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| 1 | Risk factors, surgical complications and graft survival in liver transplant recipients with early allograft dysfunction显示文摘Background: Early allograft dysfunction (EAD) is a severe complication after liver transplantation. The associated risk factors and complications have re-gained recent interest. This study investigated risk factors, survival and complications associated with EAD in a large liver transplant center in Latin America. Methods: Retrospective, unicenter, cohort, based on data from adult patients undergoing first deceaseddonor liver transplant from January 2009 to December 2013. EAD was defined by one or more of the following:(i) bilirubin ≥10 mg/dL on postoperative day 7;(ii) international normalized ratio ≥1.6 on postoperative day 7, and (iii) alanine aminotransferase or aspartate aminotransferase > 2000 IU/L within the first seven days after transplant. Results: A total of 602 patients were included;of these 34.2% developed EAD. Donor risk factors were male ( P = 0.007), age between 50 and 59 years ( P = 0.034), overweight ( P = 0.028) or grade I obesity ( P = 0.012), sodium > 157 mmol/L ( P = 0.002) and grade IV ischemia/reperfusion injury ( P = 0.002). Cold ischemia time ≥10 h ( P = 0.008) and warm ischemia time ≥40 min ( P = 0.013) were the surgical factors. Male ( P < 0.001) was the only recipient protective factor. Compared with the non-EAD group, patients with EAD were submitted to more reoperations (24.3% vs. 13.4%, P = 0.001) and had higher graft loss rates (37.9% vs. 21.2%, P < 0.001), with similar patient survival rates ( P = 0.238). Conclusions: EAD risk factors are related to donor, surgical procedure and recipient. Donor risk factors for EAD were male, age between 50 and 59 years, donor overweight or grade Ⅰ obesity, sodium > 157 mmol/L and grade Ⅳ ischemia/reperfusion injury. Cold ischemia time ≥10 h and warm ischemia time ≥40 min were the surgical risk factors. Male was the only recipient protective factor. Patients with EAD had higher reoperations and graft loss rates. | Douglas Bastos-Neves Paolo Rogerio de Oliveira Salvalaggio Marcio Dias de Almeida | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 15 |
| 2 | Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring显示文摘It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear. | Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 3 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 4 | Cutting edge: Transplantation tolerance through enhanced CTLA4 expression 显示文摘 | Ariyan C Salvalaggio P Fecteau S | 2003 | J Immunol2003，171，11： | 1 |
| 5 | Increasing incidence of new-onset diabetes after transplant among pediatric renal transplant patients显示文摘 | Burroughs TE Swindle JP Salvalaggio PR | 2009 | Transplantation2009，88，3： | 1 |
| 6 | Liver graft volume estimation in 100 living donors:measure twice,cut once显示文摘 | Salvalaggio P Baker T Koffron A | 2005 | Transplantation2005，80，： | 1 |
| 7 | Liver graft volume estimation in 100 living donors: Measure twice, cut once显示文摘 | Salvalaggio PR Baker TB Koffron AJ | 2005 | Transplantation2005，80，9： | 1 |
| 8 | Oral glutamine doesnot prevent bacterial translocation in rats subjected to intestinal obstruction and Escherichia coli challenge but reduces systemic bacteria spread显示文摘 | Salvalaggio PR Neto CZ Tolazzi AR | 2002 | Nutrition2002，18，4： | 1 |
| 9 | Islet filtration: a simple and rapid new purification procedure that avoids ficoll and improves islet mass and function 显示文摘 | Salvalaggio PR Deng S Ariyan CE | 2002 | Transplantation2002，74，6： | 1 |
| 10 | Hepatocellular car- cinoma recurrence among liver transplant recipients within the milan criteria显示文摘 | Felga G Evangelista A S Salvalaggio P R | 2012 | Transplant Proc2012，44，8： | 1 |
| 11 | Phenological patterns among plant life-forms in a subtropical forest in southern Brazil显示文摘 | Márcia C. M. Marques James J. Roper Ana Paula Baggio Salvalaggio | 2004 | Plant Ecology2004，，2： | 1 |
| 12 | Laparoscopic donor nephrectorny 1997 - 2002 :donor and recipient ourcomes in more than 400 cases at a single institution 显示文摘 | Kocak B Koffron A Salvalaggio P | 2003 | Am J Transplant Supplement2003，3，5： | 1 |
| 13 | Cutting edge:transplantation tolerance through enhanced CTLA-4 expression显示文摘 | Ariyan C Salvalaggio P Fecteau S | | 0，，11： | 1 |
| 14 | Outcomes and risk factors for failure of radiologic treatment of biliary strictures in pediatric liver transplantation recipients显示文摘 | Sunku B Salvalaggio PR Donaldson JS | 2006 | Liver Transpl2006，12，5： | 1 |
| 15 | Islet filtration: a simple and rapid new purification procedure that avoids ficoll and improves islet mass and function显示文摘 | Salvalaggio PR Deng S Ariyan CE | 2002 | Transplantation2002，74，6： | 1 |
| 16 | Immunosuppression for pancreas transplantation显示文摘 | Kaufman DB Salvalaggio PR | 2005 | Organ Transplant2005，10，： | 1 |
| 17 | Laparoscopic donor nephrectomy 1997 to 2003:lessons learned with 500 cases at a single institution 显示文摘 | Leventhal J R Kocak B Salvalaggio P R Koffron A J Baker T B Kaufman D B | 2004 | Surgery2004，136，： | 1 |
| 18 | Incremental value of the pancreas anograft to the survival of simultaneous pancreaskidney transplant recipients显示文摘 | Salvalaggio PR Dzebisashvili N Pinsky B et a1 | 2009 | Diabetes Care2009，32，： | 1 |
| 19 | Cutting edge: Transplantation tolerance through enhanced CTLA4 expression 显示文摘 | Ariyan C Salvalaggio P Fecteau S | 2003 | J Immunol2003，171，11： | 1 |
| 20 | Liver graft vol- ume estimation in 100 living donors: measure twice, cut once显示文摘 | Salvalaggio P R Baker T B Koffron A J | 2005 | Transplantation2005，80，9： | 1 |
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