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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Biometric and ICL-related risk factors associated to sub-optimal vaults in eyes implanted with implantable collamer lenses显示文摘Background:To identify biometric and implantable collamer lens(ICL)-related risk factors associated with suboptimal postoperative vault in eyes implanted with phakic ICL.Methods:This study reports a retrospective case series of the first operated eye in 360 patients implanted with myopic spherical or toric ICL.Preoperatively,white-to-white(WTW),central keratometry(Kc)and central corneal thickness(CCT)were measured using the Pentacam.Anterior-segment optical coherence tomography(AS-OCT,Visante)was applied preoperatively for measuring the horizontal anterior-chamber angle-to-angle distance(ATA),internal anterior chamber depth(ACD),crystalline lens rise(CLR),anterior-chamber angle(ACA)and postoperatively the vault.Eyes were divided into three vault groups:low(LVG:≤250μm),optimal(OVG:>250 and<1000μm)and high(HVG:≥1000μm).Multinomial logistic regression(MLR)was used to find the sub-optimal vault predictors.Results:MLR showed that CLR,ICL size minus the ATA(ICL size-ATA),age,ICL spherical equivalent(ICLSE)and ICL size as contributing factors for sub-optimal vaults(pseudo-R2=0.40).Increased CLR(OR:1.01,CI:1.00-1.01)and less myopic ICLSE(OR:1.22,CI:1.07-1.40)were risk factors for low vaults.Larger ICL size-ATA(OR:41.29,CI:10.57-161.22)and the 13.7mm ICL(OR:7.08,CI:3.16-15.89)were risk factors for high vaults,whereas less myopic ICLSE(OR:0.85,CI:0.76-0.95)and older age(OR:0.92,CI:0.88-0.98)were protective factors.Conclusion:High CLR and low ICLSE were the major risk factors in eyes presenting low vaults.In the opposite direction,ICL size-ATA was the major contributor for high vaults.This relationship was more critical in higher myopic ICLSE,younger eyes and when 13.7mm ICL were used.The findings show that factors influencing the vault have differentiated weight of influence depending on the type of vault(low,optimal or high). | Santiago Cerpa Manito Angel Sánchez Trancón Oscar Torrado Sierra António Manuel Baptista Pedro Miguel Serra | 2021 | Eye and Vision2021，8，1： | 5 |
| 3 | Atomistic study of diffusional mass transport in metals显示文摘 | OSETSKY Y N BACON D J SERRA A | | 0，，1： | 1 |
| 4 | Telomere length as a marker of oxidative stress in primary human fibroblast cultures显示文摘 | Serra V Grune T Sitte N | 2000 | Ann NY Acad Sci2000，908，： | 1 |
| 5 | Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors显示文摘 | Ranelletti F O Maggiano N Serra F G | 2000 | Int J Cancer2000，85，3： | 1 |
| 6 | Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectahumors显示文摘 | Ranelletti FO Maggiano N Serra FG | 2000 | Int J Cancer2000，85，3： | 1 |
| 7 | Laparoscopic sleeve gastrectomy: a multi-purpose operation 显示文摘 | Baltasar A Serra C Perez N | 2005 | Obes Surg2005，15，： | 1 |
| 8 | Suppression of LPS-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite, 5- (phydroxyphenyl-O, 5 -phenylhydantoin显示文摘 | Serra R Al-Saidi AG Angelov N | 2010 | J Inflamm (Lond)2010，7，： | 1 |
| 9 | Evaluation of paraffins biodegradation and biosurfactant production by Bacillus subtilis in the presence of crude oil显示文摘 | Carmen L Q Lidia R N Gil Eduardo Serra | 2003 | Brazilian Journal of Microbiology2003，34，4： | 1 |
| 10 | Shape optimi- zation of quasi-brittle asymmetric shells by genetic al- gorithm 显示文摘 | Banichuk N V Serra M Sinitsyn A | 2006 | Computers and Structures2006，84，2930： | 1 |
| 11 | Laparoscopie reoperative sleeve gastrectomy 显示文摘 | Serra C Baltasar A Perez N | 2007 | Cir Esp2007，82，1： | 1 |
| 12 | Laparoscopic sleeve gastrectomy: a multipurpose bariatric operation 显示文摘 | Baltasar A Serra C Perez N | 2005 | Obes Surg2005，15，8： | 1 |
| 13 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 14 | Benign partial epilepsy in childhood:selective cognitive deficits are related to the location of focal spikes determined by combined EEG/MEG显示文摘 | Wolff M Weiskopf N Serra E | 2005 | Epilepsia2005，46，10： | 1 |
| 15 | Quercetin inhibits p21-RAS expression in humn colon cancer cell lines and in primary colorectal tumors显示文摘 | MAGGIANO N SERRA FG | 2000 | Int J Cancer2000，85，3： | 1 |
| 16 | Laparoscopic sleeve gastrectomy:a multipurpose bariatric operation显示文摘 | Baltasar A Serra C Pérez N | 2005 | Obes Surg2005，15，8： | 1 |
| 17 | In vitro bioactivity of laser ablation pseudowollastonite coating显示文摘 | De Aza P N Fernandez-Pradas J M Serra P | 2004 | Biomaterials2004，25，11： | 1 |
| 18 | Querdetin inhibits p21- RAS expression in human colon cancer cell lines and in primary colorectal tumors显示文摘 | R anelletti FO Maggiano N Serra FG | 2000 | Int J Cancer2000，85，： | 1 |
| 19 | Angiotensin-converting enzyme inhibition by Brazilian plants 显示文摘 | Braga F C Serra C P Viana Junior N S | 2007 | Fitoterapia2007，78，5： | 1 |
| 20 | Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors显示文摘 | Ranelletti FO Maggiano N Serra FG | 2000 | Int J Cancer2000，85，3： | 1 |
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