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| 1 | Learning-based lensless imaging through optically thick scattering media显示文摘The problem of imaging through thick scattering media is encountered in many disciplines of science,ranging from mesoscopic physics to astronomy.Photons become diffusive after propagating through a scattering medium with an optical thickness of over 10 times the scattering mean free path.As a result,no image but only noise-like patterns can be directly formed.We propose a hybrid neural network for computational imaging through such thick scattering media,demonstrating the reconstruction of image information from various targets hidden behind a white polystyrene slab of 3 mm in thickness or 13.4 times the scattering mean free path.We also demonstrate that the target image can be retrieved with acceptable quality from a very small fraction of its scattered pattern,suggesting that the speckle pattern produced in this way is highly redundant.This leads to a profound question of how the information of the target being encoded into the speckle is to be addressed in future studies. | Meng Lyu Hao Wang Guowei Li Shanshan Zheng Guohai Situ | 2019 | Advanced Photonics2019，1，3： | 28 |
| 2 | Three-field vs two-field lymph node dissection for esophageal cancer:A meta-analysis显示文摘AIM:To assess the effects of 3-field lymphadenectomy for esophageal carcinoma.METHODS:We conducted a computerized literature search of the Pub Med,Cochrane Controlled Trials Register,and EMBASE databases from their inception to present.Randomized controlled trials(RCTs)or observational epidemiological studies(cohort studies)that compared the survival rates and/or postoperative complications between 2-field lymphadenectomy(2FL)and3-field lymphadenectomy(3FL)for esophageal carcinoma with R0 resection were included.Meta-analysis was conducted using published data on 3FL vs 2FL in esophageal carcinoma patients.End points were 1-,3-,and 5-year overall survival rates and postoperativecomplications,including recurrent nerve palsy,anastomosis leak,pulmonary complications,and chylothorax.Subgroup analysis was performed on the involvement of recurrent laryngeal lymph nodes.RESULTS:Two RCTs and 18 observational studies with over 7000 patients were included.There was a clear benefit for 3FL in the 1-(RR=1.16;95%CI:1.09-1.24;P<0.01),3-(RR=1.44;95%CI:1.19-1.75;P<0.01),and 5-year overall survival rates(RR=1.37;95%CI:1.18-1.59;P<0.01).For postoperative complications,3FL was associated with significantly more recurrent nerve palsy(RR=1.43;95%CI:1.28-1.60;P=0.02)and anastomosis leak(RR=1.26;95%CI:1.05-1.52;P=0.09).In contrast,there was no significant difference for pulmonary complications(RR=0.93;95%CI:0.75-1.16,random-effects model;P=0.27)or chylothorax(RR=0.77;95%CI:0.32-1.85;P=0.69).CONCLUSION:This meta-analysis shows that 3FL improves overall survival rate but has more complications.Because of the high heterogeneity among outcomes,definite conclusions are difficult to draw. | Guo-Wei Ma Dong-Rong Situ Qi-Long Ma Hao Long Lan-Jun Zhang Peng Lin Tie-Hua Rong | 2014 | World Journal of Gastroenterology2014，20，47： | 25 |
| 3 | Conceptual design and aerodynamic evaluation of hypersonic airplane with double flanking air inlets显示文摘To aim at design requirements of high lift-to-drag ratio as well as high volumetric efficiency of next generation hypersonic airplanes,a body-wing-blending configuration with double flanking air inlets layout is presented.Moreover,a novel forebody design methodology which by rotating and assembling two waverider-based surfaces is firstly introduced in this paper.Some typical configurations are designed and their aerodynamic performances are evaluated by computational fluid dynamics.The results for forebodies analysis show that large volumetric efficiency,high lift-to-drag ratio,and uniformly distributed flowfield at the inlet cross section can be assured simultaneously.Furthermore,results of numerical simulation of four integrated configurations with various leading edge shapes,including three power-law curves and a cosine curve clearly show the advantage of high lift-to-drag ratio.Besides,the high pressure generated by the side wall of the airframe can be partly captured by the reasonably designed wings in the condition of small flight attack angle.Then the order of lift-to-drag ratio of four configurations at 0 degree flight attack angle is completely different from the condition of 4-degree flight attack angle.This result demonstrates that the curve shape of the leading edge is very important for the lift-to-drag ratio of the aircraft,and it should be further optimized under the cruising attack angle in future work. | CUI Kai HU ShouChao LI GuangLi QU ZhiPeng SITU Ming | 2013 | Science China(Technological Sciences)2013，56，8： | 10 |
| 4 | Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells显示文摘In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopharyngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the expression of c-myc, bax, bcl-2 proteins by use of Hoechst 33258 staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), agarose gel electrophoresis, and flow cytometry, as well as Western blot analysis. The results showed that heparin induced apoptosis of CNE2 cells including the morphologic changes such as reduction in the volume, and the nuclear chromatin condensation, as well as the “ladder pattern” revealed by agarose gel electrophoresis of DNA in a concentration-dependent manner.The number of TUNEL-positive cells was dramatically increased to 33.6±1.2% from 2.8±0.3% by treat ment with heparin in different concentrations (10~40 kU/L). The apoptotic index was increased to 32.5% from 3.5% by detecting SubG1 peaks on flow cytometry. Western blot analysis showed that levels of bcl-2,bax and c-myc were significantly overexpressed by treatment with the increase of heparin concentrations.These results suggest that heparin induces apoptosis of CNE2 cells, which may be regulated by differential expression of apoptosis-related genes. | LI HONG LIANG , KAI HE YE , HAI WEI ZHANG , YING RU LUO , XIAN DA REN, AI HUA XIONG, RUI SITU Department of Pharmacology ,Pharmacy College, Department of Pathology Medical College, Jinan University, Guangzhou 510632, China | 2001 | Cell Research2001，11，4： | 9 |
| 5 | Deep-learning-based ciphertext-only attack on optical double random phase encryption显示文摘Optical cryptanalysis is essential to the further investigation of more secure optical cryptosystems.Learning-based at-tack of optical encryption eliminates the need for the retrieval of random phase keys of optical encryption systems but it is limited for practical applications since it requires a large set of plaintext-ciphertext pairs for the cryptosystem to be at-tacked.Here,we propose a two-step deep learning strategy for ciphertext-only attack(COA)on the classical double ran-dom phase encryption(DRPE).Specifically,we construct a virtual DRPE system to gather the training data.Besides,we divide the inverse problem in COA into two more specific inverse problems and employ two deep neural networks(DNNs)to respectively learn the removal of speckle noise in the autocorrelation domain and the de-correlation operation to retrieve the plaintext image.With these two trained DNNs at hand,we show that the plaintext can be predicted in real-time from an unknown ciphertext alone.The proposed learning-based COA method dispenses with not only the retrieval of random phase keys but also the invasive data acquisition of plaintext-ciphertext pairs in the DPRE system.Numerical simulations and optical experiments demonstrate the feasibility and effectiveness of the proposed learning-based COA method. | Meihua Liao Shanshan Zheng Shuixin Pan Dajiang Lu Wenqi He Guohai Situ Xiang Peng | 2021 | Opto-Electronic Advances2021，4，5： | 7 |
| 6 | Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma显示文摘AIM: To study the expression of β-catenin in esophageal squamous cell carcinoma (ESCC) at stage T2-3N0M0 and its relation with the prognosis of ESCC patients. METHODS: Expression of β-catenin in 227 ESCC speci-mens was detected by immunohistochemistry (IHC). A reproducible semi-quantitative method which takes both staining percentage and intensity into account was applied in IHC scoring, and receiver operating char-acteristic curve analysis was used to select the cut-off score for high or low IHC reactivity. Then, correlation of β-catenin expression with clinicopathological features and prognosis of ESCC patients was determined. RESULTS: No significant correlation was observed between β-catenin expression and clinicopathological parameters in terms of gender, age, tumor size, tumor grade, tumor location, depth of invasion and pathologi-cal stage. The Kaplan-Meier survival curve showed that the up-regulated expression of β-catenin indicated a poorer post-operative survival rate of ESCC patients at stage T2-3N0M0 (P = 0.004), especially of those with T3 lesions (P = 0.014) or with stage ⅡB diseases (P = 0.007). Multivariate analysis also confirmed that β-catenin was an independent prognostic factor for the overall survival rate of ESCC patients at stage T2-3N0M0 (relative risk = 1.642, 95% CI: 1.159-2.327, P = 0.005). CONCLUSION: Elevated β-catenin expression level may be an adverse indicator for the prognosis of ESCC patients at stage T2-3N0M0, especially for those with T3 lesions or stage ⅡB diseases. | Dong-Rong Situ Yi Hu Zhi-Hua Zhu Jian Wang Hao Long Tie-Hua Rong | 2010 | World Journal of Gastroenterology2010，16，41： | 7 |
| 7 | Far-field super-resolution ghost imaging with a deep neural network constraint显示文摘Ghost imaging(GI)facilitates image acquisition under low-light conditions by single-pixel measurements and thus has great potential in applications in various fields ranging from biomedical imaging to remote sensing.However,GI usually requires a large amount of single-pixel samplings in order to reconstruct a high-resolution image,imposing a practical limit for its applications.Here we propose a far-field super-resolution GI technique that incorporates the physical model for GI image formation into a deep neural network.The resulting hybrid neural network does not need to pre-train on any dataset,and allows the reconstruction of a far-field image with the resolution beyond the diffraction limit.Furthermore,the physical model imposes a constraint to the network output,making it effectively interpretable.We experimentally demonstrate the proposed GI technique by imaging a flying drone,and show that it outperforms some other widespread GI techniques in terms of both spatial resolution and sampling ratio.We believe that this study provides a new framework for GI,and paves a way for its practical applications. | Fei Wang Chenglong Wang Mingliang Chen Wenlin Gong Yu Zhang Shensheng Han Guohai Situ | 2022 | Light(Science & Applications)2022，11，1： | 6 |
| 8 | Incoherent imaging through highly nonstatic and optically thick turbid media based on neural network显示文摘Imaging through nonstatic scattering media is one of the major challenges in optics, and encountered in imaging through dense fog, turbid water, and many other situations. Here, we propose a method to achieve single-shot incoherent imaging through highly nonstatic and optically thick turbid media by using an end-to-end deep neural network. In this study, we use fat emulsion suspensions in a glass tank as a turbid medium and an additional incoherent light to introduce strong interference noise. We calibrate that the optical thickness of the tank of turbid media is as high as 16, and the signal-to-interference ratio is as low as -17 dB. Experimental results show that the proposed learning-based approach can reconstruct the object image with high fidelity in this severe environment. | SHANSHAN ZHENG HAO WANG SHI DONG FEI WANG GUOHAI SITU | 2021 | Photonics Research2021，9，5： | 5 |
| 9 | Single-port laparoscopic radical prostatectomy: initial experience and technical points to reduce its difficulties显示文摘背景 Laparoendoscopic 单个地点的外科(更少)途径为对待各种各样的肾和骨盆的过程被报导了,并且在选择 patients.In 可行、有效这研究,我们试图介绍起始的经验并且评估前列腺切除术用在2010年7月和2011年4月之间的多信道的 port.Methods 通过一个单个切口执行了的 laparoscopic 基的功效,与早阶段前列腺癌症诊断的六个病人经历了不太激进的前列腺切除术( RP ) | WEN Xing-qiao HUANG Wen-tao SITU Jie HU Cheng YE Chun-wei GAO Xin | 2011 | Chinese Medical Journal2011，，23： | 5 |
| 10 | Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery显示文摘 | LI Ke CHEN Ming-kun SITU Jie HUANG Wen-tao SU Zu-lan HE Dan GAO Xin | 2013 | Chinese Medical Journal2013，，1： | 5 |
| 11 | A PILOT TRIAL FOR SEVERE ,REFRACTORY SYSTEMIC AUTOIMMUNE DISEASE WITH STEM CELL TRANSPLANTATION显示文摘Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy (HDIT) and autolo- gous hemopoietic stem cell transplantation (HSCT) with CD34+ cell selection in patients with severe, refractory autoim- mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjgren’s syndrome (pSS), or systemic sclerosis (SSc) who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Results Overall treatment related mortality was 7.7% (2/26) with 1 patient died of cytomegalovirus infection and an- other of severe pneumonia. Relapse occurred in 3 SLE patients (17.6%) in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index (SLEDAI) scores of SLE survivors decreased significantly (P < 0.01). RA patients recorded a drop of Disease Activity Score 28 (DAS 28). The pSS patient remained symptoms free up to now, more than 50 months after the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients. | Xiao-mei Leng Yan Zhao Dao-bing Zhou Huifen Situ Tai-sheng Li Ti Shen Yong-qiang Zhao Xiao-feng Zeng Feng-chun Zhang Yi Dong Fu-lin Tang | 2005 | Chinese Medical Sciences Journal2005，20，3： | 4 |
| 12 | Two novel gastric cancer-associated genes identified by differential display显示文摘TwonovelgastriccancerassociatedgenesidentifiedbydiferentialdisplayYOUHan,XIAOBing,CUIDaXiang,SHIYongQuanandFANDaiMingSubj... | YOU Han, XIAO Bing, CUI DaXiang, SHI YongQuan and FAN DaiMingKeywords stomach neoplasms gene clone nucleotides sequence analysis in situ hybridization polymerase chain reaction RNA, messenger | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 13 | Polarization multiplexing for double images display显示文摘Metasurface provides subwavelength structures for manipulating wavefronts of light. The benefits of subwavelength components offer a continuous modulation of amplitude, phase, and polarization, thus eliminating the production of higher-order images and improving the utilization of light intensity. Despite the rapid progress in this field, multiparameter control of light using single layer metasurface is rarely reported. In fact, multiparameter control of light helps to improve information storage capacity and image fidelity. With simultaneous manipulation of polarization and amplitude at each pixel, it is possible to encode two separate images into one metasurface and reconstruct them under proper conditions. In a proof of concept experiment, we demonstrate an independent display of two binary images at the same position with polarization de-multiplexing from a single metasurface. This unique technology of encoding two images through amplitude and polarization manipulation provides a new opportunity for various applications in, such as encryption, information storage, polarization holograms, optical communications and fundamental physics. | Jinying Guo Teng Wang Baogang Quan Huan Zhao Changzhi Gu Junjie Li Xinke Wang Guohai Situ Yan Zhang | 2019 | Opto-Electronic Advances2019，2，7： | 4 |
| 14 | Expression of alpha-fetoprotein messenger RNA in BEL-7404 human hepatoma cells and effect of L-4-oxalysine on the expression显示文摘ExpressionofalphafetoproteinmessengerRNAinBEL7404humanhepatomacelsandefectofL4oxalysineontheexpressionWANGXingWangandXU... | WANG XingWang and XU BinKeywords oxalysine liver neoplasms fetoprotein tumor cell, cultured RNA, messenger gene expression in situ hybridization immunohistochemistry | 1998 | World Journal of Gastroenterology1998，4，4： | 3 |
| 15 | A Clinical Study on the Treat ment of Chronic Pelvic Inflammation of Qi-stagnation with Blood Stasis Syndrome by Penyanqing Capsule (盆炎清胶囊)显示文摘Objective: To observe the clinical efficacy of Penyanqing Capsule (盆炎清胶囊,PYQC) in treating pelvic inflammation of Qi-stagnation with blood stasis syndrome. Methods: The randomized, single blinded, parallel positive drug controlled method was adopted, with 82 patients assigned into two groups by envelop method. The 42 patients in the treated group received PYQC 3 times a day, 4 capsules each time taken orally; the 40 patients in the control group were given orally Fuyankang tablets (妇炎康片, FYKT) 3 times a day, 6 tablets each time. The therapeutic course for both groups was 2 months, and 2 courses of treatment were given successively to observe the comprehensive effect, changes of symptoms and signs before and after treatment. The effects of PYQC on hemorrheological character in part of the patients and on the pathogenetic chlamydia and mycoplasma were also observed. Results: The total effective rate in the treated group was 83.3%, which was insignificantly different from that in the control group (77.5%, P>0.05). However, PYQC could significantly lower the hemorrheologic indexes in patients and showed definite influence on the pathogenetic chlamydia and mycoplasma. Conclusion: PYQC has good therapeutic effect in treating chronic pelvic inflammation of Qi-stagnation with blood stasis syndrome, and showed definite effect on chlamydia and mycoplasma. | SHEN Bi-qiong(沈碧琼) SITU Yi(司徒仪) HUANG Jian-ling(黄健玲) SU Xiao-mei(苏晓梅) HE Wei tang(何伟棠) ZHANG Mao-wei(张茂威) CHEN Qu-bo(陈曲波) | 2005 | Chinese Journal of Integrated Traditional and Western Medicine2005，11，4： | 3 |
| 16 | Photocatalytic activity of TiO2 containing anatase nanoparticles and rutile nanoflower structure consisting of nanorods显示文摘A series of TiO2 with diferent crystal phases and morphologies was synthesized via a facile hydrothermal process using titanium n- butoxide and concentrated hydrochloric acid as raw materials. The photocatalytic activity of the samples was evaluated by degradation of Methyl Orange in aqueous solution under UV-Visible light irradiation. On the basis of detailed analysis of the characterizing results of high-resolution transmission electron microscopy, X-ray powder difraction measurements, X-ray photoelectron spectroscopy and Brunauer-Emmett-Teller measurement, it was concluded that the photo-activity of the catalyst is related directly to the 3D morphology and the crystal phase composition. An excellent catalyst should have both a rutile 3D flower-like structure and anatase granulous particles. The 3D flower-like structure could enhance light harvesting, as well as the transfer of reactant molecules from bulk solution to the reactive sites on TiO2. In addition, the optimum anatase/rutile phase ratio was found to be 80:20, which is beneficial to the efective separation of the photogenerated electron–hole pairs. | Zhiqiao He Qiaolan Cai Huiying Fang Gaohua Situ Jianping Qiu Shuang Song Jianmeng Chen | 2013 | Journal of Environmental Sciences2013，25，12： | 3 |
| 17 | Synthesis and antiviral activity of some novel indole-2-carboxylate derivatives显示文摘A series of novel indole-2-carboxylate derivatives were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities.The biological results showed that some of the synthesized compounds exhibited potent broad-spectrum antiviral activity.Notably,compound 8f showed the highest SI value(17.1)to Cox B3 virus.Compound 14f showed both potent inhibitory activity against influenza A(IC_(50)=7.53μmol/L)and the highest SI value(12.1).SAR results showed that the alkyloxy at the 4-position of indole ring was not crucial to the antiviral activities.Incorporation of an acetyl substituent at the amino group disfavored antiviral activity towards RNA viruses. | Situ Xue Linlin Ma Rongmei Gao Yuhuan Li Zhuorong Li | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 3 |
| 18 | Phase imaging with an untrained neural network显示文摘Most of the neural networks proposed so far for computational imaging(CI)in optics employ a supervised training strategy,and thus need a large training set to optimize their weights and biases.Setting aside the requirements of environmental and system stability during many hours of data acquisition,in many practical applications,it is unlikely to be possible to obtain sufficient numbers of ground-truth images for training.Here,we propose to overcome this limitation by incorporating into a conventional deep neural network a complete physical model that represents the process of image formation.The most significant advantage of the resulting physics-enhanced deep neural network(PhysenNet)is that it can be used without training beforehand,thus eliminating the need for tens of thousands of labeled data.We take single-beam phase imaging as an example for demonstration.We experimentally show that one needs only to feed PhysenNet a single diffraction pattern of a phase object,and it can automatically optimize the network and eventually produce the object phase through the interplay between the neural network and the physical model.This opens up a new paradigm of neural network design,in which the concept of incorporating a physical model into a neural network can be generalized to solve many other CI problems. | Fei Wang Yaoming Bian Haichao Wang Meng Lyu Giancarlo Pedrini Wolfgang Osten George Barbastathis Guohai Situ | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 19 | Numerical model to quantify biogenic volatile organic compound emissions:The Pearl River Delta region as a case study显示文摘This article compiles the actual knowledge of the biogenic volatile organic compound(BVOC) emissions estimated using model methods in the Pearl River Delta(PRD) region, one of the most developed regions in China. The developed history of BVOC emission models is presented briefly and three typical emission models are introduced and compared. The results from local studies related to BVOC emissions have been summarized. Based on this analysis, it is recommended that local researchers conduct BVOC emission studies systematically, from the assessment of model inputs, to compiling regional emission inventories to quantifying the uncertainties and evaluating the model results. Beyond that,more basic researches should be conducted in the future to close the gaps in knowledge on BVOC emission mechanisms, to develop the emission models and to refine the inventory results. This paper can provide a perspective on these aspects in the broad field of research associated with BVOC emissions in the PRD region. | Xuemei Wang Shuping Situ Weihua Chen Junyu Zheng Alex Guenther Qi Fan Ming Chang | 2016 | Journal of Environmental Sciences2016，28，8： | 2 |
| 20 | Heterotetranuclear Cu_2~IPd_2~Ⅱ Complex with Bis(diphenylphosphino)methane and Diethyldithiocarbamate显示文摘Self-assembly between the building blocks of Pd(Et2dtc)2 (Et2dtc = diethyldithio- carbamate) and [Cu2(m-dppm)2(MeCN)2]2+ (dppm = bis(diphenylphosphino)methane) gave a new heterotetranuclear complex [Cu2Pd2(m-dppm)2(m-Et2dtc)2(m3-Et2dtc)2](ClO4)2H2O (C70H86Cl2Cu2- N4O9P4Pd2S8, Mr = 1932.56), and its crystal structure has been determined by X-ray crystallo- graphy. It crystallizes in triclinic, space group P with a = 11.9834(6), b = 12.5624(6), c = 14.5603(8) ? a = 101.393 (1), b = 103.300 (1), g = 96.310(1), V = 2063.2(2) 3, Z = 1, Dc = 1.544 g/cm3, m(MoKa) = 1336 cm-1 and F(000) = 978. The total and unique reflections are 8710 and 5400, respectively. The structure was refined to R = 0.0860 and wR = 0.1996 for 3914 observed reflections with I > 2s(I). The title complex consists of the cation [Cu2Pd2(m-dppm)2(m-Et2dtc)2(m3- Et2dtc)2]2+, anion ClO4- and solvate H2O. The Pd(Ⅱ) atoms are located at the approximately square-planar environments with PS3 donors and the Cu(I) atoms display distorted tetrahedral geometries. | SITU Yue HUANG Shao-Bin (Department of Applied Chemistry, South China University of Technology, Guangzhou, Guangdong 510640, China) | 2003 | Chinese Journal of Structural Chemistry2003，22，4： | 2 |
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