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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease显示文摘AIM: To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classification.METHODS: In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared.RESULTS: Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively rs = 0.31, P < 0.01 and rs = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infliximab (93 % vs 33 %, P = 0.06).CONCLUSION: A higher CRP level during relapse seems to be associated with a more severe clinical course of disease. | Chantal L Koelewijn Matthijs P Schwartz Melvin Samsom Bas Oldenburg | 2008 | World Journal of Gastroenterology2008，14，1： | 4 |
| 3 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 4 | Treatment of severely delayed gastric emptying显示文摘 | Samsom M Gooszen HG | 2000 | Ned Tijdschr Geneeskd2000，144，41： | 1 |
| 5 | Direct cytolytic activity of PBMC from pigs infected with porcine reproductive and respiratory syndrome显示文摘 | Samsom J N Voermans J J M de Brin M G M | 2000 | Vet Res2000，31，： | 1 |
| 6 | Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus显示文摘 | M G M De Bruin Samsom J N | 2000 | Veterinary Immunology and Immunopathology2000，76，： | 1 |
| 7 | The effects of the specific 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers 显示文摘 | Schryver A Andriesse G Samsom M | 2002 | Aliment Pharmacol Ther2002，16，3： | 1 |
| 8 | Hyperglycemia Affects Gastric Electrical Rhythm and Nausea During Intraduodenal Triglyceride Infusion显示文摘 | Geoffrey S. Hebbard Melvin Samsom Jane M. Andrews David Carman Ben Tansell Wei Ming Sun John Dent Michael Horowitz | 1997 | Digestive Diseases and Sciences1997，，3： | 1 |
| 9 | Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: their mechanisms of action and role in the treatment of IBD显示文摘 | van Dieren JM Kuipers E J Samsom JN | 2006 | Inflamm Bowel Dis2006，12，4： | 1 |
| 10 | Hyperglycemia induces abnormalities of gastric myoelcctrical activity in patients with type I di- abetes mellitus显示文摘 | Jebbink RJ Samsom M Bruijs PP | 1994 | Gastroenterology1994，107，5： | 1 |
| 11 | Impact of Delayed Gastric Emptying on the Outcome of Antireflux Surgery显示文摘 | Janiek E. Bais Melvin Samsom Eldert A. J. Boudesteijn Peter P. van Rijk Louis M. A. Akkermans Hein G. Gooszen | 2001 | Annals of Surgery2001，，2： | 1 |
| 12 | The effects of the specific 5HT (4) receptor agonist,prucalopride,on colonic motility in healthy volunteers显示文摘 | De Schryver AM Andriesse GI Samsom M | | 0，，03： | 1 |
| 13 | The importance of regional lymph nodes for mucosal tolerance显示文摘 | Kraal G Samsom JN Mebius RE | 2006 | Immunol Rev2006，213，1： | 1 |
| 14 | Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type 1 diabetes mellitus显示文摘 | Jebbink RJ Samsom M Bruijs PP | 1994 | Gastroenterology1994，107，5： | 1 |
| 15 | Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus 显示文摘 | De Bruin M G M Samsom J N Voermans J J M | 2000 | Veterinary Immunology and Immunopathology2000，76，： | 1 |
| 16 | Local Immune Regulation of Mucosal Inflammation by Tacrolimus显示文摘 | Jolanda M. Dieren Margaretha E. H. Lambers Ernst J. Kuipers Janneke N. Samsom C. Janneke Woude Edward E. S. Nieuwenhuis | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 17 | Involvement of Bcl-2 family proteins in germ cell apoptosis during testicular development in the rat and pro-survival effect of stem cell factor on germ cells in vitro显示文摘 | Yan W Suominen J Samsom M | 2000 | Mol Cell Endocrinol2000，165，12： | 1 |
| 18 | Effects of a porcine reproductive and respiratory syndrome virus infection on the development of the immune response against pseudorabies virus 显示文摘 | De Bruin M G M Samsom J N Voennans J J M | 2000 | Veterinary Immunology and Immunopathology2000，76，： | 1 |
| 19 | Association between pain episodes and high amplitude propagated pressure waves in patients with irritable bowel syndrome显示文摘 | Clemens C H Samsom M Roelofs J M | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 20 | Relationships of upper gastrointestinal motor and sensory function with glycemic control显示文摘 | Rayner CK Samsom M Jones KL | 2001 | Diabetes Care2001，24，： | 1 |
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