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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates显示文摘High-fat diets affect male reproduction and sexual function.Therefore,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria diet.Male Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)groups.At 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 months.Animals were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further analysis.Data were analyzed by one-way ANOVA,and P<0.05 was considered statistically significant.The CAF diet promoted hyperglycemia(P<0.0001),and treatment with resveratrol reversed this condition(P<0.0001).The CAF diet reduced sperm viability and motility,while resveratrol improved these parameters(F<0.05).Regarding testicular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).Spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C group.However,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis. | Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio Bianca M Gregorio | 2019 | Asian Journal of Andrology2019，21，2： | 2 |
| 3 | Pulmonary involvement in ankylosing spondylitis显示文摘 | SAMPAIO - BARROS P D CERQUEIRA E M REZENDE S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 4 | An alternative methodology to repair localized corrosion damage in metallic pipelines with epoxy resins 显示文摘 | da Costa-Mattos H S Reis J M L Sampaio R F | 2009 | Materials & Design2009，30，9： | 1 |
| 5 | Prox- imal type I endoleak after endovaseular abdominal aortic aneurysm repair: predictive faetors 显示文摘 | SAMPAIO S M PANNETON J M MOZES G I | 2004 | Annals of Vascular Surgery2004，18，6： | 1 |
| 6 | Pulmonary involement in ankylosing spondylitis 显示文摘 | Sampaio P D Cerqueira E M Rezende S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 7 | Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses显示文摘 | Carvalhinho S Costa A M Coelho A C Martins E Sampaio A | 2012 | Mycopathologia2012，174，： | 1 |
| 8 | Contribution of crotoxin for the inhibitory effect of Crotalus durissus terrifi- cus snake venom on macrophage function显示文摘 | Sampaio S C Brigatte P Sousa e Silva M C | 2003 | Toxicon2003，41，7： | 1 |
| 9 | Growth curves for Macro- brachium rosenbergii in semi - intensive culture in Brazil 显示文摘 | Sampaio C M S Valenti W C | 1996 | J World Aquacult Soc1996，27，3： | 1 |
| 10 | Mode-mismatched thermal lens spectrometry for thermo-optical properties measurement in optical glasses:a review显示文摘 | Lima S M Sampaio J Catunda T | 2000 | J Non-Cryst Solids2000，273，13： | 1 |
| 11 | Biodegradation of the diazo dye Reactive Black 5 by a wild isolate of Candida oleophila显示文摘 | Lucas M S Amaral C Sampaio A | 2006 | Enzyme and Microbial Technology2006，，39： | 1 |
| 12 | Analysis of the thermal decomposition of commercial vegetable oils in air by simultaneous tg/dta显示文摘 | DWECK J SAMPAIO C M S | 2004 | Journal of thermal analysis and calorimetry2004，75，2： | 1 |
| 13 | Adsorp- tion of carotenes and phosphorus from palm oil onto acid ac- tivated bleaching earth: equilibrium, kinetics and thermo- dynamics 显示文摘 | SILVA S M SAMPAIO K A CERIANI R | 2013 | JFoodEng2013，118，4： | 1 |
| 14 | Degradation of a textile reactive azo dye by a combined chemicalebiological process: Fenton's reagent-yeast显示文摘 | LUCAS M S DIAS A A SAMPAIO A | 2007 | Water Research2007，41，： | 1 |
| 15 | Tailoring coercivity in an array of glass-coated microwires 显示文摘 | SINNECKER E H C P MENEZES F S SAMPAIO L C KNOBEL M VAZQUEZ M | 2001 | J Magn Magn Mater2001，，2： | 1 |
| 16 | Effects of salinity on Brazilian flounder Paralichthy orbignyanns from fertilization to juvenile settlement显示文摘 | SAMPAIO L A FREITAS L S OKAMOTO M H | 2007 | Aquaculture2007，262，234： | 1 |
| 17 | Biodegradation of the diazo dye Reactive Black 5 by a wild isolate of Candida oleophila显示文摘 | LUCAS M S AMARAL C SAMPAIO A | 2006 | Enzyme and Microbial Technology2006，39，： | 1 |
| 18 | Activatedcarbons treated with sulphuric acid: Catalysts forcatalytic wet peroxide oxidation 显示文摘 | Gomes H T Miranda S M Sampaio M J | 2010 | Catal Today2010，151，1： | 1 |
| 19 | Pulmonary involement in ankylosing spondylitis 显示文摘 | Sampaio P D Cerqueira E M Rezende S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 20 | Increased growth hormone (GH), growth hormone receptor (GHR), and insulin-like growth factor I (IGF-I) gene transcription after hyperosmotic stress in the Brazilian flounder Paralichthys orbignyanus显示文摘 | Karina M. Meier Márcio A. Figueiredo Michel T. Kamimura Jomar Laurino Rodrigo Maggioni Luciano S. Pinto Odir A. Dellagostin Marcelo B. Tesser Luís A. Sampaio Luis F. Marins | 2009 | Fish Physiology and Biochemistry2009，，3： | 1 |
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