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| 1 | Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma显示文摘AIM: To characterise expression of known E-cadherin repressors; Snail, Slug and Twist in the development of esophageal adenocarcinoma. METHODS: E-cadherin, Slug, Snail and Twist mRNA expression in Barrett's metaplasia and esophageal adenocarcinoma specimens was examined by real-time reverse transcription-polymerase chain reaction (RT-PCR). Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein levels. The effect of Slug on epithelial mesenchymal transition (EMT) markers was examined by transfection of Slug into an adenocarcinoma line OE33.RESULTS: Cellular localisation of Slug in Barrett's metaplasia was largely cytoplasmic whilst in adenocarcinoma it was nuclear. Semi-quantitative analysis indicated that Slug was more abundant in adenocarcinoma compared to matched Barrett's metaplastic specimens. Snail and Twist were expressed in adenocarcinoma but were cytoplasmic in location and not induced compared to Barrett's mucosa. These observations were supported by mRNA studies where only Slug mRNA was shown to be over-expressed in adenocarcinoma and inversely correlated to E-cadherin expression. Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin.CONCLUSION: Progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing. | Paras Jethwa Mushal Naqvi Robert G Hardy Neil A Hotchin Sally Roberts Robert Spychal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，7： | 24 |
| 2 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response显示文摘像使用费的受体(TLR ) 7 和 8 在对搁浅单人赛的 RNA (ssRNA ) 病毒的主人防卫是关键的。如此的病毒引起严重的病,它在 industrialised 和发展中的国家仍然是严肃的医药负担。下游地发信号的 TLR7/8 导致与精力消费联系的一个戏剧的细胞的压力。然而,到 TLR7/8-induced 应力的房间幸存和改编的分子的机制,给房间一个机会开始合适的煽动性的反应,根本不是清楚的。这里,我们第一次报导 TLR7/8 的导致 ligand 的激活导致组织缺氧可诱导的因素的累积 1 alpha (在经由氧化还原作用的 THP-1 人的 myeloid 巨噬细胞的 HIF-1 伪) 蛋白质 -- 并且反应的氮种类依赖者机制。地图 kinases 和 phosphoinositol-3K 不涉及 TLR7/8-mediated HIF-1 伪累积。有击倒的 THP-1 房间清楚地表明了的 HIF-1 伪的实验那 HIF-1 伪为对 ATP 的 TLR7/8-induced 弄空的这些房间的保护是重要的。因此, HIF-1 伪可能在 TLR7/8 激活之上支持房间幸存和支持 inflammatory cytokines 的生产。 | Sally A Nicholas Vadim V Sumbayev | 2009 | Cell Research2009，19，8： | 2 |
| 5 | Polyp detection rates using magnification with narrow band imaging and white light显示文摘AIM: To compare the yield of adenomas between narrow band imaging and white light when using high definition/magnification. METHODS: This prospective, non-randomized comparative study was performed at the endoscopy unit of veteran affairs medical center in Phoenix, Arizona. Consecutive patients undergoing first average risk colorectal cancer screening colonoscopy were selected. Two experienced gastroenterologists performed all the procedures that were blinded to each other's findings. Demographic details were recorded. Data are presented as mean ± SEM. Proportional data were compared using the χ2 test and means were compared using the Student's t test. Tandem colonoscopy was performed in a sequential and segmental fashion using one of 3 strategies: white light followed by narrow band imaging [Group A: white light(WL) → narrow band imaging(NBI)]; narrow band imaging followed by white light(Group B: NBI → WL) and, white light followed by white light(Group C: WL → WL). Detection rate of missed polyps and adenomas were evaluated in all three groups. RESULTS: Three hundred patients were studied(100 in each Group). Although the total time for the colonoscopy was similar in the 3 groups(23.8 ± 0.7, 22.2 ± 0.5 and 24.1 ± 0.7 min for Groups A, B and C, respectively), it reached statistical significance between Groups B and C(P < 0.05). The cecal intubation time in Groups B and C was longer than for Group A(6.5 ± 0.4 min and 6.5 ± 0.4 min vs 4.9 ± 0.3 min; P < 0.05). The withdrawal time for Groups A and C was longer than Group B(18.9 ± 0.7 min and 17.6 ± 0.6min vs 15.7 ± 0.4 min; P < 0.05). Overall miss rate for polyps and adenomas detected in three groups during the second look was 18% and 17%, respectively(P = NS). Detection rate for polyps and adenomas after first look with white light was similar irrespective of the light used during the second look(WL → WL: 13.7% for polyps, 12.6% for adenomas; WL → NBI: 14.2% for polyps, 11.3% for adenomas). Miss rate of polyps and adenomas however was significantly higher when NBI was used first(29.3% and 30.3%, respectively; P < 0.05). Most missed adenomas were ≤ 5 mm in size. There was only one advanced neoplasia(defined by size only) missed during the first look. CONCLUSION: Our data suggest that the tandem nature of the procedure rather than the optical techniques was associated with the detection of additional polyps' and adenomas. | Nooman Gilani Sally Stipho James D Panetta Sorin Petre Michele A Young Francisco C Ramirez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 2 |
| 6 | Toward a better understanding of the influences on physical ac- tivity: The role of determinants, correlates, causal variables, mediators,moderators, and confounders显示文摘 | BAUMAN A E SALLIS J F DZEWALTOWSKI D A | 2002 | Am J Prey Med2002，23，2： | 1 |
| 7 | Effect of injected Alzheimerβ-amyloid cores in rat brain 显示文摘 | Sally A Frautschy Andrew Baird | 1991 | Proc Natl Sci USA1991，，88： | 1 |
| 8 | Associations of Location and Perceived Environmental Attributes with Walking in Neighborhoods显示文摘 | Humpel N Owen N Leslie E Marshall A L Bauman A E Sallis J F | 2004 | American Journal of Health Promotion2004，18，3： | 1 |
| 9 | Neighborhood Environments and Physical Activity Among Adults in 11 Countries显示文摘 | Sallis J F Bowles H R Bauman A | 2009 | American Journal of Preventive Medicine2009，36，6： | 1 |
| 10 | Developing an Institutional Knowledge Bank at Ohio State University:From Concept to Action Plan显示文摘 | Sally A Rogers | 2003 | Libraries and Academy2003，3，1： | 1 |
| 11 | Identification of changes in gene expression in dorsal root ganglia in diabetic neuropathy:correlation with functional deficits显示文摘 | Sally A P Leo A H Z Leanne W | 2006 | J Neuropathol Exp Neurol2006，65，： | 1 |
| 12 | Useof hospital beds : a cohort study of admissions to a provincial teaching hospital 显示文摘 | A Peter M Jill B Sally | 1988 | BMJ1988，297，8： | 1 |
| 13 | A new methodology for the estimation of biomass of conifer-dominated boreal forest using NOAA AVHRR data显示文摘 | Hame T Salli A Andersson K | 1997 | Remote Sensing1997，18，15： | 1 |
| 14 | Emerging breastcancer epidemic:evidence from Africa显示文摘 | Sally N A Temidayo O Clement A | 2010 | Breast Cancer Res2010，12，4： | 1 |
| 15 | Correlates of physical activity:Why are some people physically active and others not?显示文摘 | Bauman A E Reis R S Sallis J F | 2012 | Lancet2012，380，： | 1 |
| 16 | Thiophesphinic acids as selective extractants for molybdenum recovery from a low grade ore and spent catalysts显示文摘 | SALLY A KHURANA U YADAV S K | 1996 | Hydrometallurgy1996，41，1： | 1 |
| 17 | How to investigate and analyse clinical incidents: clinical risk unit and association of litigation and risk management protocol显示文摘 | Charles V Sally T A Jane E C et ol | 2000 | BMJ2000，320，： | 1 |
| 18 | Moisture migration during freeze and thaw of unsaturated soils: Modeling and large scale experiments 显示文摘 | Shoop Sally A Bigl Susan R | 1997 | Cold Regions Science and Technology1997，25，1： | 1 |
| 19 | Localized Con- tent-based Image Retrieval 显示文摘 | Rouhollah R Sally A Zhang H | 2008 | Transactions on Pat- tern Analysis and Machine Intelligence2008，30，11： | 1 |
| 20 | Effects of early childhood psychosocial stimulation and nutritional supplementation on cognition and education in growth-stunted Jamaican children: prospective cohort study显示文摘 | Susan P Walker Susan M Chang Christine A Powell Sally M Grantham-McGregor | 2005 | The Lancet2005，，9499： | 1 |
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