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| 1 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 2 | Strain-independen temperature measurement using a type-land type - ⅡA optical fiber Bragg grating combination显示文摘 | S Pal T Sun K T V Grattan S A Wade S F Collins G W Baxter B Dussardier and G Monnom | 2004 | Rev Sci Instrum2004，75，： | 1 |
| 3 | A new initiative on precision medicine显示文摘 | Collins F S Varmus H | 2015 | The New EnglandJournal of medicine2015，372，9： | 1 |
| 4 | Finding the missing heritability of complex diseases 显示文摘 | MANOLIO T A COLLINS F S COX N J | 2009 | Nature2009，461，： | 1 |
| 5 | Pyoderma gangremosum显示文摘 | POWELL F C COLLINS S | 2000 | Clin Dermatol2000，18，3： | 1 |
| 6 | A vision for the future of genomics research 显示文摘 | COLLINS F S GREEN E D GUTFMACHER A E | 2003 | Nature2003，422，6934： | 1 |
| 7 | Risk assess- ment for benzaopyrene 显示文摘 | Collins J F Brown J P Dawson S V | 1991 | Regulatory Toxicology and Pharmacology1991，13，： | 1 |
| 8 | Cognitive existential coupletherapy for newly diagnosed prostate cancer patients and their part-ners:A descriptive pilot study显示文摘 | Collins A L Bloch S Annette F | 2011 | Psycho-oncology2011，10，2： | 1 |
| 9 | Mechanical proper- ties and microstructure analysis of fly ash geopolymeric recy- cled concrete显示文摘 | Shi X S Collins F G Zhao X L | 2012 | J Hazard Mater2012，20，29： | 1 |
| 10 | Rapamycin activates autophagy in hutchinson-gilford progeria syndrome:Implications for normal aging and age-dependent neurodegenerative disorders显示文摘 | Graziotto J J Cao K Collins F S | 2012 | Autophagy2012，8，1： | 1 |
| 11 | Synergistic activa- tion of estrogen receptor with combinations of environmental chemicals(estrogen mimicking pollutants linked to human disea ses)显示文摘 | Arnold S F Klotz D M Collins B M | 1996 | Science1996，272，： | 1 |
| 12 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 13 | The humangenome project:lessons from large-scale biology显示文摘 | COLLINS F S MORGAN M PATRINOS A | 2003 | Sci-ence2003，300，5617： | 1 |
| 14 | Numerical investigation of steady flow in proximal and distal end-to-side anastomoses显示文摘 | Henry F S Collins M W Hughes P E | 1996 | Journal of Biomechanical Engineering1996，118，： | 1 |
| 15 | Variations on a theme: Cataloging human DNA sequence variation 显示文摘 | Collins F S Guyer M S Chakravarti A | 1997 | Science1997，278，： | 1 |
| 16 | Differential interaction of natural and synthetic estrogens with extracellular binding proteins in a yeast estrogen screen显示文摘 | ARNOLD S F COLLINS B M ROBINSON M K | 1996 | Steroids1996，61，11： | 1 |
| 17 | Genomic medicine-an updated primer显示文摘 | FEERO W G GUTTMACHER A E COLLINS F S | 2010 | N Engl J Med2010，362，21： | 1 |
| 18 | Patient-centered outcomes researchinstitute: the intersection of science and health care显示文摘 | CLANCY C COLLINS F S | 2010 | Science Translational Medicine2010，2，37： | 1 |
| 19 | A vision for the future of genomics research显示文摘 | COLLINS F S GREEN E D GUTTMACHER A E | 2003 | Nature2003，422，6934： | 1 |
| 20 | Flavour retention by lipids measured in a fresh cheese matrix显示文摘 | Piraprez G Herent M F Collin S | 1998 | Food Chemistry1998，61，12： | 1 |
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