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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | Gastric intestinal metaplas a: subtypes and natural history 显示文摘 | El-Zimaitv H M Ramchatesingh J Saeed M A | 2001 | J Clin Pathol2001，54，9： | 1 |
| 3 | Feature selection based on class-dependent densities for high-dimensional bi-nary data显示文摘 | JAVED K BABRI H A SAEED M | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，3： | 1 |
| 4 | Improved production of Pseudomonas aeruginosa uricase by optimization of process parameters through statistical experimental designs 显示文摘 | Abdel-Fattah Y R Saeed H M Gohar Y M | 2005 | Process Biochemistry2005，40，： | 1 |
| 5 | Association of Gprotein beta-3 subunit gene ( GNB3 ) T825 allele with Type Ⅱ diabetes显示文摘 | KIANI J G SAEED M PARVEZ S H | 2005 | Neuro Endocrinol Lett2005，26，2： | 1 |
| 6 | Osteoblastic cells:differentiation and trans-differentiation显示文摘 | Kassem M Abdallah BM Saeed H | | 0，，： | 1 |
| 7 | Death receptor activation complex: it takes two to active TNF receptor 1显示文摘 | M Saeed S Ying H | 2003 | Cell Cycle2003，2，6： | 1 |
| 8 | Fatigue crack growth and life prediction of a single interference letted holed plate 显示文摘 | Chakherlou T N Mirzajanzadeh M Saeed K H | 2010 | Fatigue &Fracture of Engineering Materials&Structures2010，33，10： | 1 |
| 9 | Emergence of methicillin-resistant Staphylococcus aureus as a community pathogen显示文摘 | Bukharie H A Abdelhadi M S Saeed I A etal | 2001 | Diagn Microbiol Infect Dis2001，40，12： | 1 |
| 10 | Measurement of the distribution volume of gadopentetate dimeglumine at EP MRI to quantity myocardial infarction:comparison with 99mTc-DTPA autoradiography in rats显示文摘 | Arheden H Saeed M Higgins CB | 1999 | Radiology1999，211，： | 1 |
| 11 | Effects of sweetpotato flour on quality of cookies 显示文摘 | Saeed S Ahmad M M Kausar H Parveen S Masih S Salam A | 2012 | Journal of Agricultural Research2012，50，4： | 1 |
| 12 | Excessive iodine intake, water chemicals and endemic goitre in a Sudanese coastal area显示文摘 | MEDANI A M M H ELNOUR A A SAEED A M | 2013 | Public Health Nutr2013，16，9： | 1 |
| 13 | Experimental infection of laying hens with Salmonella enteritidis strains that express different types of fimbriae显示文摘 | Thiagarajan D Thacker H L Saeed A M | 1996 | Poult Sci1996，75，： | 1 |
| 14 | Development of somaelones in sugarcane genotype BF - 162 and assessment of variability by random amplified polyrnorphic DNA (RAPD) and simple sequence repeats (SSR) markers in selected red rot resistant somaelones 显示文摘 | Shahid M T H Khan F A Saeed A Aslam M Rasul F | 2012 | African Journal of Bioteehnology2012，11，15： | 1 |
| 15 | Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking 显示文摘 | Saeed M Kadioglu O Khalid H | 2015 | J Nutr Biochem2015，26，1： | 1 |
| 16 | Orbital irradiation for Graves' ophthahnopathy: is it safe? A long-term follow-up study 显示文摘 | Wakelkamp I M Tan H Saeed P | 2004 | Ophthalmology2004，111，8： | 1 |
| 17 | Irrigation effects on the growth, yield and water use efficiency of alfalfa 显示文摘 | Saeed L A M EL--Nadi A H | 1997 | Irrigation Science1997，17，2： | 1 |
| 18 | Improved production of Beudomonas aeruginosa uricase by optimization of process parameters through statistical experimental designs显示文摘 | ABDEL FATTAH Y R SAEED M H GOHAR Y M | 2005 | Process Biochemistry2005，40，11： | 1 |
| 19 | Normal and infarcted myocardium:differentiation with cellular uptake of manganese at MR imaging in a rat model显示文摘 | BREMERICH J SAEED M ARHEDEN H | 2000 | Radiology2000，216，2： | 1 |
| 20 | Acanthamoeba-bacteria: a model to study host interaction with human pathogens显示文摘 | Sandstr? m G Saeed A Abd H | 2011 | Curr Drug Targets2011，12，7： | 1 |
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