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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | ZD1839,a selective epidermal growth factor receptor tyrosine kinase inhibitor,shows antimetastatic activity using a hepatocellular carcinoma model显示文摘 | Matsuo M Sakurai H Saiki I | 2003 | Mol Cancer Ther2003，2，： | 1 |
| 3 | A comparative study of biapenem and imipenem/cilastatin in lower respiratory infections 显示文摘 | Matsumoto F Inoue M Sakurai I | 2000 | Jpn J Chemother2000，48，1： | 1 |
| 4 | Negative inotropic effects of angiotensin Ⅱ, endothelin-1 and phenylephrine in indo-1 loaded adult mouse ventricular myocytes 显示文摘 | Sakurai K Norota I Tanaka H | 2002 | Life Sci2002，70，10： | 1 |
| 5 | Aminoglycosides prevent and dissociate the aggregation of platelets in patients with EDTA-de- pendent pseudothrombocytopenia 显示文摘 | Sakurai S Shiojima I Tanigawa T | | Br J Haematol0，99，4： | 1 |
| 6 | Questionnaire-based risk assessment scheme for Japanese offshore software outsourcing显示文摘 | Tsuji H Sakurai A Yoshida K I Tiwana A Bush A | 2007 | Computer Science2007，4716，： | 1 |
| 7 | Infection by Strepto- coceas pyogenes induces the receptor activator of NF - kappaB lig - and expression in mouse osteoblastic cells显示文摘 | Okahashi N Sakurai A Nakagawa I | 2003 | Infect Immun2003，71，2： | 1 |
| 8 | Hand-assisted laparoscopic function-preserving and radical gastrectomies for advanced-stage proximal gastric cancer显示文摘 | Uyama I Sugioka A Sakurai Y | 2004 | J Am Coll Surg2004，199，3： | 1 |
| 9 | Increased expression of integrin alpha3betal in highly brain metastatic subelone of a human non-small cell lung cancer cell line显示文摘 | Yoshimasu T Sakurai T Oura S Hirai I Tanino H Kokawa Y | 2004 | Cancer Sci2004，95，： | 1 |
| 10 | Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomas显示文摘 | Yang Q Sakurai T Mori I | 2001 | Cancer2001，92，1： | 1 |
| 11 | Movement and Orientation of the Japanese Scallop Patinopecten Yessoensis (Jay) in Response to Water Flow显示文摘 | SAKURAI I L SETO M | 2000 | Aquaculture2000，181，： | 1 |
| 12 | Influence of number and inclination angle of implants on stress distribution in mandibular cortical bone with All-on-4 Concept 显示文摘 | Takahashi T Shimamura I Sakurai K | 2010 | J Prosthodont Res2010，54，4： | 1 |
| 13 | Amlnoglycosides pre- vent and dissociate the aggregation of platelets in patients with EDTA dependent pseudothrombocytopenia 显示文摘 | Sakurai S Shiljima I Tanigawa T | 2013 | Br J Haematol2013，99，5： | 1 |
| 14 | Effectiveness of BNCT for recurrent head and neck malignancies显示文摘 | KATO I ONO K SAKURAI Y | 2004 | Applied Radiation and Isotopes2004，61，5： | 1 |
| 15 | The advances of laparoscopic treatment for gastric cancer显示文摘 | Uyama I Sakurai Y Komori Y | 2007 | Gan to Kagaku Ryoho2007，34，1： | 1 |
| 16 | Aminoglyeosides prevent and dissociate the aggregation of platelets with EDTA-dependent pseudothrombocytopenia显示文摘 | Sakurai S Shiojima I Tanigawa T | 1997 | Br J Haematol1997，99，4： | 1 |
| 17 | Aminoglycosides prevent and dissociate the aggregation of platelets inpatients with EDTAdependent pseudothrombocytopenia显示文摘 | Sakurai S Shiojima I Tanigawa T | 1997 | Br J Haematol1997，99，4： | 1 |
| 18 | Delayed leukoence phalop-athy after carbon monoxide poisoning presenting as subacute dementia显示文摘 | Mizuno Y Sakurai Y Sugimoto I | 2014 | Intern Med2014，53，13： | 1 |
| 19 | Lapamscopy-assisted uncut roux-en-y operation after distal gastrectomy for gastric: cancer 显示文摘 | Uyama I Sakurai Y Komori Y | 2005 | Gastric cancer2005，8，4： | 1 |
| 20 | 妊娠期饮酒与妊娠期高血压疾病的关系:日本环境与儿童研究显示文摘该研究在日本环境和儿童研究中调查了母亲孕期饮酒与妊娠期高血压疾病的关系。这是一项全国范围的出生队列研究,共有76940名孕妇被纳入分析。使用两份问卷获得有关怀孕期间饮酒量的信息:T1和T2。T1和T2问卷的平均孕龄分别为(16.5±5.8)和(27.9±3.7)周。饮酒作为暴露,妊娠高血压疾病作为结果,并将可能的混杂因素纳入具有logit连接功能的广义线性混合效应模型中。 | 刘青 叶鹏 Iwama N Metoki H Nishigori H Mizuno S Takahashi F Tanaka K Watanabe Z Saito M Sakurai K Ishikuro M Obara T Tatsuta N Nishijima I Sugiyama T Fujiwara I Kuriyama S Arima T Nakai K Yaegashi N | 2018 | 中华高血压杂志2018，26，11： | 1 |
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