-PDB and E-PDB) were 5.3% [90%CI: 2.7-9.9, P < 0.0001] and 2.6% [90%CI: 1.1-6.4, P = 0.51], respectively. Propensity score matching generated 58 matched pairs for TLE and control groups. No differences were found in overall PDB incidence(10.3% vs 20.7%, P = 0.12), whereas L-PDB occurrence significantly differed(5.2% vs 17.2%, P = 0.04) between groups. Considering antithrombotics' use, the overall PDB rate was higher for direct oral anticoagulants and multiple antithrombotics in the control group, while L-PDB incidence was lower in the TLE group for these agents(8.7% vs 23.1% and 5.0% vs 29.4%, respectively).CONCLUSION TLE for gastric ESD reduces overall PDB, and especially L-PDB incidence, among patients receiving antithrombotics. | Ryosuke Ikeda Kingo Hirasawa Chiko Sato Yuichiro Ozeki Atsushi Sawada Masafumi Nishio Takehide Fukuchi Ryosuke Kobayashi Makomo Makazu Masataka Taguri Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，41： | 2 |
| 8 | Value of whole-body FDG PET in management of lung cancer显示文摘 | Kotaro Higashi Ichiro Matsunari Yoshimichi Ueda Ryosuke Ikeda Jianfei Guo Manabu Oguchi Hisao Tonami Itaru Yamamoto | 2003 | Annals of Nuclear Medicine2003，，1： | 1 |
| 9 | Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly显示文摘 | Kazuaki Tejima Ryota Masuzaki Hitoshi Ikeda Haruhiko Yoshida Ryosuke Tateishi Yosuke Sugioka Yukio Kume Tomoko Okano Tomomi Iwai Hiroaki Gotoh Sachiko Katoh Atsushi Suzuki Yukako Koike Yutaka Yatomi Masao Omata Kazuhiko Koike | 2010 | Journal of Gastroenterology2010，，8： | 1 |
| 10 | Relationship Between Carotid Intima-Media Thickness and Silent Cerebral Infarction in Japanese Subjects With Type 2 Diabetes显示文摘 | Nomura Kazuhiro Hamamoto Yoshiyuki Takahara Shiho Kikuchi Osamu Honjo Sachiko Ikeda Hiroki Wada Yoshiharu Nabe Koichro Okumra Ryosuke Koshiyama Hiroyuki | 2010 | Diabetes Care2010，，1： | 1 |
| 11 | Circulating omentin is associated with coronary artery disease in men显示文摘 | Rei Shibata Noriyuki Ouchi Ryosuke Kikuchi Ryotaro Takahashi Kyosuke Takeshita Yoshiyuki Kataoka Koji Ohashi Nobuo Ikeda Shinji Kihara Toyoaki Murohara | 2011 | Atherosclerosis2011，，2： | 1 |
| 12 | Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects显示文摘 | Takuji Kurimoto Takata Masashi Ryosuke Kashimoto Yuichi Tagami Hidehiro Oku Shinichirou Oono Osamu Mimura Tsunehiko Ikeda Norio Okamoto | 2010 | Clinical Ophthalmology . 2010 (defa)2010，，： | 1 |
| 13 | Clinicopathologic study of small hepatocellular carcinoma with microscopicsatellite nodules to determine the extent of tumor ablation by local therapy显示文摘 | Kozo Ikeda Toshihito Seki Hideto Umehara Ryosuke Inokuchi Toru Tamai Noriko Sakaida Yoshiko Uemura Yasuo Kamiyama Kazuichi Okazaki | 2007 | International Journal of Oncology2007，，3： | 1 |
| 14 | A rotarod test for evaluation of motor skill learning显示文摘 | Hiromi Shiotsuki Kenji Yoshimi Yasushi Shimo Manabu Funayama Yukio Takamatsu Kazutaka Ikeda Ryosuke Takahashi Shigeru Kitazawa Nobutaka Hattori | 2010 | Journal of Neuroscience Methods2010，，2： | 1 |
| 15 | Circulating omentin is associated with coronary artery disease in men显示文摘 | Rei Shibata Noriyuki Ouchi Ryosuke Kikuchi Ryotaro Takahashi Kyosuke Takeshita Yoshiyuki Kataoka Koji Ohashi Nobuo Ikeda Shinji Kihara Toyoaki Murohara | 2011 | Atherosclerosis2011，，2： | 1 |
| 16 | Clinicopathologic study of small hepatocellular carcinoma with microscopicsatellite nodules to determine the extent of tumor ablation by local therapy显示文摘 | Kozo Ikeda Toshihito Seki Hideto Umehara Ryosuke Inokuchi Toru Tamai Noriko Sakaida Yoshiko Uemura Yasuo Kamiyama Kazuichi Okazaki | 2007 | International Journal of Oncology2007，，3： | 1 |
| 17 | Investigation of Experimental Con6guration for Electron Bernstein Wave Heating on LHD显示文摘为在 LHD 上由使用加热的存在电子回旋加速器(ECH ) 加热天线的电子伯恩斯坦波浪(EBW ) 的试验性的配置的调查被执行。由使用在更低的港口安装的一条天线,指导倾斜的发射非凡(X---) 从高磁场方面(HFS ) 的模式是可得到的。自从折射索引的平行部件(因为磁场的不同类, N ||) 在繁殖期间变化,当发射 X 模式穿过甚至 N || 是的基本电子回旋加速器回声(ECR ) 层时, N || 能是零中午零开始。处于如此的一个条件,如果电子密度在某个水平上面,没有外面被抑制并且能对在 Doppler 被吸收的 EBW 变换模式,倾斜地发射的 X 模式能传递基本 ECR 层转移 ECR 层。由使用在水平港口安装的一条天线,向在稠密上的血浆的从更低的磁场方面(LFS ) 的倾斜的发射是可得到的。经由平常的模式(O) 的模式变换过程的 EBW 的刺激非凡的模式(X) 电子伯恩斯坦波浪(B) 被期望, O 模式向一个适当方向发射。O-X-B 模式变换率和力量免职的区域被改变磁场力量和发射方向调查。调查的结果建议在核心区域的有效加热由使用存在天线是困难的。发射天线的最后的镜子的重新整理可以被需要。 | Hiroe IGAMI Ryosuke IKEDA Hiromi TAKAHASHI Yasuo YOSHIMURA Takashi SHIMOZUMA Shin KUBO Hitoshi TANAKA Kazunobu NAGASAKI Takashi MUTOH the LHD Experiment Group | 2009 | Plasma Science and Technology2009，11，4： | 0 |
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