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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Influence of mode of delivery on gut microbiota composition in seven years old children显示文摘 | Salminen S Gibson GR McCaetney AL | 2004 | Gut2004，53，9： | 1 |
| 3 | The role of the intestinal microflora for the development of the immune system in early childhood显示文摘 | Isolauri E Salminen S | 2002 | Eur J Nutr2002，411，： | 1 |
| 4 | Tissue response to polyglycolide,polydioxanone,polylevolactide,and metallic pins in cancellous bone:An experimental study on rabbits显示文摘 | Pihlajamaki H Salminen S Laitinen O | 2006 | J Orthop Res2006，24，： | 1 |
| 5 | Correlations between traffic, occupational, sports, and home accidents 显示文摘 | SALMINEN S HEISKANEN M | 1997 | Accid Anal Prev1997，29，1： | 1 |
| 6 | Probiotics: a role in the treatment of intestinal infec- tion and inflmmation 显示文摘 | SOLAURI E KIRJAVAINEN P V SALMINEN S | 2002 | Gut2002，50，3： | 1 |
| 7 | Probiotics in primary prevention of atopic disease:a randomised placebo-controlled trial显示文摘 | KALLIOMKI M SALMINEN S ARVILOMMI H | 2001 | The Lancet2001，357，9262： | 1 |
| 8 | Biologic control of food carcinogen using Lactobacillus GG 显示文摘 | EI-NEZAM H S SALMINEN S AHOKAS J T | 1996 | Neture Today1996，31，： | 1 |
| 9 | Basking in reflected glory: Using customer reference relationship to build reputation in indus- trial markets显示文摘 | Helm S and Salminen R T | 2010 | Industrial Marketing Management2010，39，5： | 1 |
| 10 | Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial 显示文摘 | Rautava S Collado MC Salminen S Isolauri E | 2011 | Neonatology2011，102，3： | 1 |
| 11 | Novel probiot- ics and prebio tics:road to the market显示文摘 | Kumar H Salminen S Verhagen H | 2015 | Curr Opin Bio- technol2015，32，： | 1 |
| 12 | The normal faecal microflora does not affect the adhesion of probiotic bacteria in vitro显示文摘 | OUWEHAND A C NIENI P SALMINEN S J | 1999 | FEMS Microbiol Lett1999，177，： | 1 |
| 13 | Two decades of alexithymia显示文摘 | Salminen JK Saarijarvi S Aarela E | 1995 | J Psychosom Res1995，39，7： | 1 |
| 14 | Fifteen-year outcome of laparo- scopic and open Nissen fundoplication: a randomized clinical trial 显示文摘 | Salminen P Hurme S Ovaska J | 2012 | Ann Thorac Surg2012，93，1： | 1 |
| 15 | Specif- ic strains of probiotic bacteria are efficient in removal of several different eyanobacterial toxins from solution 显示文摘 | Nybom S M K Salminen S J Meriluoto J A O | 2008 | Toxicon2008，52，2： | 1 |
| 16 | The binding of sodium and potassium ions by heparin显示文摘 | Salminen S Luomanmaki K | 1963 | Biochim Biophys Acta1963，69，1963： | 1 |
| 17 | Binding rather than metabolism may explain the interaction of two foodgrade lactobacillus strains with zearalenone and its derivative azearalenol显示文摘 | El-Nezami H Polychronaki N Salminen S | 2002 | Applied and Environment Microbiology2002，68，7： | 1 |
| 18 | Probiotics: an overview of beneficial effects 显示文摘 | OUWEHAND A C SALMINEN S ISOLAURI E | 2002 | Antonie Van Leeuwenhoek2002，82，14： | 1 |
| 19 | Probiotics:how are they defined?显示文摘 | Salminen S Ouwehand A BennoY | 1999 | Trends in Food Science &Technology1999，，10： | 1 |
| 20 | Method for determining plutonium in air filters in de- tection of nuclear activities 显示文摘 | SALMINEN S OUTOLA I JAAKKOLA T | 2004 | Radiochim Acta2004，92，： | 1 |
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