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| 1 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 2 | Hepatitis B virus genotypes in chronic liver disease patients from New Delhi,India显示文摘AIM: To study the Hepatitis B virus (HBV) genotypes and their effect on the progression and outcome in patients with chronic liver diseases from New Delhi, India. METHODS: Sera from 100 HBV-related chronic liver disease (CLDB) cases were tested for HBV genotype using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Type-specific primers-based PCR (TSP-PCR) targeting to the surface (S) gene encoding hepatitis B surface antigen. RESULTS: Only genotypes A and D were present and genotype D was dominant. Genotype D was present in all CLDB patient categories. The genotype distribution for the 100 patients with CLDB was as follows: genotype A, 16/100 (16%) (7/40- 17% chronic hepatitis B (CHB); 8/47, 17%, HBV-related cirrhosis (CRB); 1/13, 7.6%, HBV-related hepatocellular carcinoma (HCCB); genotype D- 84/100 (84%) (32/40- 80% CHB; 38/47- 81%, CRB; 11/13, 85%, HCCB); genotype A + D, 3/100 (3%) (1/40- 3% CHB; 1/47- 2%, CRB; 1/13, 7.6%, HCCB); C, 0; B, 0; E, 0; F, 0; G 0, H 0; (P < 0.01, genotype D vs A). CONCLUSION: Only HBV genotypes A and D were present in patients with CLDB from New Delhi, India. Compared with genotype D, genotype A patients had no significant clinical or biochemical differences (P > 0.05). Mixed infection with genotype A and D were seen in 3% of the cases. Genotype D was the dominant genotype prevalent in all patient categories. | Saket Chattopadhyay Bhudev Chandra Das Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，41： | 1 |
| 3 | Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum显示文摘 | Subash Chandra Mohapatra Hemandra Kumar Tiwari Manisha Singla Brijesh Rathi Arun Sharma Kuldeep Mahiya Mukesh Kumar Saket Sinha Shyam Singh Chauhan | 2010 | JBIC Journal of Biological Inorganic Chemistry2010，，3： | 1 |
| 4 | Laparoscopic ventral mesh rectopexy for complete rectal prolapse: A retrospective study evaluating outcomes in North Indian population显示文摘AIM: To analyze the outcomes of laparoscopic ventral mesh rectopexy in the management of complete rectal prolapse(CRP) in North Indian patients with inherent bulky and redundant colon. METHODS: The study was conducted at a tertiary health care center of North India. Between January 2010 and October 2014, 15 patients who underwent laparoscopic ventral mesh repair for CRP, were evaluated in the present study. Perioperative outcomes, improvement in bowel dysfunction or appearance of new complications were documented from the hospital records maintained prospectively. RESULTS: Fifteen patients(9 female) with a median age of 50 years(range, 15-68) were included in the study. The median operative time was 200 min(range, 180-350 min) and the median post-operative stay was 4 d(range, 3-21 d). No operative mortality occurred. One patient with inadvertent small bowel injury required laparotomy on post-operative day 2. At a median follow-up of 22 mo(range, 4-54 mo), no prolapse recurrence was reported. No mesh-related complication was encountered. Wexner constipation score improved significantly from the preoperative value of 17(range, 5-24) to 6(range, 0-23)(P < 0.001) and the fecal incontinence severity index score from 24(range, 0-53)to 2(range, 0-53)(P = 0.007). No de novo constipation or fecal incontinence was recorded during the followup. On personal conversation, all patients expressed satisfaction with the outcome of their treatment. CONCLUSION: Our experience indicates that laparoscopic ventral mesh rectopexy is an effective surgical option for CRP in North Indian patients having a bulky redundant colon. | Abhijit Chandra Saket Kumar Ajeet Pratap Maurya Vishal Gupta Vivek Gupta Rahul | 2016 | World Journal of Gastrointestinal Surgery2016，8，4： | 1 |
| 5 | Evolution of the MLO gene families in octoploid strawberry(Fragaria×ananassa)and progenitor diploid species identified potential genes for strawberry powdery mildew resistance显示文摘Powdery mildew(PM)caused by Podosphaera aphanis is a major fungal disease of cultivated strawberry.Mildew Resistance Locus O(MLO)is a gene family described for having conserved seven-transmembrane domains.Induced loss-of-function in specific MLO genes can confer durable and broad resistance against PM pathogens.However,the genomic structure and potential role of MLO genes for PM resistance have not been characterized yet in the octoploid cultivated strawberry.In the present study,MLO gene families were characterized in four diploid progenitor species(Fragaria vesca,F.iinumae,F.viridis,and F.nipponica)and octoploid cultivated(Fragaria×ananassa)strawberry,and potential sources of MLO-mediated susceptibility were identified.Twenty MLO sequences were identified in F.vesca and 68 identified in F.×ananassa.Phylogenetic analysis divided diploid and octoploid strawberry MLO genes into eight different clades,in which three FveMLO(MLO10,MLO17,and MLO20)and their twelve orthologs of FaMLO were grouped together with functionally characterized MLO genes conferring PM susceptibility.Copy number variations revealed differences in MLO composition among homoeologous chromosomes,supporting the distinct origin of each subgenome during the evolution of octoploid strawberry.Dissecting genomic sequence and structural variations in candidate FaMLO genes revealed their potential role associated with genetic controls and functionality in strawberry against PM pathogen.Furthermore,the gene expression profiling and RNAi silencing of putative FaMLO genes in response to the pathogen indicate the function in PM resistance.These results are a critical first step in understanding the function of strawberry MLO genes and will facilitate further genetic studies of PM resistance in cultivated strawberry. | Ronald R.Tapia Christopher R.Barbey Saket Chandra Kevin M.Folta Vance M.Whitaker Seonghee Lee | 2021 | Horticulture Research2021，8，1： | 1 |
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