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| 1 | Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment显示文摘Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor regions.In recent years,large-scale genomic studies and new next-generation sequencing technologies have uncovered more scientifc details about tumor heterogeneity,with significant implications for the choice of specific molecular biomarkers and clinical decision making Genomic heterogeneity signifcantly contributes to the generation of a diverse cell population during tumor development and progression,representing a determining factor for variation in tumor treatment response.It has been considered a prominent contributor to therapeutic failure,and increases the likelihood of resistance to future therapies in most common cancers.The understanding of molecular heterogeneity in cancer is a fundamental component of precision oncology,enabling the identification of genomic alteration of key genes and pathways that can be targeted therapeutically.Here,we review the emerging knowledge of tumor genomics and heterogeneity,as well as potential implications for precision medicine in cancer treatment and new therapeutic discoveries.An analysis and interpretation of the TCGA database was included. | Jialing Zhang Stephan Stanislaw Späth Sadie L.Marjani Wengeng Zhang Xinghua Pan | 2018 | Precision Clinical Medicine2018，1，1： | 5 |
| 2 | Flexibility training:ballistic,static or proprioceptive neuromuscular facilitation显示文摘 | Sady SP Wortman M Blanke D | 1982 | Arch Phys Med Rehabil1982，63，8： | 1 |
| 3 | Contrasting effects of testosterone and stanozo-lol on serum lipoprotein levels显示文摘 | Calleinane EM Sady SP | 1989 | JAMA1989，261，： | 1 |
| 4 | Prolonged exercise augments plasma triglyceride clearance显示文摘 | Sady SP Thompson PD Cullinane EM | | 0，，： | 1 |
| 5 | Modest changes in HDL concentration and metabolism with polonged exercise training显示文摘 | Thompson PD Cullinane EM Sady SP | 1988 | Circulation1988，78，： | 1 |
| 6 | Flexibilitytraining: ballistic, static or proprioceptiveneuromuscular facilitation-显示文摘 | Sady SP Wortman M Blanke D | 1982 | Arch Phys MedRehabil1982，63，6： | 1 |
| 7 | Contrasting effects of testosterone and stanozolol on serum lipoprotein levels显示文摘 | Thompson PD Calleinane EM Sady SP | 1989 | JAMA1989，261，： | 1 |
| 8 | Prolonged exercise augments plasma triglyceride clearance显示文摘 | Sady SP | | Journal of the American Medical Association0，256，： | 1 |
| 9 | Prolonged exercise augments plasma triglyceride clearance 显示文摘 | Sady SP | 1996 | JAMA1996，256，： | 1 |
| 10 | Contrasting effects of testosterone and stenomlol on serum lipoprotein leveles显示文摘 | Thompson PD Calleinnane EM Sady SP | 1989 | JAMA1989，261，： | 1 |
| 11 | Flexibility training:ballistic,static or proprioceptive neuromuscular facilitation显示文摘 | Sady SP Wortman M Blanke D | 1982 | Arch Phys Med Rehabil1982，63，6： | 1 |
| 12 | Contrasting effects of testosterone and stanozolol on serum lipoprotein levels显示文摘 | Cullinane EM Sady SP | 1989 | JAMA1989，261，8： | 1 |
| 13 | Modest Changes in High-Density Lipoprotein Concentrations and Metabolism with Prolonged Exercise Training显示文摘 | Thompson PD Cullinane EM Sady SP | 1988 | Circulation1988，78，： | 1 |
| 14 | High density lipoprotein metabolism in endurance athletes and sedentary men显示文摘 | Thompson PD Cullinane EM Sady SP | 1991 | Circulation1991，84，1： | 1 |
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