|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Supercritical water oxidation process under energetically self-sufficient operation 显示文摘 | Cocero M J Alonso E Sanz M T | 2002 | Journal of Supercritical Fluids2002，24，1： | 2 |
| 3 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 4 | Pulmonary arterial hyperten- sion: noninvasive detection with phase-contrast MR irnaging显示文摘 | Sanz J Kuschnir P Rius T | 2007 | Radiology2007，243，1： | 1 |
| 5 | Effect of breed on the muscle glycogen content and dark cutting incidence in stressed young bulls显示文摘 | SANZ M C VERDE M T SAEZ T | 1996 | Meat Science1996，43，1： | 1 |
| 6 | Hydroperoxide lyase depletion in transgenic potato plants leads to an increase in aphid performance显示文摘 | VANCANNEYT G SANZ C FARMAKI T | 2001 | Proc Nad Acad Sci USA2001，98，14： | 1 |
| 7 | Influence of ingredients on the thermo-rheological behaviour of batters containing methyl- cellulose显示文摘 | Sanz T Salvador A Vlez G | 2005 | Food Hydrocolloids2005，19，5： | 1 |
| 8 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Sofia M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，840，： | 1 |
| 9 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 10 | Super- critical water oxidation process under energetically self sufficient operation显示文摘 | COCERO M J ALONSO E SANZ M T | 2002 | Supercritical Fluids2002，24，1： | 1 |
| 11 | Determination of omeprazole,hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography显示文摘 | PEREZ-RUIZ T MARTINEZ-LOZANO C SANZ A | 2006 | J Pharm Biomed Anal2006，42，1： | 1 |
| 12 | The role of the clinical research coordinator - data manager - in oncology clinical trials显示文摘 | Rico-Villademoros F Hernando T Sanz JL | 2004 | BMC Med Res Methodol2004，3，25： | 1 |
| 13 | Nitrogen stimulated in- creases in peach yield are associated with extended fruit devel- opment period and increased fruit sink capacity显示文摘 | Sanz J L Dejong T M Weinbaun S A | 1997 | Journal of the American Society for Horticultural Science1997，122，6： | 1 |
| 14 | Production and concentration of monoacylglycerols rich in omega - 3 polyun- saturated fatty acids by enzymatic glycerolysis and molecular distillation显示文摘 | Solaesa A G Sanz M T Falkeborg M | 2016 | Food Chemistry2016，190，： | 1 |
| 15 | Sensory improvement of dry-fermented sausages by the addition of cell-free extracts from Debaryomices hansenii and Lactobacillus sakei显示文摘 | BOLUMAR T SANZ Y ARISTOY M C | 2006 | Meat Science2006，，72： | 1 |
| 16 | Molecular biology techniques used in wastewater treatment: an overview显示文摘 | Sanz JL Kochling T | 2007 | Process Biochemistry2007，42，2： | 1 |
| 17 | Drug delivery to the inner ear:strategies and their therapeutic implications for sensorineural hearing loss显示文摘 | RIVERA T SANZ L CAMARERO G | 2012 | Curr Drug Deliv2012，9，： | 1 |
| 18 | Release, partitioning and stability of isoflavones from enriched custards during mouth, stomach and intestine in vitro simulations显示文摘 | SANZ T LUYTEN H | 2006 | Food Hydrocolloids2006，20，： | 1 |
| 19 | The role of the clinical research coordinator-data manager-in oncology clinical trials显示文摘 | Rico-Villademoros F Hernando T Sanz JL Lopez-Alonso A Salamanca O Camps C | 2004 | BMC Med Res Methodol2004，4，： | 1 |
| 20 | The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin显示文摘 | NAGANO T MITCHELL J A SANZ L A | 2008 | Science2008，322，5908： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员