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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility显示文摘Porous metal scaffolds play an important role in the orthopedic field, due to their wide applications in prostheses implantation. Some previous studies showed that the scaffolds with trabecular bone structure reconstructed via computed tomography had satisfactory biocompatibility. However, the reverse modeling scaffolds were inflexible for customized design. Therefore, a top-down designing biomimetic bone scaffold with favorable mechanical performances and cytocompatibility is urgently demanded for orthopedic implants. An emerging additive manufacturing technique, selective laser melting, was employed to fabricate the trabecular-like porous Ti-6Al-4 V scaffolds with varying irregularities(0.05-0.5) and porosities(48.83%–74.28%) designed through a novel Voronoi-Tessellation based method. Micro-computed tomography and scanning electron microscopy were used to characterize the scaffolds’ morphology.Quasi-static compression tests were performed to evaluate the scaffolds’ mechanical properties. The MG63 cells culture in vitro experiments, including adhesion, proliferation, and differentiation, were conducted to study the cytocompatibility of scaffolds. Compressive tests of scaffolds revealed an apparent elastic modulus range of 1.93–5.24 GPa and an ultimate strength ranging within 44.9–237.5 MPa, which were influenced by irregularity and porosity, and improved by heat treatment. Furthermore, the in vitro assay suggested that the original surface of the SLM-fabricated scaffolds was favorable for osteoblasts adhesion and migration because of micro scale pores and ravines. The trabecular-like porous scaffolds with full irregularity and higher porosity exhibited enhanced cells proliferation and osteoblast differentiation at earlier time, due to their preferable combination of small and large pores with various shapes. This study suggested that selective laser melting-derived Ti-6Al-4 V scaffold with the trabecular-like porous structure designed through Voronoi-Tessellation method, favorable mechanical performance, and good cytocompatibility was a potential biomaterial for orthopedic implants. | Huixin Liang Youwen Yang Deqiao Xie Lan Li Ning Mao Changjiang Wang Zongjun Tian Qing jiang Lida Shen | 2019 | Journal of Materials Science & Technology2019，35，7： | 12 |
| 3 | Preparation and characterization of nanostructured Al_2O_3-13wt.%TiO_2 ceramic coatings by plasma spraying显示文摘Nanostructured and conventional Al2O3-13wt.%TiO2 ceramic coatings were prepared by plasma spraying with nanostructured agglomerated and conventional powders, respectively. The microstructure and microhardness of the coatings were investigated using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and microhardness measurement. Meanwhile, the friction and wear behaviors were analyzed and compared using a ball-on-disk tribometer. The results show that the conventional coating has lamellar stacking characteristic and has some pores. However, the nanostructured coating shows a bimodal microstructure, which is composed of both fully melted regions and partially melted regions. According to the microstructural difference, the partially melted regions can be divided into liquid-phase sintered regions (a three-dimensional net or skeleton-like structure: Al2O3-rich submicron particles embedded in the TiO2-rich matrix) and solid-phase sintered regions (remained nanoparticles). The microstructural characteristics of the liquid-phase sintered region are formed due to the selective melting of TiO2 nanoparticles during plasma spraying. On the other hand, the TiO2 and Al2O3 nanoparticles of the solid-phase sintered regions are all unmelted during plasma spraying. Due to the existence of nanostructured microstructures, the nanostructured coating has a higher microhardness, a lower friction coefficient, and a better wear resistance than the conventional coating. | WANG Dongsheng TIAN Zongjun SHEN Lida LIU Zhidong HUANG Yinhui | 2009 | Rare Metals2009，28，5： | 4 |
| 4 | A bifunctional bone scaffold combines osteogenesis and antibacterial activity via in situ grown hydroxyapatite and silver nanoparticles显示文摘Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these components.In this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline environment.Next,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering process.Results showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical properties.Simulated body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent bioactivity.In vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia coli.Furthermore,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation. | Youwen Yang Yun Cheng Fang Deng Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai | 2021 | Bio-Design and Manufacturing2021，4，3： | 2 |
| 5 | Building a kinetic model for steam cracking by the method of structure - oriented lumping显示文摘 | Tian Lida Wang Jiming Shen Benxian | 2010 | Energy & fuels2010，24，： | 1 |
| 6 | A Review on Distortion and Residual Stress in Additive Manufacturing显示文摘Additive manufacturing(AM)has gained extensive attention and tremendous research due to its advantages of fabricating complex-shaped parts without the need of casting mold.However,distortion is a known issue for many AM technologies,which decreases the precision of as-built parts.Like fusion welding,the local high-energy input generates residual stresses,which can adversely affect the fatigue performance of AM parts.To the best of the authors’knowledge,a comprehensive review does not exist regarding the distortion and residual stresses dedicated for AM,despite some work has explored the interrelationship between the two.The present review is aimed to fill in the identified knowledge gap,by first describing the evolution of distortion and residual stresses for a range of AM processes,and second assessing their influencing factors.This allows us to elucidate their formation mechanisms from both the micro-and macro-scales.Moreover,approaches which have been successfully adopted to mitigate both the distortion and residual stresses are reviewed.It is anticipated that this review paper opens many opportunities to increase the success rate of AM parts by improving the dimension precision and fatigue life. | Deqiao Xie Fei Lv Youwen Yang Lida Shen Zongjun Tian Cijun Shuai Bo Chen Jianfeng Zhao | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，3： | 1 |
| 7 | Building and application of delayed coking structure - oriented lumping model 显示文摘 | Tian Lida Shen Benxian Liu Jichang | 2012 | Industrial & Engineering Chemistry Research2012，51，10： | 1 |
| 8 | Building a kinetic model for steam cracking by the method of structure - oriented lumping显示文摘 | Tian Lida Wang Jiming Shen Benxian | 2010 | Energy & Fuels2010，24，： | 1 |
| 9 | A delayed eoking rood el built using the structure-oriented lumping method显示文摘 | Tian Lida Shen Benxian Liu Jichang | 2012 | En ergy & Fuels2012，26，3： | 1 |
| 10 | Influences of laser remelting on microstructure of nanostructured A1203-13wt% TiO2 coatings fabricated by plasma spraying 显示文摘 | WANG Dongsheng TIAN Zongjun SHEN Lida | 2009 | Applied Surface Science2009，255，： | 1 |
| 11 | Composition - based modeling for predicting olefin yields of naphtha steam cracking by montecarlomethod显示文摘 | Tian Lida Wang Jiming Shen Benxian | 2011 | Energy Sources Part A : Recovery Utiliza- tion and Environmental Effects2011，39，19： | 1 |
| 12 | Building and application of delayed coking structure - oriented lumping model 显示文摘 | Tian Lida Shen Benxian Liu Jichang | 2012 | Ind Eng Chem Res2012，51，10： | 1 |
| 13 | Additive manufacturing of bone scaffolds显示文摘Additive manufacturing(AM)can obtain not only customized external shape but also porous internal structure for scaffolds,both of which are of great importance for repairing large segmental bone defects.The scaffold fabrication process generally involves scaffold design,AM,and post-treatments.Thus,this article firstly reviews the state-of-the-art of scaffold design,including computer-aided design,reverse modeling,topology optimization,and mathematical modeling.In addition,the current characteristics of several typical AM techniques,including selective laser sintering,fused deposition modeling(FDM),and electron beam melting(EBM),especially their advantages and limitations are presented.In particular,selective laser sintering is able to obtain scaffolds with nanoscale grains,due to its high heating rate and a short holding time.However,this character usually results in insufficient densification.FDM can fabricate scaffolds with a relative high accuracy of pore structure but with a relative low mechanical strength.EBM with a high beam-material coupling efficiency can process high melting point metals,but it exhibits a low-resolution and poor surface quality.Furthermore,the common post-treatments,with main focus on heat and surface treatments,which are applied to improve the comprehensive performance are also discussed.Finally,this review also discusses the future directions for AM scaffolds for bone tissue engineering. | Youwen Yang Guoyong Wang Huixin Liang Chengde Gao Shuping Peng Lida Shen Cijun Shuai | 2019 | International Journal of Bioprinting2019，5，1： | 1 |
| 14 | Synthesis, crystal structures and characterization of three cadmium(II) metal–organic coordination complexes constructed from flexible bis(imidazole) and carboxybenzaldehyde ligands显示文摘 | Xiao-Li Wang Lida Hashemi Ling-Hui Tu Si-Yao Wang Yi Shen Bi-Feng Huang Hong-Ping Xiao Vahid Safarifard Ali Morsali | 2014 | Journal of Molecular Structure2014，，： | 1 |
| 15 | Building and applica- tion of delayed coking structure-oriented lumping model显示文摘 | Tian Lida Shen Benxian Liu Jichang | 2012 | Ind Eng Chem Res2012，51，10： | 1 |
| 16 | In-situ deposition of apatite layer to protect Mg-based composite fabricated via laser additive manufacturing显示文摘Biodegradable magnesium(Mg) and its alloy show huge potential as temporary bone substitute due to the favorable biocompatibility and mechanical compatibility. However, one issue deserves attention is the too fast degradation. In this work, mesoporous bioglass(MBG)with high pore volume(0.59 cc/g) and huge specific surface area(110.78 m^(2)/g) was synthesized using improved sol-gel method, and introduced into Mg-based composite via laser additive manufacturing. Immersion tests showed that the incorporated MBG served as powerful adsorption sites, which promoted the in-situ deposition of apatite by successively adsorbing Ca2+and HPO42-. Such dense apatite film acted as an efficient protection layer and enhanced the corrosion resistance of Mg matrix, which was proved by the electrochemical impedance spectroscopy measurements. Thereby, Mg based composite showed a significantly decreased degradation rate of 0.31 mm/year. Furthermore,MBG also improved the mechanical properties as well as cell behavior. This work highlighted the advantages of MBG in the fabrication of Mg-based implant with enhanced overall performance for orthopedic application. | Youwen Yang Changfu Lu Lida Shen Zhenyu Zhao Shuping Peng Cijun Shuai | 2023 | Journal of Magnesium and Alloys2023，11，2： | 1 |
| 17 | 查看详情显示文摘 | Wang Dongsheng Tian Zongjun Shen Lida | | 0，，04： | 1 |
| 18 | Building a kinetic model for steam cracking by the method of structure oriented lumping显示文摘 | TIAN Lida WANG Jiming SHEN Benxian | 2010 | Energy & Fuels2010，24，8： | 1 |
| 19 | Effects of lase1 remelting on microstructure and solid particle erosion characteristic1 of ZrO-7wt% Y203 thermal barrier coating prepared by plasma1 praying显示文摘 | Dongsheng Wang Zongjun Tian Lida Shen | 2014 | Science Direct2014，40，6： | 1 |
| 20 | Building and application of delayed coking structure -oriented lumping model 显示文摘 | Tian Lida Shen Benxian Liu Jichang | 2012 | Industrial & Engineering Chemistry Research2012，51，30： | 1 |
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