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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | Biological fixation of commin- uted subtrochauteric fractures with proximal femur locking compres- sion plate显示文摘 | Saini P Kumar R Shekhawat V | 2013 | Injury2013，44，2： | 1 |
| 3 | Defluoridation of wastewaters u- sing waste carbon slurry显示文摘 | GUPTA V ALI I SAINI V | 2007 | Water Research2007，41，15： | 1 |
| 4 | Is there Supernova Evidence for Dark Energy Metamorphosis? 显示文摘 | ALAM U SAHNI V SAINI T D | 2004 | Mon Not Roy Astron Soc2004，354，： | 1 |
| 5 | Endobronchial tuberculosis显示文摘 | Kashyap S Mohapatra PR Saini V | | 0，，04： | 1 |
| 6 | Immunological methods for quantifying free and totalserum IgE levels in allergy patients receiving Omali-zumab (Xolair) therapy 显示文摘 | HAMILTON R G MARCOTTE G V SAINI S S | 2005 | J Immunol Methods2005，303，： | 1 |
| 7 | Anesthetic management and one-year mortality after noncardiac surgery 显示文摘 | Monk T G Saini V Weldon B C | 2005 | Anesth Analg2005，100，1： | 1 |
| 8 | Role of leptin and adiponectin in insulin resistance 显示文摘 | Yadav A Kataria NA Saini V | 2013 | Clini Chim Acta2013，417，18： | 1 |
| 9 | MCP-1:chemoattractant with a role beyond immunity:a review显示文摘 | Yadav A Saini V Arora S | 2010 | Clin Chim Acta2010，411，2122： | 1 |
| 10 | Carbohydrate metabolism during tuber initiation in potato:a transient surge in invertase activity marks the stolon to tuber transition显示文摘 | Minhas J S Rai V K Saini H S | 2004 | Potato Research2004，47，5： | 1 |
| 11 | Upregulation of miR - 23a - 27a - 24 - 2 cluster induces caspase - dependent and -independent apoptosis in human embryonic kidney cells 显示文摘 | Chhabra R Adlakha YK Hariharan M Scaria V Saini N | 2009 | PLoS One2009，4，： | 1 |
| 12 | Multifunctional novel Diallyl disulfide (DADS) derivatives with beta- amyloid-reducing, cholinergie, antioxidant and metal chelating properties for the treatment of Alzheimer 's disease显示文摘 | Manral A Saini V Meena P | 2015 | Bioorg Med Chem2015，23，19： | 1 |
| 13 | Removal of cadmium and nickel from wastewater using bagasse fly ash-a sugar industry waste显示文摘 | GUPTA V K JAIN C K ALI I SHARICIA M SAINI V K | 2003 | Water Res2003，37，16： | 1 |
| 14 | Anesthetic manage- ment and one year mortality after noncardiac surgery显示文摘 | MONK T G SAINI V WELDON B C | 2005 | Anesth Analg2005，100，1： | 1 |
| 15 | Studies on the Indian species of Athalia Leach (Hymenoptera:Tenthredinidae:Allantinae)显示文摘 | Saini M S Vasu V | 1997 | Polish Journal of Entomology1997，66，： | 1 |
| 16 | Cytokines in recurrent pregnancy loss显示文摘 | Saini V Arora S Yadav A | 2011 | Clinica Chimica Acta2011，412，910： | 1 |
| 17 | Endobronchial tuberculosis 显示文摘 | KASHYAP S MOHAPATRA PR SAINI V | 2003 | Indian J Chest Dis Allied Sci2003，45，4： | 1 |
| 18 | Removal of Dyes from Wastewater Using Bottom Ash 显示文摘 | Gupta V K Ali I Saini V K | 2005 | Industrial & Engineering Chemistry Research2005，44，10： | 1 |
| 19 | Endobronchial tuberculosis显示文摘 | Kashyap S Mohapatra PR Saini V | 2003 | Indian J Chest Dis Allied Sei2003，45，4： | 1 |
| 20 | Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer显示文摘 | Majid S Dar AA Saini S Chen Y Shahryari V Liu J | 2010 | Cancer Res2010，70，7： | 1 |
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