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| 1 | 精液中硒含量与精子质量和精子DNA氧化损伤的关系显示文摘目的 探讨血清和精液中硒浓度与精子质量和精子DNA氧化损伤的关系。方法 用原子吸收光谱检测血清和精液中硒浓度 ,按WHO规范方法检测精液量、精子数、每次射出精子总数、活力和活动精子百分率及精子畸形率 ,用高压液相色谱 光电检测系统和高压液相色谱 紫外线检测器同时检测人精子DNA 8 羟基脱氧核糖鸟苷 (8 OHdG)和脱氧核糖鸟苷 (dG)水平。结果 已孕组精液硒平均浓度 (0 74μmol/L)明显高于不孕组 (0 5 6 μmol/L) ,而两组间血清硒平均浓度差异无显著性。已孕组精液量、精子数和每次射出精子总数的平均值 (3 91ml、46 4× 10 9/L和 16 8 0× 10 6)明显高于不孕组 (2 79ml、36 5× 10 9/L和 10 2 0× 10 6) ,两组间精子活力、活动精子百分率和精子畸形率的平均值差异无显著性。精液硒浓度与精子数、每次射出精子总数、精子活力、活动精子百分率之间呈明显的正相关 ,而血清硒浓度与精子质量均无明显相关关系。精子DNA 8 OHdG水平与精液硒浓度呈明显负相关 ,而与血清硒浓度无明显相关关系。结论 精液硒浓度与人类精子质量和精子DNA 8 OHdG有关 。 | 徐德祥 Ong Choonnam Shen Hanming Chua Laiha Chia Seneng | 2001 | 中华预防医学杂志2001，35，6： | 16 |
| 2 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 3 | 广西原发性肝细胞癌与p53基因72密码子单核苷酸多态性密切相关显示文摘 | 彭涛 严律南 刘志明 Hanming shen Choon Nam Ong 彭民浩 黎乐群 李家荃 | 2004 | 中华外科杂志2004，42，5： | 3 |
| 4 | 广西肝癌高发区氧化性DNA损伤与修复酶hOGG_1的表达和多态性关系的研究显示文摘目的研究广西肝癌高发区未成年人的氧化性DNA损伤情况。方法采用流式细胞技术检测外周血白细胞DNA7,8-dihydro-8-oxoGuanine(8-oxoG)及其修复酶hOGG1的水平,采用PCR-SSCP技术检测hOGG1-Cys326Ser多态性。结果8-oxoG与hOGG1表达水平高度相关(0·48 | 刘志明 彭涛 严律南 彭民浩 黎乐群 李家荃 梁任祥 韦忠亮 Shen Hanming Ong Choon Nam | 2005 | 中华肝胆外科杂志2005，11，8： | 3 |
| 5 | Dual Laterolog Response in Anisotropic Crossbedding Formation显示文摘 | Hanming W Shen L C | 2001 | Petrophysics2001，42，6： | 1 |
| 6 | Salvia mil tiorrhiza inhibits cell growth and induces apoptosis inhuman hepatoma HepG2 cells显示文摘 | Jin Liu Hanming Shen Choon Nam Ong | 2000 | Cancer Letters2000，153，1： | 1 |
| 7 | Dual laterolog in 3 - D environments 显示文摘 | Wang Hanming Shen Liang C Zhang Geng Ji | 2000 | Petrophysics2000，41，3： | 1 |
| 8 | Risk assessment of nickel earcinogenicity and occupational lung cancer 显示文摘 | Shen Hanming Zhang Qifeng | 1994 | Environmental Health Perspective1994，102，1： | 1 |
| 9 | Salvia Mihiorrhi- za inhibits cell growth and induces Apoptosis in human Hepatoma Hepatoma HepG2 cells显示文摘 | LIU Jin SHEN Hanming ONG CHOON-NAM | 2000 | Canc Lett2000，153，12： | 1 |
| 10 | DNA strand breaks and poly(ADP-ribose) polymerase activation induced by crystalline nickel subsulfide in MRC-5 lung fibmblast cells显示文摘 | ZHUANG Zhixiong SHEN Yi SHEN Hanming | 1996 | Hum Exp Toxicol1996，15，： | 1 |
| 11 | Microcysticcyanobacteria causes mitochondrial memberane potential alteration andreactive oxygen species formation in primary cultured rat hepatocytes显示文摘 | DING Wenxing SHEN Hanming SHEN Yi | 1998 | Environment Heath Prespect1998，106，7： | 1 |
| 12 | Dual Laterolog Response in 3-D Environments显示文摘 | Hanming Wang Liang C Shen and Geng ji Zhang | 2000 | Petrophysics2000，41，： | 1 |
| 13 | Small Molecular NIR-II Fluorophores for Cancer Phototheranostics显示文摘Phototheranostics integrates deep-tissue imaging with phototherapy(containing photothermal therapy and photodynamic therapy),holding great promise in early diagnosis and precision treatment of cancers.Recently,second near-infrared(NIR-II)fluorescence imaging exhibits the merits of high accuracy and specificity,as well as real-time detection.Among the NIR-II fluorophores,organic small molecular fluorophores have shown superior properties in the biocompatibility,variable structure,and tunable emission wavelength than the inorganic NIR-II materials.What’s more,some small molecular fluorophores also display excellent cytotoxicity when illuminated with the NIR laser.This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years,focusing on the molecular structures and phototheranostic performances.Furthermore,challenges and prospects of future development toward clinical translation are discussed. | Hanming Dai Qing Shen Jinjun Shao Wenjun Wang Fan Gao Xiaochen Dong | 2021 | The Innovation2021，2，1： | 0 |
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