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| 1 | Epigenetic changes associated with oocyte aging显示文摘It is well established that the decline in female reproductive outcomes is related to postovulatory aging of oocytes and advanced maternal age.Poor oocyte quality is correlated with compromised genetic integrity and epigenetic changes during the oocyte aging process.Here,we review the epigenetic alterations,mainly focused on DNA methylation,histone acetylation and methylation associated with postovulatory oocyte aging as well as advanced maternal age.Furthermore,we address the underlying epigenetic mechanisms that contribute to the decline in oocyte quality during oocyte aging. | SCHATTEN Heide MA JunYu SCHATTEN Heide SUN QingYuan | 2012 | Science China(Life Sciences)2012，55，8： | 16 |
| 2 | Sperm Mitochondria in Reproduction:Good or Bad and Where Do They Go?显示文摘The mitochondrion is the major energy provider to power sperm motility.In mammals,aside from the nuclear genome,mitochondrial DNA(mtDNA) also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides.However,the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial.The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted.However,this may be not true for several mammalian species,including mice and humans.Here,we review the sperm mitochondria and their mtDNA in sperm functions,and the mechanisms of maternal mitochondrial inheritance in mammals. | Shi-Ming Luo Heide Schatten Qing-Yuan Sun | 2013 | Journal of Genetics and Genomics2013，40，11： | 8 |
| 3 | Mitochondrial distribution and microtubule organization in fertilized and cloned porcine embryos: Implications for developmental potential显示文摘 | Mika Katayama Zhisheng Zhong Liangxue Lai Peter Sutovsky Randall S. Prather Heide Schatten | 2006 | Developmental Biology2006，，1： | 1 |
| 4 | The impact of mitochondrial function/dysfunc- tion on IVF and new treatment possibilities for in- fertility 显示文摘 | Heide Schatten Qing- Yuan Sun Randall Prath- er | 2014 | Reproductive Biology and Endocrinol- ogy2014，，12： | 1 |
| 5 | Molecules and mechanisms controlling the active DNA demethylation of the mammalian zygotic genome显示文摘在早胚胎的活跃 DNA demethylation 为随后的开发是必要的。尽管 zygotic 染色体是,全球性, demethylated,印的区域的 DNA methylation,重复序列的部分和一些配偶子特定的区域被维持。最近的证据证明了多重蛋白质和生物小径参予活跃 DNA demethylation 的规定,例如 TET 蛋白质, DNA 修理小径和 DNA methyltransferases。这里,我们关于与活跃 DNA demethylation 和在早胚胎控制活跃 DNA demethylation 的规章的网络联系的蛋白质考察最近的理解。 | Jun-Yu Ma Teng Zhang Wei Shen Heide Schatten Qing Yuan Sun | 2014 | Protein & Cell2014，5，11： | 1 |
| 6 | 生物型低压扫描电子显微镜显示文摘扫描电子显微镜于20世纪60年代问世,用来观察标本的表面结构。其工作原理是用一束极细的电子束扫描样品,在样品表面激发出次级电子,次级电子的多少与电子束入射角有关,也就是说与样品的表面结构有关,次级电子由探测体收集,并在那里被闪烁器转变为光信号,再经光电倍增管和放大器转变为电信号来控制荧光屏上电子束的强度,显示出与电子束同步的扫描图像。图像为立体形象,反映了标本的表面结构。 | Heide Schatten 程恩隽 | 2008 | 国外科技新书评介2008，，9： | 0 |
| 7 | Environmentally Induced Paternal Epigenetic Inheritance and Its Effects on Offspring Health显示文摘Increasing evidences indicate that chronic diseases in offspring may be the result of ancestral environmental exposures. Exposures to environmental compounds in windows of epigenetic susceptibility have been shown to promote epigenetic alterations that can be inherited between generations. DNA methylation, histone modifications, and noncoding RNAs are sound mechanistic candidates for the delivery of environmental information from gametes to zygotes. This review focuses mainly on paternal exposures and assesses the risk of epigenetic alterations in the development of diseases, providing insights into relationships between aberrant sperm epigenetic patterns and offspring health. Elucidation of the mechanisms underlying environmental epigenetic information that survive from epigenetic reprogramming and its transmission to future generations may hold a great promise for providing therapeutic targets for epigenetic diseases associated with environmental exposures. | Zhao Zheng-Hui Schatten Heide Sun Qing-Yuan | 2017 | Reproductive and Developmental Medicine2017，1，2： | 0 |
| 8 | New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout显示文摘In comparison to conventional knockout technology and in vitro research methods,conditional gene knockout has remarkable advantages.In the past decade,especially during the past five years,conditional knockout approaches have been used to study the regulation of foUiculogenesis,follicle growth,oocyte maturation and other major reproductive events.In this review,we summarize the recent findings about folliculogenesis/oogenesis regulation,including the functions of four signaling cascades or glycoprotein domains that have been extensively studied by conditional gene deletion.Several other still fragmented areas of related work are introduced which are awaiting clarification.We have also discussed the future potential of this technology in clarifying gene functions in reproductive biology. | Meng-Wen Hu Zhen-Bo Wang Heide Schatten Qing-Yuan Sun | 2012 | Journal of Genetics and Genomics2012，39，2： | 0 |
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