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| 1 | Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea显示文摘瞄准:估计酵母属 boulardii 的功效和安全(S。boulardii ) 在在减少腹泻的事件的频率在的尖锐水的腹泻和它的角色随后二个月。方法:从 2 瞬间的孩子到 12 岁,在 S 根据包括标准和随机的 ised 与尖锐腹泻被选择。boulardii 组(与 ORS,营养的支持和 S 一起对待。boulardii, 250 mg 出价) 并且在控制组(仅仅与 ORS 和营养的支持一起对待) 。直接疗法阶段是 5 d,每个孩子以后被跟随二个月。象药的安全一样的凳子的频率和一致性在每访问上被估计。二个组的比较以痢疾的事件的数字被做在随后二个月。结果:在每个组有五十个病人。象吝啬的年龄和凳子的平均频率那样的基线特征在 S 是可比较的。boulardii 和控制在试用在包括的时候组织。由 d 3 它分别地并且由 d 每 d 归结为 2.7 和 4.2 张凳子 6 它归结为 1.6 (S。boulardii 组) 并且 3.3 (控制组) 。腹泻的持续时间是在 S 的 3.6 d。而它是在控制组的 4.8 d, boulardii 组织(P = 0.001 ) 。在下列二个月内, S。有的 boulardii 组一显著地, 0.54 个事件的低频率作为与在控制的 1.08 个事件相比组织。这药很好被接受并且容忍。在治疗时期期间没有副作用的报告。结论:S。boulardii 显著地减少尖锐腹泻的频率和持续时间。凳子的一致性也改善。这药是容忍得好的。 | AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi | 2006 | World Journal of Gastroenterology2006，12，28： | 22 |
| 2 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 3 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Archean blocks and their boundaries in the North China Craton: lithological, geochemical, structural and P-T path constraints and tectonic evolution 显示文摘 | Zhao G C Wilde SA Cawood P A Sun M | 2001 | Precambrian Research2001，107，： | 1 |
| 6 | Role of mitochondrial dna damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression 显示文摘 | MADSEN-BOUTERSE SA MOHAMMAD G KANWAR M KOWLURU RA | 2010 | Antioxid Redox Signal2010，13，6： | 1 |
| 7 | ACC/AHA guidelines for the martagement of patients with ST-elevation myocardial infarction-executive summary:port of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of patients with Acute Myocardial Infarction) 显示文摘 | Antman EM Anbe DT Armstrong PW Bates ER Green LA Hand M Hochman JS Krumholz HM Kushner FG Lamas GA Mullany CJ Ornato JP pearle DL Sloan MA Smith SCJr Alpert JS Anderson JL Faxon DP Fuster V Gibbons RJ Gregoratos G Halperin JL Hiratzka LF Hunt SA Jacobs AK American College of Cardiology American Heart Association Task Force on Practice Guidelines | 2004 | Circulation2004，110，5： | 1 |
| 8 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 9 | Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts显示文摘 | Saed G M Diamond M P | 2003 | Fertility stertility2003，79，1： | 1 |
| 10 | Autocrine effects of IGF-Ⅰ-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19显示文摘 | Slomiany M G Rosenzweig SA | 2004 | Am J Physiol Cell Physiol2004，287，3： | 1 |
| 11 | How good is ultrasound in the detection and evaluation of anterior abdominal wall defects? 显示文摘 | Walkinshaw SA Renwiek M Hebisch G | 1992 | BrJ Radiol1992，65，772： | 1 |
| 12 | Crab and cockle shells as catalysts for the preparation of methyl esters from low FF A chicken fat显示文摘 | BOEY P L MANIAM G P HAMID SA ALI D M H | 2011 | J Am Oil Chern Soc2011，88，2： | 1 |
| 13 | Evaluation of ionic air purifiers for reducing aerosol exposure in confined indoor spaces 显示文摘 | Grinshpum SA Mainelis G Trunov M | 2005 | Indoor air2005，15，： | 1 |
| 14 | Promoting Wfeight loss in type 2 diabetes显示文摘 | Brown SA Upchurch S Anding R Winter M Ramirez G | | 0，，： | 1 |
| 15 | Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations显示文摘 | UNER M WISSING SA YENER G | 2004 | Pharmazie2004，59，4： | 1 |
| 16 | Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro,Brazil显示文摘 | Gutierrez-Galhardo M C do Valle G F Sa F C | 2005 | Rev Inst Med Trop Sao Paulo2005，47，： | 1 |
| 17 | with soybean meal-induced enteritis显示文摘 | Bakke-McKeUep A M Press C M Baeverfjord G et aLChanges in im- mune and enzyme histochemical phenotypes of cells in the intestinal mucosa of Atlantic salmon Sa/mo sa/ar L | 2000 | J Fish Dis2000，23，： | 1 |
| 18 | A New Borrelia species defined by multilocus sequence analysis of housekeeping genes 显示文摘 | Margos G Vollmer SA Comet M | 2009 | Appl Environ Microbiol2009，75，16： | 1 |
| 19 | A polynlorphisnl of the human β2-adrenergie receptor within the fourth transmembrane domain alters ligand binding and funetional properties of the receptor显示文摘 | Green SA Cole G Jaeinto M | 1993 | J Biol Chem1993，268，23： | 1 |
| 20 | Alpha-interferon and its effects on signal transduction pathways显示文摘 | Caraglia M Marra M Pelaia G Maselli R Caputi M Marsico SA | 2005 | J Cell Physiol2005，202，2： | 1 |
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