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| 1 | Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics显示文摘AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of polyps.Hereditary forms represent at least 21% of cases.Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of tumors.CONCLUSION:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite stable.Cyclin E might be a poor prognosis factor. | Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicana strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients显示文摘 | Perea S Lopez-Ribot JL Kirkpatrick WR | 2001 | Antimicrob Agents Chemother2001，45，10： | 1 |
| 3 | Azole resistance in Candida albicans 显示文摘 | Perea S | 2000 | Rev Esp Quimioter2000，13，3： | 1 |
| 4 | Efficacy of caspofungin alone and in combination with voriconazole in guinea pig model of invasive aspergillosis显示文摘 | Kirkpatrick W R Perea S Coco B J | 2002 | Antimicrob Agents Chemother2002，46，： | 1 |
| 5 | Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients显示文摘 | Rafael Perelló Ona Escoda Silvia Camón òscar Miró Marta Casta?eda Asunción Moreno Maria ángeles Marcos Verónica Perea Natalia Alcolea Miquel Sánchez Josep Maria Gatell Esteban Martínez | 2014 | Enfermedades Infecciosas y Microbiologia Clinica2014，，： | 1 |
| 6 | Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients显示文摘 | McAtee RK Perea S | 1999 | Antimicrob Agents Chemother1999，43，7： | 1 |
| 7 | In vitro activities of terbinafine in combination with fluconazole,itraconazole,voriconazole,and posaconazole against clinical isolates of Candida glabrata withdecreased susceptibility to azoles显示文摘 | Perea S Gonzalez G Fothergill AW | | 0，，05： | 1 |
| 8 | CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphoryla- tion and exhibits anticancer properties both in vitro and in vi- vo显示文摘 | PEREA S E REYES O BALADRON I | 2008 | Mol Cell Bioehem2008，316，12： | 1 |
| 9 | Genotypic bases of EGFR inhibitors pharmacological actions显示文摘 | Perea S Oppenheimer D Amador M | 2004 | J Clin Oncol2004，22，： | 1 |
| 10 | The Value of the Modified Early Warning Score and Biochemical Parame- ters as Predictors of Patient Outcome in Acute Medical Ad- mission:A Prospective Study显示文摘 | Perea Y S Ranasinghe P Adikare A M | 2011 | Acute Med2011，10，3： | 1 |
| 11 | Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosis显示文摘 | KirkpatrickWR Perea S Coco BJ | 2002 | Antimicrob Agents Chemother2002，46，8： | 1 |
| 12 | Invasive Aspergillus infections in hematologic malignancy patients显示文摘 | Perea S Patterson TF | 2002 | Semin Respir Infect2002，17，2： | 1 |
| 13 | Effect of kramecyne on the inflammatory response in lipopolysaccharide-stimulated peritoneal macro-phages 显示文摘 | E Sanchez-Miranda J Lemus-Bautista S Perea | 2013 | Evid Based Complement Alternal Med2013，13，3： | 1 |
| 14 | Oxytocin signaling in mouse taste buds显示文摘 | SINCLAIR M S PEREA -MARTINEZ I DVORYANCHIKOV G | 2010 | PLoS One2010，5，8： | 1 |
| 15 | Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients显示文摘 | Lopez-Ribot JL Kirkpatrick WR | 2001 | Antimicrob Agents Chemother2001，45，10： | 1 |
| 16 | Comparison of high performance liquid chromatographic and microbiologic methods for the determination of voriconazole levels in plasma显示文摘 | PEREA S PENNICK GJ MODAK A | 2000 | Antimicrob Agents Chemother2000，44，5： | 1 |
| 17 | An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors显示文摘 | Amador ML Oppenheimer D Perea S | 2004 | Cancer Res2004，64，24： | 1 |
| 18 | In vitro activities of terbinafine in combination with fluconazole,itraconazole,voriconazole,and posaconazole against clinical isolates of Candida glabrata with decreased susceptibility to azole显示文摘 | Perea S Gonzalez G Annette W | 2002 | J Clin Microbiol2002，40，： | 1 |
| 19 | Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients显示文摘 | Perea S López-Ribot JL Kirkpatrick WR | 2001 | Antimicrob Agents Chemother2001，45，10： | 1 |
| 20 | Comparison of high-performance liquid chromatographic and microbiological methods for determination of voriconazole levels in plasma显示文摘 | Perea S Pennick G J Modak A | 2004 | Antimicrob Agents Chemother2004，44，5： | 1 |
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