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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice显示文摘 | Collins Meredith A Bednar Filip Zhang Yaqing Brisset Jean-Christophe Galbán Stefanie Galbán Craig J Rakshit Sabita Flannagan Karen S Adsay N Volkan di Magliano Marina Pasca | 2012 | EN2012，，： | 3 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility显示文摘 | Ignatiadis Michail Lee Mark Jeffrey Stefanie S | 2015 | Clinical Cancer Research2015，，21： | 2 |
| 5 | Polyurethane-ductilized epoxy resins显示文摘 | STEFANI P M MOSCHIAR S M ARANGUREN M I | 1998 | J Appl Polym Sci1998，68，11： | 1 |
| 6 | A methodology for minimum environmental impact analysis显示文摘 | PISTIKOPOULOS E N STEFANIS S K LIVINGSTON A G | 1994 | AICh E Symposium1994，90，303： | 1 |
| 7 | A methodology for environmental impact minimization:solvent design and reaction path synthesis issues显示文摘 | Stefanis S K Buxton A Livingston A G Pistikopoulos E N | 1996 | Computers & Chemical Engineering1996，20，： | 1 |
| 8 | Non Sedgkm lymphoma of the ureter; a rare disease 显示文摘 | Celia A De Stefani S Bruschi M | 2004 | Arch Ital Urol Androl2004，76，4： | 1 |
| 9 | Biofeed-back,electrical stimulation,pelvic floor muscle exercises,and vaginal cones:a combined rehabilitative approach for sexual dysfunction associated with urinary incontinence显示文摘 | Rivalta M Sighinolfi M C De Stefani S | | 0，，06： | 1 |
| 10 | Biofeedback, electrical stimulation, pelvic floor muscle exercises, and vaginal cones: a com- bined rehabilitative approach for sexual dysfunction associated with urinary incontinence显示文摘 | Rivalta M Sighinolfi MC De Stefani S | 2009 | J Sex Med2009，6，： | 1 |
| 11 | The serendipity case of the pedunculopontine nucleus low-frequency brain stimulation:chasing a gait response,finding sleep,and cognition improvement显示文摘 | Stefani A Peppe A Galati S | 2013 | Front Neurol2013，4，： | 1 |
| 12 | Evolution in the antibiotic susceptibility and resistance显示文摘 | STEFANI S | 2009 | Infez Med2009，17，3： | 1 |
| 13 | Noninvasive management of obstructing ureteral stones using electromagnetic extracorporeal shock wave lithotripsy显示文摘 | Sighinolfi M C Micali S De Stefani S | 2008 | Surg Endosc2008，22，5： | 1 |
| 14 | Retroperitoneal laparoendo- scopic single-site surgery:perliminary experience in kidney and u- reteral indications 显示文摘 | Micali S Isgr: G De Stefani S | 2011 | Eur Urel2011，59，1： | 1 |
| 15 | Molecular epidemiology of antibiotic resistance显示文摘 | Stefani S Agodi A | 2000 | In J Antimicrob Agents2000，13，3： | 1 |
| 16 | Numerical Modeling of melt-wave erosion in conductors显示文摘 | Benton T Stefani F Satapathy S | 2003 | IEEE Transactions on Magnetics2003，39，1： | 1 |
| 17 | Molecular epidemology of antibiotic resistance显示文摘 | Stefani S Agodi A | 2000 | Int J Antimicrob Agents2000，13，3： | 1 |
| 18 | Polyurethane- ductilized epoxy resins 显示文摘 | Stefani P M Moschiar S M Aranguren M I | 1998 | Journal of Applied Polymer Science1998，68，11： | 1 |
| 19 | Expression of cell cycle-related proteins in developiugand adult mouse hippocampus显示文摘 | Stefanie S Ulrich G Thomas A | 2005 | Int J Devl Neuro2005，23，8： | 1 |
| 20 | Squamous cell carcinoma of the prostate显示文摘 | Di Pietro C Celia A De Stefani S | 2006 | Arch Ital Urol Androl2006，78，2： | 1 |
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