|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro?II mesh in Lichtenstein hernioplasty显示文摘 | Sven Bringman Timo-Jaakko Heikkinen Staffan Wollert Johanna ?sterberg Sam Smedberg H?kan Granlund Stig Ramel G?ran Fell?nder Bo Anderberg | 2004 | Hernia2004，，2： | 1 |
| 3 | Identification of two lipid binding proteins from liver Of Gallus domestieus 显示文摘 | Sams G H Hargis B M Hargis P S | 1991 | Comp Biochem Physiol B1991，99，1： | 1 |
| 4 | Network Char- acteristics and the Value of Collaborative UseGener- ated Content显示文摘 | SAM R KANE G C LURIE N H | 2012 | Marketing Science2012，31，3： | 1 |
| 5 | Geographically and temporally weighted likelihood regression: Exploring the spatiotemporal determinants of land use change显示文摘 | Wrenn D H Sam A G | 2014 | Regional Science and Urban Economics2014，44，1： | 1 |
| 6 | Use of the Safety Monitor in Operational Decision-Making at a Nuclear Generating Facility显示文摘 | Shan (Sam) H Chien Thomas G Hook Roger J Lee | 1998 | Reliability Engineeringand System Safety1998，62，2： | 1 |
| 7 | 欧亚苔原旅鼠过去与现在的周期波动显示文摘瑞典-俄罗斯94’苔原生态考察的目的之一是对整个欧亚苔原的西伯利亚旅鼠种群波动进行描述。为了弥补缺乏重复取样,我们采用了4种不同估计方法来确定不同样地旅鼠种群的波动相位:①单位时间内所捕获的旅鼠数目;②旅鼠种群的年龄结构;③重要采食植物的化学防御水平;④田鼠科动物啮食柳树茎所留下疤痕的年龄分布(样地过去旅鼠波动的'历史档案')。我们对12个样地做了调查,仅提供其中4个的数据和结果。4种不同方法的结果在很大程度上相吻合。我们认为当取样只能在1年之内进行时,本文所采用的将几种方法相结合是可行的,但必须强调,所有比较研究样地中的取样要在相同的物候学阶段进行。我们在本文及另文所报道的数据表明西伯利亚旅鼠的当地种群在广大的欧亚苔原上没有表现出同周期的动态。 | Njell Danell Sam Erlinge Dennis Hasselquist Gran Hgstedt Evn-BrittOlosson Tarald Seldal Mikael svensson 王玉山 | 1999 | 人类环境杂志1999，28，3： | 1 |
| 8 | Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro?II mesh in Lichtenstein hernioplasty显示文摘 | Sven Bringman Timo-Jaakko Heikkinen Staffan Wollert Johanna ?sterberg Sam Smedberg H?kan Granlund Stig Ramel G?ran Fell?nder Bo Anderberg | 2004 | Hernia2004，，2： | 1 |
| 9 | A glutarimide alkaloid from croton membranaceus显示文摘 | ABOAGYE F A SAM G H MASSIOT G | 2002 | Fitoterapia2002，71，： | 1 |
| 10 | Identification of two lipid binding proteins from liver of Gallus domesticus显示文摘 | SAMS G H HARGIS B M HARGIS P S | 1991 | Comp Biochem Physiol B1991，99，1： | 1 |
| 11 | Neighbourhood copmonents analysis显示文摘 | Jacob G Sam R Geoff H | 2004 | Advances in Neural Information Processing Systems2004，17，： | 1 |
| 12 | Simulating carbon dioxide sequestration/ECBM production in coal seams:effects of permeability anisotropies and the diffusion-time constant显示文摘 | SMITH D H BROMHAL G SAMS W N | 2005 | SPE Reservoir Evaluation and Engineering2005，8，2： | 1 |
| 13 | Reference crop evapotranspiration from temperature显示文摘 | HARGREAVES G H SAM/NA Z A | 1985 | Applied Engineering in Agriculture1985，，1： | 1 |
| 14 | Gene encoding polygalacturonase inhibitor in apple fruit is developmentally regulated and activated by wounding and fungal infection显示文摘 | YAO C L CONWAY W S REN R H SMITHI D ROSS G S SAMS C E | 1999 | Plant Molecular Biology1999，39，： | 1 |
| 15 | Synthesis of nanocrystalline materials - an overview 显示文摘 | Sam Froes F H Senkov O N Baburaj E G | 2001 | Materials Science and Engineering2001，，301： | 1 |
| 16 | Antifuse field programmable gate arrays显示文摘 | Jonathon G Esmat H Sam B | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员