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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Evaluation of Chlorophyll Content and Fluorescence Parameters as Indicators of Drought Tolerance in Barley显示文摘Drought is a major abiotic stress that severely affects food production worldwide. Agronomic and physiological traits associated with drought tolerance are suitable indicators for selection of drought tolerance genotypes to reduce the impact of water deficit on crop yield in breeding program. The objective of this study was to identify indicators related to drought tolerance through analysis of photosynthetic traits in barley (Hordeum vulgare L.). These traits included chlorophyll content, initial fluorescence (Fo), maximum primary yield of photochemistry of photosystem Ⅱ (Fv / Fo) and maximum quantum yield of photosystem II (Fv / Fm). Four genotypes (Tadmor, Arta, Morocco9-75 and WI2291) variable in drought tolerance were used to investigate the correlation between these traits and drought tolerance. The results reflected that all of these traits were affected negatively in the four genotypes at different levels of post-anthesis drought stress, but the decrease in drought tolerant genotypes was much less than that of drought sensitive genotypes. The results further revealed that the components of the photosynthetic apparatus could be damaged significantly in drought sensitive genotypes, while drought tolerant genotypes were relatively less affected. On the other hand, the values of chlorophyll content, Fo, Fv / Fo and Fv / Fm in drought tolerance genotypes were significantly higher than those in drought sensitive genotypes under drought stress. It was concluded that chlorophyll content, Fo, Fv / Fo and Fv / Fm could be considered as reliable indicators in screening barley germplasm for drought tolerance. | LI Rong-hua GUO Pei-guo Michael Baum Stefania Grando Salvatore Ceccarelli | 2006 | Agricultural Sciences in China2006，5，10： | 51 |
| 3 | Editorial statement显示文摘In the following four articles,we will provide an overview of the current clinical work in different areas of liver transplantation.For many decades,this transplantation has been the treatment choice for patients suffering from chronic | Salvatore Gruttadauria Bruno G Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 43 |
| 4 | Worldwide epidemiology of liver hydatidosis including the Mediterranean area显示文摘The worldwide incidence and prevalence of cystic echinococcosis have fallen dramatically over the past several decades.Nonetheless,infection with Echinococcus granulosus(E.granulosus)remains a major public health issue in several countries and regions,even in places where it was previously at low levels,as a result of a reduction of control programmes due to economic problems and lack of resources.Geographic distribution differs by country and region depending on the presence in that country of large numbers of nomadic or semi-nomadic sheep and goat flocks that represent the intermediate host of the parasite,and their close contact with the final host,the dog,which mostly provides the transmission of infection to humans.The greatest prevalence of cystic echinococcosis in human and animal hosts is found in countries of the temperate zones,including several parts of Eurasia(the Mediterranean regions,southern and central parts of Russia,central Asia,China),Australia,some parts of America(especially South America)and north and east Africa.Echinococcosis is currently considered an endemic zoonotic disease in the Mediterranean region.The most frequent strain associated with human cystic echinococcosis appears to be the common sheep strain(G1).This strain appears to be widely distributed in all continents.The purpose of this review is to examine the distribution of E.granulosus and the epidemiology of a re-emerging disease such as cystic echinococcosis. | Giuseppe Grosso Salvatore Gruttadauria Antonio Biondi Stefano Marventano Antonio Mistretta | 2012 | World Journal of Gastroenterology2012，18，13： | 36 |
| 5 | Follow-up of intestinal metaplasia in the stomach: When, how and why显示文摘Gastric cancer remains the second most frequent cause of cancer-related mortality in the world. Screening programs in some Asian countries are impractical in the majority of other countries worldwide. Therefore, follow-up of precancerous lesions is advisable for secondary gastric cancer prevention. Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is highly prevalent in the general population, being detected in nearly 1 of every 4 patients undergoing upper endoscopy. The IM prevalence rate is significantly higher in patients with Helicobacter pylori (H. pylori) infection, in first-degree relatives of gastric cancer patients, in smokers and it increases with patient age. IM is the 'breaking point' in the gastric carcinogenesis cascade and does not appear to regress following H. pylori eradication, although the cure of infection may slow its progression. Gastric cancer risk is higher in patients with incomplete-type IM, in those with both antral and gastric body involvement, and the risk significantly increases with IM extension over 20% of the gastric mucosa. Scheduled endoscopic control could be cost-effective in IM patients, depending on the yearly incidence of gastric cancer in IM patients, the stage of gastric cancer at diagnosis discovered at surveillance, and the cost of endoscopy. As a pragmatic behavior, yearly endoscopic control would appear justified in all IM patients with at least one of these conditions: (1) IM extension > 20%; (2) the presence of incomplete type IM; (3) first-degree relative of gastric cancer patients; and (4) smokers. In the remaining IM patients, a less intensive (2-3 years) could be proposed. | Angelo Zullo Cesare Hassan Adriana Romiti Michela Giusto Carmine Guerriero Roberto Lorenzetti Salvatore MA Campo Silverio Tomao | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 25 |
| 6 | Blue carbon on the rise:challenges and opportunities显示文摘BLUE CARBON ON THE RISE Climate change is a global concem that requires urgent solutions.As a signatory to the Paris Agreement,China has committed to have its greenhouse gas emission reach a peak by the year 2030,which means that severe countermeasures for reducing emissions have to be put into practice.This is a hard mission given that development is still the top priority in the years to come for China.Under such circumstances,enhancing carbon sequestration becomes an effective approach to achieving the goal.While terrestrial green carbon sink is already in practice,the ocean carbon reservoir,containing 93%of global CO2,as 50 and 20 times the carbon inventories of atmosphere and land,respectively,has great potential to expand.Each year,at least 25% of the anthropogenic CO2 has been captured by marine ecosystems as blue carbon [1]. | Nianzhi Jiao Hong Wang Guanhua Xu Salvatore Aricò | 2018 | National Science Review2018，5，4： | 25 |
| 7 | Clinical applications of hepatocyte transplantation显示文摘The shortage of organ donors is a problem worldwide, with approximately 15% of adult patients with lifethreatening liver diseases dying while on the waiting list. The use of cell transplantation for liver disease is an attempt to correct metabolic defects, or to support liver function as a bridge to liver transplantation and, as such, has raised a number of expectations. Most of the available studies briefly reported here focus on adult hepatocyte transplantation (HT), and the results are neither reproducible nor comparable, because the means of infusion, amount of injected cells and clinical variability differ among the studies. To better understand the specif ic role of HT in the management of end-stage liver disease, it is important that controlled studies, designed on the principles of evidence-based medicine, be done in order to guarantee the reproducibility of results. | Giada Pietrosi Giovanni Battista Vizzini Salvatore Gruttadauria Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，17： | 23 |
| 8 | Histopathology of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence worldwide.Its etiology is usually linked to environmental,dietary or lifestyle factors.HCC most commonly arises in a cirrhotic liver but interestingly an increasing proportion of HCCs develop in the non-fibrotic or minimal fibrotic liver and a shift in the underlying etiology can be observed.Although this process is yet to be completely understood,this changing scenario also has impact on the material seen by pathologists,presenting them with new diagnostic dilemmas.Histopathologic criteria for diagnosing classical,progressed HCC are well established and known,but with an increase in detection of small and early HCCs due to routine screening programs,the diagnosis of these small lesions in core needle biopsies poses a difficult challenge.These lesions can be far more difficult to distinguish from one another than progressed HCC,which is usually a clear cut hematoxylin and eosin diagnosis.Furthermore lesions thought to derive from progenitor cells have recently been reclassified in the WHO.This review summarizes recent developments and tries to put new HCC biomarkers in context with the WHOs reclassification.Furthermore it also addresses the group of tumors known as combined hepatocellular-cholangiocellular carcinomas. | Manuel Schlageter Luigi Maria Terracciano Salvatore D'Angelo Paolo Sorrentino | 2014 | World Journal of Gastroenterology2014，20，43： | 20 |
| 9 | 在直肠的癌症的磁性的回声成像调查结果的临床的意义显示文摘 Staging of rectal cancer is essential to help guide clini-cians to decide upon the correct type of surgery and determine whether or not neoadjuvant therapy is indicated. Magnetic resonance imaging (MRI) is currently one of the most accurate modalities on which to base treatment decisions for patients with rectal cancer. MRI can accurately detect the mesorectal fascia, assess the invasion of the mesorectum or surrounding organs and predict the circumferential resection margin. Although nodal disease remains a difficult radiological diagnosis, new lymphographic agents and diffusion weighted imaging may allow identification of metastatic nodes by criteria other then size. In light of this, we have reviewed the literature on the accuracy of specific MRI findings for staging the local extent of primary rectal cancer. The aim of this review is to establish a correlation between MRI findings, prognosis, and available treatment options. | Charles F Bellows Bernard Jaffe Lorenzo Bacigalupo Salvatore Pucciarelli Guiseppe Gagliardi | 2011 | World Journal of Radiology2011，3，4： | 19 |
| 10 | 108例创伤性动静脉瘘的介入诊疗分析显示文摘目的分析创伤性动静脉瘘(AVF)的临床特点、造影表现、造影技术及治疗方式的选择。方法回顾性分析纽约Kings County医疗中心25年间全部确诊的108例创伤性AVF的介入相关诊疗资料。分析内容包括患者外伤种类、临床表现、损伤部位、血管造影异常特征、AVF血流动力学特征(分5个类型)、治疗方式的选择等。结果 108例患者中共发现117处AVF,大多数患者临床特征不明确。创伤种类包括枪伤(导致72处AVF)、刺伤(24处)、钝性伤(8处)、高处坠落伤(3处)、医源性损伤(2处)。损伤部位常见于肢体(46例)、颈部(19例)、肝脏(13例)和锁骨下血管(11例)。所有病变均可见静脉早显,显示动脉横断52处,撕裂37处,49.6%的AVF与假性动脉瘤有关。最常见的血流特点是Ⅰ型,即瘘口所在的动脉近段和远段、静脉的近段和远段都显示,伴远侧段静脉瓣功能不全,共40处瘘(34.2%),其次是Ⅲ型22个(18.8%),Ⅴ型最不常见(4.3%)。34例接受手术治疗,61例栓塞治疗,7例临床观察。分别采用弹簧圈(47例)、明胶海绵(9例)、无水乙醇(3例)、可脱球囊(2例),其中弹簧圈效果理想、并发症少。6例采用覆膜支架效果好。结论血管造影是诊断创伤性AVF的金标准,造影时准确观察动脉损伤的性质,瘘口的解剖和血流特点及所有进入瘘口的动脉分支,对于选择治疗方式及保证介入治疗的成功完成至关重要。 | 王晓东 Salvatore JA Sclafani | 2010 | 介入放射学杂志2010，19，7： | 16 |
| 11 | Small-for-size syndrome in adult-to-adult living-related liver transplantation显示文摘Small-for-size syndrome (SFSS) in adult-to-adult living-related donor liver transplantation (LRLT) remains the greatest limiting factor for the expansion of segmental liver transplantation from either cadaveric or living donors. Portal hyperperfusion, venous pathology, and the arterial buffer response signif icantly contribute to clinical and histopathological manifestations of SFSS. Here, we review the technical aspects of surgical and radiological procedures developed to treat SFSS in LRLT, along with the pathophysiology of this condition. | Salvatore Gruttadauria Duilio Pagano Angelo Luca Bruno Gridelli | 2010 | World Journal of Gastroenterology2010，16，40： | 15 |
| 12 | Genetic background in nonalcoholic fatty liver disease: A comprehensive review显示文摘In the Western world, nonalcoholic fatty liver disease(NAFLD) is considered as one of the most significant liver diseases of the twenty-first century. Its development is certainly driven by environmental factors, but it is also regulated by genetic background. The role of heritability has been widely demonstratedby several epidemiological, familial, and twin studies and case series, and likely reflects the wide interindividual and inter-ethnic genetic variability in systemic metabolism and wound healing response processes. Consistent with this idea, genome-wide association studies have clearly identified Patatin-like phosholipase domain-containing 3 gene variant I148 M as a major player in the development and progression of NAFLD. More recently, the transmembrane 6 superfamily member 2 E167 K variant emerged as a relevant contributor in both NAFLD pathogenesis and cardiovascular outcomes. Furthermore, numerous casecontrol studies have been performed to elucidate the potential role of candidate genes in the pathogenesis and progression of fatty liver, although findings are sometimes contradictory. Accordingly, we performed a comprehensive literature search and review on the role of genetics in NAFLD. We emphasize the strengths and weaknesses of the available literature and outline the putative role of each genetic variant in influencing susceptibility and/or progression of the disease. | Fabio Salvatore Macaluso Marcello Maida Salvatore Petta | 2015 | World Journal of Gastroenterology2015，21，39： | 14 |
| 13 | On a unique behavior of freshwater bacteria显示文摘Magnetic sensitivity has been found in bacteria from freshwater sites around Pavia, Italy. | Salvatore BELLINI | 2009 | Chinese Journal of Oceanology and Limnology2009，27，1： | 13 |
| 14 | Hepatocellular adenoma: An unsolved diagnostic enigma显示文摘Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA,β-catenin-mutated HCA, and unclassified HCA.β-cateninmutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization. | Matteo Renzulli Alfredo Clemente Francesco Tovoli Salvatore Cappabianca Luigi Bolondi Rita Golfieri | 2019 | World Journal of Gastroenterology2019，25，20： | 12 |
| 15 | Hepatitis B vaccine by intradermal route in non responder patients:An update显示文摘Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus(HBV)infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90%of general population.Individuals who develop an antiHBs titer less than 10 mIU/mL after primary vaccination cycle are defined'no responders'.Many factors could cause a non response to the HBV vaccination,such as administration of the vaccine in buttocks,impaired vaccine storage conditions,drug abuse,smoking,infections and obesity.Moreover there are some diseases,like chronic kidney disease,human immunodeficiency virus infection,chronic liver disease,celiac disease,thalassaemia,typeⅠdiabetes mellitus,down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects.To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection.Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route.This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients.A comprehensive review of the literature using PubMed database,with appropriate terms,was undertaken for articles in English published since 1983.The literature search was undertaken in September 2013. | Martina Filippelli Elena Lionetti Alessia Gennaro Angela Lanzafame Teresa Arrigo Carmelo Salpietro Mario La Rosa Salvatore Leonardi | 2014 | World Journal of Gastroenterology2014，20，30： | 12 |
| 16 | Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology显示文摘There are many causes of gastrointestinal bleeding(GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality. To assist medical care providers in the evaluation and management of children with GIB, the 'Gastro-Ped Bleed Team' of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition(SIGENP) carried out a systematic search on MEDLINE via Pub Med(http://gffzz16a62c593b5540cehqw9fvf6xcc606k06.ffgz.tsg.suse.edu.cn/pubmed/) to identify all articles published in English from January 1990 to 2016; the following key words were used to conduct the electronic search: 'upper GIB' and 'pediatric' [all fields]; 'lower GIB' and 'pediatric' [all fields]; 'obscure GIB' and 'pediatric' [all fields]; 'GIB' and 'endoscopy' [all fields]; 'GIB' and 'therapy' [all fields]. The identified publications included articles describing randomized controlled trials, reviews, case reports, cohort studies, casecontrol studies and observational studies. References from the pertinent articles were also reviewed. This paper expresses a position statement of SIGENP that can have an immediate impact on clinical practice and for which sufficient evidence is not available in literature. The experts participating in this effort were selected according to their expertise and professional qualifications. | Claudio Romano Salvatore Oliva Stefano Martellossi Erasmo Miele Serena Arrigo Maria Giovanna Graziani Sabrina Cardile Federica Gaiani Gian Luigi de'Angelis Filippo Torroni | 2017 | World Journal of Gastroenterology2017，23，8： | 12 |
| 17 | Interventional radiology procedures in adult patients who underwent liver transplantation显示文摘Interventional radiology has acquired a key role in every liver transplantation(LT)program by treating the majority of vascular and non-vascular post-transplant complications,improving graft and patient survival and avoiding,in the majority of cases,surgical revision and/or re-transplantation.The aim of this paper is to review indications,technical consideration,results achievable and potential complications of interventional radiology procedures after deceased donor LT and living related adult LT. | Roberto Miraglia Luigi Maruzzelli Settimo Caruso Mariapina Milazzo Gianluca Marrone Giuseppe Mamone Vincenzo Carollo Salvatore Gruttadauria Angelo Luca Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 18 | Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer显示文摘Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives. | Gianlorenzo Dionigi Luigi Boni Francesca Rovera Stefano Rausei Salvatore Cuffari Giovanni Cantone Alessandro Bacuzzi Renzo Dionigi | 2009 | World Journal of Gastroenterology2009，15，32： | 10 |
| 19 | Atherosclerosis,inflammation and Chlamydia pneumoniae显示文摘Coronary heart disease is the single most common cause of illness and death in the developed world.Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease,and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina,myocardial infarction,and sudden death.Atherosclerosis is the result of a complex interaction between blood elements,disturbed flow,and vessel wall abnormality,involving several pathological processes:inflammation,with increased endothelial permeability,endothelial activation,and monocyte recruitment;growth,with smooth muscle cell proliferation,migration,and matrix synthesis;degeneration,with lipid accumulation;necrosis,possibly related to the cytotoxic effect of oxidized lipid;calcification/ossification,which may represent an active rather than a dystrophic process;and thrombosis,with platelet recruitment and fibrin formation.In this review we discuss these processes and the possible pathological effects of Chlamydia infection and the ensuing phlogosis. | Giovanni Fazio Maria Giovino Alessandro Gullotti Daniela Bacarella Giuseppina Novo Salvatore Novo | 2009 | World Journal of Cardiology2009，1，1： | 10 |
| 20 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
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