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| 1 | Tumor necrosis factor-alpha induces apoptosis of enterocytes in mice with fulminant hepatic failure显示文摘AIM: To explore the alterations of intestinal mucosa morphology, and the effects of tumor necrosis factor α (TNFα) on enterocyte apoptosis in mice with fulminant hepatic failure (FHF).METHODS: Liver damage was induced by lipopolysaccharide(LPS)/TNF-α in D-galactosamine (GalN) sensitized BALB/c mice. There were 40 mice in normal saline (NS)-treated group, 40 mice in LPS-treatedl group, 40 mice in GaiN-treated group, 120 mice in GalN/LPS-treated group and 120 mice in GalN/TNFα-treated group. Each group was divided into five subgroups of eight mice each. Serum samples and liver, intestinal tissues were respectively obtained at 2, 6, 9, 12 and 24 h after administration. Anti-TNFα monoclonal antibody was injected intravenously into GalN/LPS-treated mice. Serum TNFα levels were determined by enzymelinked immunosorbent assays (ELISA). Serum ALT levels were determined using an automatic analyzer. The intestinal tissues were studied under light microscope and electron microscope at 2, 6, 9, 12 and 24 h in mice with fulminant hepatic failure, respectively. Enterocyte apoptosis was determined by terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) method. The expression of tumor necrosis factor receptor 1 (TNFR1) in intestinal tissue was tested by immunohistochemistry Envision Two Steps.RESULTS: Gut mucosa was morphologically normal at all time points in all groups, but typical apoptotic cells could be seen in all experimental groups under electron microscope. Apoptosis rate of gut mucosal epithelial cells were significantly increased at 6, 9 and 12 h, peaked at 12 h in mice with fulminant hepatic failure. TNFα induced apoptosis of enterocytes in mice with FHF. The integrated OD (IOD) levels of TNFα receptor 1 protein expressed in the intestine of mice with GalN/LPS and GalN/TNFαinduced FHF at 2, 6, 9, 12 and 24 h after GalN/LPS and GalN/TNFα administration were 169.54±52.62/905.79±111.84, 11 350.67±2 133.26/28 160.37±4 601.67, 25 781.00 ±2 277.75/122 352.30±49 412.40, 5 241.53±3 007.24/49 157.93±9 804.88, 7 086.13±1 031.15/3 283.45±127.67,respectively, compared with those in control groups (with NS, LPS and GalN administration, respectively). IOD level of TNFR1 changed significantly at 6, 9 and 12 h after GalN/LPS and GalN/TNFα administration. The expression of TNFR1 protein was significantly higher at g h after GalN/LPS and GalN/TNFα administration than that in control groups. Protein expression of TNFR1 was positively correlated with enterocyte apoptosis. CONCLUSION: TNFα can induce apoptosis of enterocytes in mice with FHF. Anti-TNFα IgG can inhibit this role. | Hong-LiSong SaLu PeiLiu | 2005 | World Journal of Gastroenterology2005，11，24： | 5 |
| 2 | Normalization of generalized retinal function and progression of maculopathy after cessation of therapy in a case of severe hydroxychloroquine retinopathy with 19 years follow-up显示文摘 | Salu P Uvijls A Van Den Brande P | 2010 | Doc Ophthalmol2010，120，3： | 1 |
| 3 | An improved method for localizing electric brain dipoles 显示文摘 | COHEN L G ROSE D | 1990 | IEEE Trans on Biomedical Engineering1990，37，7： | 1 |
| 4 | An improved methed for localizing elctric brain dipole显示文摘 | SALU Y COHEN L G ROSE D | 1990 | IEEE Trans Biomed Eng1990，37，7： | 1 |
| 5 | Use of a tacrolimus-eluting stent to inhibit neointimal hyperplasia in a porcine coronary model显示文摘 | Huang Y Salu K Wang L | 2005 | J Invasive Cardiol2005，17，3： | 1 |
| 6 | An improved method for localizing electric brain dipoles 显示文摘 | Salu Y Cohen L G Rose D | 1990 | IEEE Transactions on Biomedical Engineering1990，37，7： | 1 |
| 7 | Cyste- ine(C) - x - C receptor 4 undergoes transportin 1 - dependent nuclear localization and remains functional at the nucleus of meta- static prostate cancer cells 显示文摘 | Don - Salu - Hewage AS Chan SY Mcandrews KM | 2013 | PLoS One2013，8，57： | 1 |
| 8 | An improved method for localizing electric brain dipole显示文摘 | SALU Y COHEN L G ROSE D | 1990 | IEEE Trans Biomed Eng1990，37，7： | 1 |
| 9 | Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man显示文摘 | Alexander Jais Elisa Einwallner Omar Sharif Klaus Gossens Tess Tsai-Hsiu Lu Selma M. Soyal David Medgyesi Daniel Neureiter Jamile Paier-Pourani Kevin Dalgaard J. Catharina Duvigneau Josefine Lindroos Christensen Thea-Christin Zapf Sabine Amann Simona Salu | 2014 | Cell2014，，： | 1 |
| 10 | Co-dominant SCAR markers for detection of the Ty-3 and Ty-3a loci from Solanum chilense at 25 cM of chromosome 6 of tomato显示文摘 | JI Y SALUS M VAN BETTERAY B | | 0，，： | 1 |
| 11 | Selective Clearance of Macrophages in Atherosclerotic Plaques by Autophagy显示文摘 | Stefan Verheye Wim Martinet Mark M. Kockx Michiel W.M. Knaapen Koen Salu Jean-Pierre Timmermans Jeffrey T. Ellis Deborah L. Kilpatrick Guido R.Y. De Meyer | 2007 | Journal of the American College of Cardiology2007，，6： | 1 |
| 12 | An improved method for localizing electric brain dipoles显示文摘 | Salu Y Cohen LG Rose D | 1990 | IEEE Trans BME1990，37，7： | 1 |
| 13 | Risk factors for ab- dominal wound dehiscence in children: a ease control study 显示文摘 | Van Ramshorst GH Salu NE Bax NM | 2009 | World J Surg2009，33，7： | 1 |
| 14 | Co-dominant SCAR markers for detection of the Ty-3 and Ty-3a loci from Solanum chilense at 25 cM of chromosome 6 of tomato显示文摘 | JI Y SALUS M S SMEETS J | 2007 | Report of the Tomato Genetics Cooperative2007，57，： | 1 |
| 15 | Methotrexate loaded SAE coated coronary stents reduce neointimal hyperplasia in a porcine coronary model显示文摘 | Huang Y Salu K Li S | 2004 | Heart2004，90，2： | 1 |
| 16 | Stent-mediated methylprednisolone delivery reduces macrophage contents and in-stent neointimal formation显示文摘 | Wang L Salu K Verbeken E | 2005 | Coron Artery Dis2005，6，4： | 1 |
| 17 | Non-consensus heptamer sequences destabilize the RAG post-cleavage complex,making ends available to alternative DNA repair pathways显示文摘 | Arnal S M Holub A J Salus S S | 2010 | Nucleic Acids Res2010，38，9： | 1 |
| 18 | Salt sensitivity and the activities of the H* -ATPases in cotton seedlings 显示文摘 | Lin H Salus S S Schumaker K S | 1997 | Crop Sci1997，37，： | 1 |
| 19 | An improved method for localizing electric brain dipoles 显示文摘 | Salu Y Cohen L G Rose D | 1990 | IEEE Transactions on Biomedical Engineering1990，37，7： | 1 |
| 20 | Use of a tacrolimus -elutingstent to inhibit neointimal hyperplasia in a porcine coro-nary model 显示文摘 | Huang Y Salu K Wang L | 2005 | The Journal of invasive cardiology2005，17，3： | 1 |
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