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| 1 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 2 | On the convergence of Tabu search显示文摘 | Hanafi S | 2000 | Journal of Heuristic2000，，7： | 2 |
| 3 | IP Virtual Private Networks 显示文摘 | Hills S McGlaughlin D Hanafi N | 2000 | BT Technology Journal2000，18，3： | 1 |
| 4 | Intraumbilical injection of three different uterotonics in the management for retained placenta 显示文摘 | HARARA R HANAFY S ZIDAN MS | 2011 | J Obstet Gynaecol Res2011，37，9： | 1 |
| 5 | A silicon nanocrystals based memory显示文摘 | Rana F Hanafi H | 1996 | Appl Phys Lett1996，68，10： | 1 |
| 6 | A contribution to the simulation and design optimization of photovoltaic systems显示文摘 | Jaboori M G Hanafy S M | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 7 | Scatter Search for the 0-1 Multidimensional Knapsack Problem显示文摘 | Hanafi S Wilbaut C | 2008 | Journal of Mathematical Modeling and Algorithms2008，7，2： | 1 |
| 8 | Catalytic con-version of ethanol and isop ropanol over the Mn2 O3/AI9O3system doped with Na20 显示文摘 | Doheim M M Hanafy S A El-Shobaky G A | 2002 | Materials Letters2002，55，5： | 1 |
| 9 | Are long-term vegetation dynamics useful in monitoring and assessing desertification processes in the arid steppe, southern Tunisia显示文摘 | Hanafi A Jauffret S | 2008 | Journal of Arid Environments2008，72，4： | 1 |
| 10 | Are long-term vegetation dynamics useful in monitoring and assessing desertification processes in the arid steppe, southern Tunisia显示文摘 | Hanafi A Jauffret S | 2008 | Journal Arid Environments2008，72，： | 1 |
| 11 | Tabu Search and Finite Convergence显示文摘 | F Glover S Hanafi | 2002 | Discrete Applied Mathematics2002，119，3： | 1 |
| 12 | Baclofen ester and carbamate prodrug candidates:a simultaneous chromatographic assay,resolution optimized with DryL ab显示文摘 | Hanafi R Mosad S Abouzid K | 2011 | J Pharm Biomed Anal2011，56，3： | 1 |
| 13 | On the Convergence of Tabu Search显示文摘 | S Hanafi | 2000 | Journal of Heuristics2000，，7： | 1 |
| 14 | Surface properties of silica produced by thermal treatment of rice husk ash 显示文摘 | HANAFI S ABO-EL-ENEIN S A IBRAHIM D M | 1980 | ThermochimActa1980，37，： | 1 |
| 15 | Tabu search and finite convergence 显示文摘 | GLOVER F HANAFI S | 2002 | Discrete Applied Mathematics2002，119，12： | 1 |
| 16 | Genetic algorithm with iterated lo- cal search for solving a location-routing problem显示文摘 | Derbel H Jarboui B Hanafi S | 2012 | Expert Systems with Applications2012，39，3： | 1 |
| 17 | reversible pulmonary hypertension in heart transplant candidates pretransplant evaluation and outcome after orthotopic heart transplantation显示文摘 | Klotz S Deng MC Hanafy D | 2003 | Eur J heart failure2003，，5： | 1 |
| 18 | Character- ization and Catalytic Activities of ZrO2-TiO2 Supported Hy- drodesulfurization Catalysts显示文摘 | Hanafi S A E1-Syed H A Elmelawy M S | 2009 | PetSci Technol2009，27，1： | 1 |
| 19 | An iterative variable-based fixation heuristic for the 0-1 multidimensional knapsack problem显示文摘 | Wilbaut C Salhi S Hanafi S | 2009 | European Journal of Operational Research2009，199，2： | 1 |
| 20 | The effects of a silane coupling agent on curing characteristics and mechanical properties of bamboo fibre filled natural rubber composites 显示文摘 | Ismail Hanafi Shuhelmy S Edyham M R | 2002 | European Polymer Journal2002，38，1： | 1 |
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