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| 1 | The insulin-like growth factor 1 pathway is a potential therapeutic target for low-grade serous ovarian carcinoma显示文摘 | Erin R. King Zhifei Zu Yvonne T.M. Tsang Michael T. Deavers Anais Malpica Samuel C. Mok David M. Gershenson Kwong-Kwok Wong | 2011 | Gynecologic Oncology2011，，1： | 1 |
| 2 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 3 | ReVirt显示文摘 | George W. Dunlap Samuel T. King Sukru Cinar Murtaza A. Basrai Peter M. Chen | 2002 | ACM SIGOPS Operating Systems Review2002，，： | 1 |
| 4 | Re Virt: enabling intrusion analysis through virtual-machine logging and replay 显示文摘 | Dunlap George W Samuel T King | 2002 | ACM SIGOPS Operating Systems Review2002，36，： | 1 |
| 5 | Subvert Implementing Malware With Virtual Machines显示文摘 | Samuel T King Peter M Chen | | 0，，： | 1 |
| 6 | SubVirt Implementing Malware With Virtual Machines显示文摘 | Samuel T King Peter M Chen | 2006 | IEEE Symposium on Security and Privacy2006，，： | 1 |
| 7 | Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC显示文摘 | Augusto Caraceni Geoffrey Hanks Stein Kaasa Michael I Ben- nett Cirmia Brunelli Nathan Chemy Ola Dale Franco De Conno Marie Fallon Magdi Hanna Dagny Faksvfig Haugen Gitte Juhl Samuel King PadKlepstad Eivor A Laugsand Marco Maltoni Se- bastiano Mercadante Maria Nabal Alessandra Pigni Lukas Rad- bmch Colette Reid Per Sjogren Patrick C Stone Davide Tassi- nail Giovambattista Zeppetella | 2012 | Lancet Oncol2012，13，2： | 1 |
| 8 | The Anterior Gradient Homolog 3 (AGR3) Gene Is Associated With Differentiation and Survival in Ovarian Cancer显示文摘 | Erin R. King Celestine S. Tung Yvonne T.M. Tsang Zhifei Zu Gabriel T.M. Lok Michael T. Deavers Anais Malpica Judith K. Wolf Karen H. Lu Michael J. Birrer Samuel C. Mok David M. Gershenson Kwong-Kwok Wong | 2011 | The American Journal of Surgical Pathology2011，，： | 1 |
| 9 | ReVirt显示文摘 | George W. Dunlap Samuel T. King Sukru Cinar Murtaza A. Basrai Peter M. Chen | 2002 | ACM SIGOPS Operating Systems Review (SI)2002，，： | 1 |
| 10 | SubVirt Implementing MalwareW ithVirtualMachines显示文摘 | Samuel T King Peter M Chen | | 0，，： | 1 |
| 11 | β-Chitin/Chitosan Obtained from Loligo and Humboldt Squids Effectiveness as Wound Dressing Material显示文摘A number of materials are utilized to develop wound care dressing materials with metallic treatments such as ionic silver and zinc. Metallic ions if used for a prolonged time may lead to toxicity. Alternatively chitin,a natural polysaccharide found in nature, is utilized. It is found in fungi, crabs, mushrooms,squids, octopus, and many other living organisms. Chitin has similar structure to cellulose but its deacetylated derivate chitosan has amine groups that provide potential antibacterial properties along with a number of other advantages. Chitin in its natural form is found in three different structural forms,namely α,β,and γ.The β-chitin and chitosan are mostly found in the exoskeleton of squids. Loligo and Humboldt squids were studied. It is anticipated that Humboldt chitin is more effective in serving as antibacterial material and can be utilized for wound care. Differences in steriochemical structure were observed among β-chitin structures obtained and amine group's presences were found along with ability of materials to swell. | JINDAN Rahim ZALAL Rahim HUDSON Samuel KING W Martin | 2013 | Journal of Donghua University(English Edition)2013，30，5： | 0 |
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