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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Whole body imaging in blunt rnultisystern trauma patients without obvious signs of injury: results of a prospective study显示文摘 | Salim A Sangthong B Martin M el al | 2006 | Arch Surg2006，141，5： | 1 |
| 3 | Tube thorocostomy: management and outcome in patients with penetrating chest trauma显示文摘 | Muslim M Bilal A Salim M | 2008 | J Ayub Med Coil Ablmttabad2008，20，4： | 1 |
| 4 | Fabrication, fouling and foulant analyses of asymmetric polysulfone (PSF) ultra{iltration membrane fouled with natural or- ganic matter (NOM) source waters显示文摘 | Zularisam A W Ismail A F Salim M R | 2007 | Journal nf Mem- brane Science2007，299，97： | 1 |
| 5 | A review of the effects of emerging contaminants in wastewater and options for their removal显示文摘 | Bolong N Ismail A Salim M R | 2009 | Desalination2009，239，1： | 1 |
| 6 | Oxidative stress: a potential recipe for anxiety, hypertension and insulin resistance显示文摘 | Salim S Asghar M Chugh G et a| | | Brain Res0，1359，： | 1 |
| 7 | Human biliverdin reductase is autophosphorylated,and phosphorylation is required for bilirubin formation显示文摘 | Salim M Brown-Kipphut B A Maines M D | 2001 | J Biol Chem2001，276，10： | 1 |
| 8 | The effects of natural organic matter ( NOM ) fractions on fouling characteristics and flux recovery of ultrafihration membranes 显示文摘 | ZULARISAM A W ISMAIL A F SALIM M R | 2007 | Desalination2007，212，： | 1 |
| 9 | Normal electrocardi- ography and serum troponin 1 levels preclude the presence of clini- cally significant blunt cardiac injury显示文摘 | Velhamos GC Karaiskakis M Salim A | 2003 | J Tranma2003，54，1： | 1 |
| 10 | Development and characterization of novel charged surface modification macromolecule to polyethersulfone hollow fiber membrane with polyvinylpyrrolidone and water显示文摘 | N Bolong A F lsmail M R Salim | 2009 | Joumal of Membrane Science2009，331，： | 1 |
| 11 | The influenced of PAC, zeolite, and Moringa oleifera as biofouling reducer (BFR) on hybrid membrane bioreaetor of palm oil mill effluent (POME) 显示文摘 | Damayanti A Ujang Z Salim M R | 2011 | Bioresource Technology2011，102，6： | 1 |
| 12 | Non-linear Modeling and Cascade Control of an Industrial Pneumatic Actuator System 显示文摘 | RAHMAT M F SALIM S N S FAUDZI A A M | 2011 | Australian Journal of Basic and Applied Sciences2011，5，8： | 1 |
| 13 | Intraabdominal injury is common in blunt trauma patients who sustain spinal cord injury显示文摘 | Salim A Ottochian M Gertz R J | 2007 | Am Surg2007，73，10： | 1 |
| 14 | X-ray photoelectron and Auger spectroscopy study of copper-sodium- germanate glasses 显示文摘 | HUSSA1N Z SALIM M A KHAN M A KHAWAJA E E | 1989 | Journal of Non-Crystalline Solids1989，110，1： | 1 |
| 15 | The effects of natural organic matter(NOM ) fractions on fouling characteristics and flux recovery of ultrafiltration membranes 显示文摘 | Zularisam A W Ismai A F Salim M R | 2007 | Desalination2007，212，13： | 1 |
| 16 | The effects ofnatural organic matter(NOM)fractions on fouling characteristicsand flux recovery of ultrafiltration membranes显示文摘 | Zularisam A W IsmailA F Salim M R | 2007 | Desalination2007，212，123： | 1 |
| 17 | Development and characterization of novel charged surface modification macromole cule to polyethersulfone hollow fiber membrane with polyvinylpyrrolidone and water显示文摘 | Bolong N Ismail A F Salim M R | | 0，，1： | 1 |
| 18 | The effects of natural organic matter (NOM) fractions on fouling characteristics and flux recovery of ultrafiltration membranes显示文摘 | A W Zularisam A F Ismail M R Salim | 2007 | Desalination2007，212，13： | 1 |
| 19 | Fabrica- tion, fouling and foulant analyses of asymmetric polysulfone (PSF) ultrafiltration membrane fouled with natural organic matter (NOM) source waters 显示文摘 | A W Zularisam A F Ismail M R Salim | 2007 | Journal of Membrane Science2007，299，12： | 1 |
| 20 | Extended fault-location formulation for power distribution systems显示文摘 | Salim R H Resener M Filomena A D | 2009 | Power Delivery IEEE Trans on Industrial Electronics2009，24，2： | 1 |
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