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您的检索式：作者名="Sanjeev Ram"
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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients显示文摘Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell(CSC)population after 3 cycles of standard chemotherapy.The epigenetic response(miRNAs expression)and CSCs are also correlated in patients with Breast Cancer.In patients who tolerated chemotherapy well,miRNA-21(non-coding RNA)expression decreased significantly after three cycles of chemotherapy.The miRNA-21 expression in breast cancer tissue was quantified by quantitative PCR(real-time PCR)using the standard protocol.In addition,breast CSCs(CD44+/CD24-)were also decreased in these patients.The miRNA-21 regulates cell division,proliferation,and autophagy of cancerous cells(as it targets phosphatase and tensin homolog/AKT/transcription factor EB/programmed cell death 4/autophagy-related protein 5 and chemotherapy also produces similar effects),thereby contributing to these benefits.Therefore,when all of the targets on genes have been explored by mimic miRNA,chemotherapy combined with anti-miRNA21 therapy may prove useful in the care of cancer patients. | Shailendra Dwivedi Puneet Pareek Jeewan Ram Vishnoi Praveen Sharma Sanjeev Misra | 2022 | World Journal of Stem Cells2022，14，4： | 3 |
| 3 | Refiners have several options for reducing gasoline benzene显示文摘 | Alan R Goelzer Agustin Hernandez Robinson Sanjeev Ram | 1993 | J Oil Gas Journal1993，91，37： | 1 |
| 4 | 真菌在尼泊尔喜马拉雅地区基于生态系统的适应(EbA)实践中的作用评估显示文摘为了实现可持续发展目标(SDG),从而实现2020年后全球生物多样性目标并提高人类社会对气候变化的抵御能力,建议将基于生态系统的适应(EbA)等基于自然的方法作为一种有前途的综合适应战略。EbA包括重视生态系统在降低社会对气候变化的脆弱性方面的作用的适应战略。在地球上不同的生物群中,真菌不仅在维持生态系统中的生物地球化学循环/养分循环(支持和调节服务)方面发挥着重要作用,而且还为人类的社会经济和文化利益(供应和文化服务)做出了贡献。本文根据对冬虫夏草(Ophiocordyceps sinensis)和其他野生真菌的实地考察、相关文献回顾以及作者的相关专业知识,对这些生物多样性真菌群体如何对基于生态系统的适应(EbA)方法的知识的科学理解进行了介绍。在尼泊尔,很多当地社区将几种真菌用作食品、药品,真菌同时也是尼泊尔山区社区的重要家庭收入来源,可在灾难期间提供缓冲,并对粮食安全、医疗保健、教育等具有积极作用。对于综合EbA方法,应加强地方机构的管理以及本土(地方)知识的教育,以对生态、社会和经济有用的真菌物种的识别、保护和可持续管理进行适当的政策干预。 | DEVKOTA Shiva SHRESTHA Uttam Babu POUDEL Sanjeev CHAUDHARY Ram Prasad | 2022 | Journal of Resources and Ecology2022，13，6： | 0 |
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