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| 1 | Role of liver transplantation in the management of hepatoblastoma in the pediatric population显示文摘Hepatoblastoma(HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB(unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease(PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient's ranking on the liver transplant list, began to award additional 'exception' points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children's Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras. | Saira Khaderi Jacfranz Guiteau Ronald T Cotton Christine O'Mahony Abbas Rana John A Goss | 2014 | World Journal of Transplantation2014，4，4： | 23 |
| 2 | Impact of immunosuppression on incidence of post-transplant diabetes mellitus in solid organ transplant recipients:Systematic review and meta-analysis显示文摘BACKGROUND Solid organ transplantation is a life-saving intervention for end-stage organ disease.Post-transplant diabetes mellitus(PTDM)is a common complication in solid organ transplant recipients,and significantly compromises long-term survival beyond a year.AIM To perform a systematic review and meta-analysis to estimate incidence of PTDM and compare the effects of the 3 major immunosuppressants on incidence of PTDM.METHODS Two hundred and six eligible studies identified 75595 patients on Tacrolimus,51242 on Cyclosporine and 3020 on Sirolimus.Random effects meta-analyses was used to calculate incidence.RESULTS Network meta-analysis estimated the overall risk of developing PTDM was higher with tacrolimus(OR=1.495%CI:1.0–2.0)and sirolimus(OR=1.8;95%CI:1.5–2.2)than with Cyclosporine.The overall incidence of PTDM at years 2-3 was 17%for kidney,19%for liver and 22%for heart.The risk factors for PTDM most frequently identified in the primary studies were age,body mass index,hepatitis C,and African American descent.CONCLUSION Tacrolimus tends to exhibit higher diabetogenicity in the short-term(2-3 years post-transplant),whereas sirolimus exhibits higher diabetogenicity in the longterm(5-10 years post-transplant).This study will aid clinicians in recognition of risk factors for PTDM and encourage careful evaluation of the risk/benefit of different immunosuppressant regimens in transplant recipients. | Sreelakshmi Kotha Bishoy Lawendy Saira Asim Charlene Gomes Jeffrey Yu Ani Orchanian-Cheff George Tomlinson Mamatha Bhat | 2021 | World Journal of Transplantation2021，11，10： | 5 |
| 3 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 4 | Temperature stability of SmCo(2:17) magnets modified by Ni-Cr two-layer coating显示文摘The oxidation resistance behavior of SmCo(2:17)-type high-temperature magnets modified with Ni-Cr two-layer coating was studied. The study depicts the mass gain kinetics and magnetic properties of uncoated and NiCr-modified magnets oxidized at high temperature(500 ℃) in air for 200 h. The oxidation test results illustrate that the mass gain of uncoated magnet is6.95 mg·cm^(-2) which is more than that(0.08 mg·cm^(-2)) of coated magnet after 200 h. For the magnetic properties concerned, there is a great loss for uncoated magnet, while for coated magnet, magnetic properties do not change much. The study of uncoated magnet through X-ray diffraction(XRD) and electron probe microanalysis(EPMA) shows that the invasion of oxygen at high temperature leads to the loss of magnetic properties by changing the microstructure of magnet. | Saira Bibi Jing-Min Wang M. Faisal Rathore Cheng-Bao Jiang | 2019 | Rare Metals2019，38，3： | 3 |
| 5 | Nitro-tetrazole based high performing explosives:Recent overview of synthesis and energetic properties显示文摘Heterocyclic skeleton(Azoles)and different energetic groups containing high performing explosives are highly emerged in recent years to meet the challenging requirements of energetic materials in both military and civilian applications with improved performance.For this purpose tetrazole(Azole)is identified as an attractive heterocyclic backbone with energetic functional groups nitro(-NO_(2)),nitrato(-ONO_(2)),nitrimino(-NNO_(2)),and nitramino(eNHeNO_(2))to replace the traditionally used high performing explosives.The tetrazole based compounds having these energetic functional groups demonstrated advanced energetic performance(detonation velocity and pressure),densities,and heat of formation(HOF)and became a potential replacement of traditional energetic compounds such as RDX.This review presents a summary of the recently reported nitro-tetrazole energetic compounds containing poly-nitro,di/mono-nitro,nitrato/nitramino/nitrimino,bridged/bis/di tetrazole and nitro functional groups,describing their preparation methods,advance energetic properties,and further applications as highperforming explosives,especially those reported in the last decade.This review aims to provide a fresh concept for designing nitro-tetrazole based high performing explosives together with major challenges and perspectives. | Saira Manzoor Qamar-un-nisa Tariq Xin Yin Jian-Guo Zhang | 2021 | Defence Technology(防务技术)2021，17，6： | 3 |
| 6 | Angiogenic Factors and the Risk of Adverse Outcomes in Women With Suspected Preeclampsia显示文摘 | Sarosh Rana Camille E. Powe Saira Salahuddin Stefan Verlohren Frank H. Perschel Richard J. Levine Kee-Hak Lim Julia B. Wenger Ravi Thadhani S. Ananth Karumanchi | 2012 | Circulation2012，，7： | 2 |
| 7 | Group psychological intervention for maternal depression: A nested qualitative study from Karachi, Pakistan显示文摘AIM To understand the experience of maternal depression, the factors implicated in accessing health, and the acceptability of the psychosocial intervention. METHODS The participants were recruited from the paediatrics outpatient department of Civil Hospital Karachi, Pakistan. The study started in December 2009 and completed in December 2010. Women with maternal depression, aged 18-44 years with children aged 0-30 mo who had received nutritional supplements, and participated in the intervention programme [called Learning through Play(LTP) plus] were included in the study. Qualitative interviews were conducted with 8 participants before the intervention and 7 participants after the intervention. A semi structured topic guide was used to conduct the interviews.RESULTS Framework analysis procedures were used to analyse the qualitative data. Four themes emerged:(1) the women's contextual environment: Interpersonal conflicts, lack of social support and financial issues being the major barriers in assessing healthcare;(2) women's isolation and powerlessness within the environment: Sense of loneliness was identified as a restricting factor to access healthcare;(3) the impact of the intervention(LTP-Plus): Women felt 'listened to' and seemed empowered; and(4) empowered transformed women within the same contextual environment: The facilitator provided a 'gardening role' in nurturing the women resulting in a positive transformation within the same environment. The women's homes seemed to be more happy homes and there was a positive change in their behaviour towards their children.CONCLUSION Findings informed the further development and testing of culturally-appropriate psychosocial intervention(LTP^+) for addressing maternal depression. | Nusrat Husain Nasim Chaudhry Christine Furber Hina Fayyaz Tayyeba Kiran Farah Lunat Raza Ur Rahman Saira Farhan Batool Fatima | 2017 | World Journal of Psychiatry2017，7，2： | 2 |
| 8 | Hot corrosion of surface-modified Sm_(2)Co_(17) high-temperature magnet with Ni and Ni/Cr bilayer coatings in 75 wt% Na_(2)SO_(4)–NaCl mixture显示文摘Hot corrosion behavior of Sm_(2)(Co, Fe, Cu,Zr)17-type high-temperature magnetic alloy without and with a protective coating of Ni and Ni/Cr bilayer at 500 ℃ in a corrosive mixture of 75 wt% Na_(2)SO_(4)–NaCl for 100 h was reported in this paper. The obtained results of timedependent weight change established the parabolic growth of oxidized surface of bare magnets(8.87 mg·cm^(-2)),which caused a rapid loss of magnetic properties measured both at room and high temperatures(500 ℃). X-ray diffraction(XRD) analysis revealed the growth of oxides for bare magnet and Cr–oxides(Cr_(2) O_(3)), top layer of Ni/Cr bilayer coating, but in the case of single coating, Ni–sulfides formation indicated penetration of sulfur, which is further verified by electron probe microanalysis with energy dispersive spectroscopy(EPMA/EDS) study.Results showed that bilayer-coated samples(Ni/Cr) performed better than Ni-coated and bare samples. | Saira Bibi Jing-Min Wang Tariq Mehmood Waheed Qamar Khan Cheng-Bao Jiang | 2021 | Rare Metals2021，40，9： | 2 |
| 9 | The IrrE Protein of Deinococeus radiodurans R1 is a novel regulator of reeA expression 显示文摘 | Ashlee M Earl Michael M Mohundro Saira Mian I John R Battista | 2002 | J Bacteriol2002，184，： | 1 |
| 10 | 溶胶凝胶合成锰掺杂ZnO的室温磁性行为显示文摘通过溶胶凝胶自燃法合成锰掺杂氧化锌纳米晶体,研究了Mn掺杂ZnO稀磁半导体(简称DMS)的性质.X射线衍射光谱表明,锰掺杂氧化锌保留纤锌矿型状氧化锌六角晶体结构.采用能量色散X射线能谱和扫描电子显微镜分别对成分和形态进行研究.温度依赖的电阻率显示了DMS的半导体材料行为.振动样品磁强计测定的室温磁性行为,揭示了锰掺杂氧化锌的铁磁性和反磁性特性. | Murtaza Saleem Saadat A. Siddiqi Shahid Atiq M. Sabieh Anwar Saira Riaz | 2010 | Chinese Journal of Chemical Physics2010，23，4： | 1 |
| 11 | Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer显示文摘OBJECTIVE:To investigate the phytochemicals and in vitro antioxidant,antimicrobial and cytotoxic potential of Rumex dentatus(R.dentatus)leaf extracts.METHODS:The total phenolics and flavonoids content of R.dentatus extracts were evaluated by the Folin-Ciocalteu and aluminum chloride colorimetric methods respectively.Antioxidant potential of studied plant extracts was assessed through 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity,total reducing power and total antioxidant methods.Moreover,antibacterial and antifungal capacity was also evaluated by disc diffusion method against six clinically isolated multi-drug resistant bacterial strains as well as six fungal isolates.Further,cell cytotoxicity was also evaluated through3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay.RESULTS:Ethanol extract showed highest total phenolic[(38.9±1.5)μg gallic acid equivalent/mg]and total flavonoids[(17.2±1.9)μg quercetin equivalent/mg]contents.Antioxidant assays indicated that ethanol and methanol extracts possess potent antioxidant potential.Moreover,it was observed that ethanol and hexane extracts have the potential to inhibit most of the tested multi-drug resistant bacterial strains while methanol,chloroform and hexane extracts could inhibit the growth of pathogenic fungal strains successfully.Among all the studied extracts,ethanolic extract showed highest cytotoxicity against MCF-7 cell line then Hep-2 and DU-145 cell lines by MTT assay with lowest IC50 of 47.3μg/m L.CONCLUSION:These results suggest that R.dentatus could be a potent alternative candidate for treatment of microbial infections and for breast cancer treatment. | Riffat Batool Ejaz Aziz Hina Salahuddin Javed Iqbal Saira Tabassum Tariq Mahmood | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 1 |
| 12 | Clinical efficacy of direct-acting antiviral therapy for recurrent hepatitis C virus infection after liver transplantation in patients with hepatocellular carcinoma显示文摘BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of transplantation.Direct-acting antiviral(DAA)therapy has been adopted as the standard of care for recurrent HCV infection in the post-transplant setting.However,there are insufficient data regarding its efficacy in liver transplant(LT)recipients with a history of hepatocellular carcinoma(HCC),and the risk of HCC recurrence after DAA therapy is unknown.predictors of DAA treatment failure and HCC recurrence in LT recipients.METHODS A total of 106 LT recipients given DAAs for recurrent HCV infection from 2015 to 2019 were identified(68 with and 38 without HCC).Descriptive statistics and logistic regression models were used to estimate the multivariate odds ratios and respective 95%confidence intervals for predictors of treatment failure and HCC recurrence.RESULTS Six patients(6%)experienced DAA therapy failure post-LT and 100(94%)had a sustained virologic response at follow-up week 12.A high alanine transaminase level>35 U/L at treatment week 4 was a significant predictor of treatment failure.Relapse to pre-LT DAA therapy is a predictor of post-LT HCC recurrence,P=0.04.DAA relapse post-LT was also associated with post-transplantation HCC recurrence,P=0.05.CONCLUSION DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of HCC.Relapse to pre-and post-LT DAA therapy is associated with post-transplantation HCC recurrence. | Mohamed Saleh Ismail Manal Hassan Saira Aijaz Khaderi Wael Ahmed Yousry Maha Mohsen Kamal El-Din Mohamed Mohamed Bahaa El-Din Osama Aboelfotoh El Sayed Ahmed Omar Kaseb John Alan Goss FasihaKanwal Prasun Kumar Jalal | 2020 | World Journal of Hepatology2020，12，9： | 1 |
| 13 | Information System and Firms'Performance:the Case of Malaysian Small Medium Enterprises显示文摘 | Saira K Zariyawati M A | 2010 | International Business2010，3，4： | 1 |
| 14 | Field evaluation of Eimeria tenella (local isolates) gametocytes vaccine and its comparative efficacy with imported live vaccine, LivaCox?显示文摘 | M. Irfan Anwar Masood Akhtar Iftikhar Hussain A. U. Haq Faqir Muhammad M. Abdul Hafeez M. Shahid Mahmood Saira Bashir | 2008 | Parasitology Research2008，，1： | 1 |
| 15 | Hidden markov models in computational biology:applications to protein modeling显示文摘 | Anders Krogh Y Michael Brown Y I Saira Mian X | 1994 | Journal of Molecular Biology1994，235，： | 1 |
| 16 | Serous carcino-ma arising in endometrial polyps: clinicopathologic study of 4 cases显示文摘 | Romana Idrees Nasir Ud Din Saira Fatima | 2013 | Annals of Diagnostic Pathology2013，17，3： | 1 |
| 17 | Association of pro12ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy显示文摘 | Tariq Khadija Malik Saira Bano Ali Syeda Hafiza Benish | 2013 | Mol Vis2013，19，： | 1 |
| 18 | Congenital malaria显示文摘 | Emad S Saira L Seema H | 2008 | Pak J Med Sci2008，24，5： | 1 |
| 19 | Diagnostic utility of soluble fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy显示文摘 | Saira Salahuddin Young Lee Mary Vadnais Benjamin P. Sachs S. Ananth Karumanchi Kee-Hak Lim | 2007 | American Journal of Obstetrics and Gynecology2007，，1： | 1 |
| 20 | Elimination of cardiopulmonary bypass: a prime goal in reoperative coronary artery bypass surgery 1显示文摘 | Jacob Bergsland Saira Hasnain Thomas Z. Lajos Tomas A. Salerno | 1998 | European Journal of Cardio-Thoracic Surgery1998，，1： | 1 |
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