|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 2 | Therapeutic effect of transcatheter arterial chemoembolization and percutaneous injection of acetic acids on primary liver cancer显示文摘BACKGROUND: The resection rate of primary liver tumor in China is only about 20%. A lot of patients with moderate and advanced liver tumor may lose the chance of opera- tion. The objective of present research was to study the ef- ficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous injection of chemical agents and acetic acids in the treatment of patients with primary liver cancer (PLC). METHODS: Thirty-three patients with middle and ad- vanced stage of PLC were divided into two groups: percu- taneous injection of chemical agents and acetic acids (15 patients, group A) and TACE (18 patients, group B). RESULTS: Tumor diameter and serum AFP level reduced to 86.6% and 83.3% in group A, and 55.5% and 40% in group B, respectively. There was significant difference be- tween the two groups ( P < 0 . 0 1 ) . The 1-, 2-, 3-, 4-year survival rates of group A were 96.7%, 86.6%, 51.3%, 33.3%, respectively and in group B were 66.7%, 44.4%, 16.7%, 0%, respectively (P<0.01). CONCLUSION: TACE combined with percutaneous injec- tion of chemical agents and acetic acids is efficacious to in- crease the survival rate of patients with PLC. | Hong-Bin Chen, Yue Huang, Dong-Ling Dai, Xia Zhang, Zhong-Wen Huang, Qi-Kai Zhang, Hui-Hua Wang, Jun-Su Zhang and Ge Pan Sanming, China Departments of Gastroenterology , Interventional Therapy , Ultrasonography and CT , Sanming Municipal First Hospital, Sanming 365000, China Department of Gastroenterology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 4 |
| 3 | Effect of slope inclination on step friction coefficient of human being显示文摘Effect of slope inclination on step friction coefficient of human being was studied by gait friction tester developed by Henan University of Science and Technology.It is beneficial to improving the safety of human beings while walking on a ramp.Based on the trajectory of mass center of body(MCOB)and the mechanical analysis of human body while walking,conclusion could be drawn that the required step frictional coefficient(RSFC)exhibited an'M'shaped curve during the foot contacting with the ground and got its maximum and minimum values when MCOB of the subject was at the highest and lowest position respectively.Moreover,the first peak of RSFC decreases firstly and then increases,while the second peak of RSFC increases with the increase of slope inclination at the experimental condition.The position of pivotal point is decided by the relative size of slope inclination and the angle between the plumb line through MCOB and the line from foot to MCOB. | ZHANG YongZhen JIA LiXiao PANG XianJuan NIU YongPing DU SanMing | 2013 | Science China(Technological Sciences)2013，56，12： | 3 |
| 4 | Influence of hydroxypropyl methylcellulose,methylcellulose, gelatin, poloxamer 407 and poloxamer 188 on the formation and stability of soybean oil-in-water emulsions显示文摘Macromolecules of polysaccharides, proteins and poloxamers have a hydrophobic portion and a hydrophilic one that can be used as emulsifiers. Parts of these emulsifiers are safe pharmaceutical excipients, which can replace the irritant low molecular weight surfactants to formulate emulsions for the pharmaceutical field. This project focused on preparing O/W emulsions stabilized with polymers for pharmaceuticals such as polysaccharides, proteins and poloxamers, including hydroxypropyl methylcellulose (HPMC), methylcellulose (MC),gelatin, poloxamer 407 (F127) and poloxamer 188 (F68). Emulsion physical stability was assessed by centrifugation, autoclaving sterilization and droplet size measurements. The stabilization mechanisms of emulsions were determined by interfacial tension and rheological measurements. Results stated that the efficacy of these polymers for pharmaceuticals stabilized emulsions was sorted in the order: F127 > F68 > HPMC > MC > Gelatin. | Miao Zhang Baixue Yang Wei Liu Sanming Li | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 2 |
| 5 | Study on Mineralization Age of Xiaoban Gold Deposit, Fujian Province显示文摘The Xiaoban gold deposit is a large size deposit recently found in middle area of Fujian Province. It belongs to magmatic hydrothermal type occurred in Mayuan Group metamorphic rocks of Middle Proterozoic and is controlled by low angle fault (detachment) structures. The contents of Au in Mayuan Group metamorphic rocks, Caledonian Indosinian deformed granite and early Yanshanian granite are higher with Au enrichment coefficient of 2.06-5.68, 5.11 and 6.67 than those in other geological bodies. And the higher enrichment coefficients (>2) of Ag, S, Sn and Te are similar to those of gold ore. Meanwhile, the distribution of Au in Mayuan Group metamorphic rocks and early Yanshanian granite with a low D value (0.58 and 0.67) is favorable to gold mineralization. REE characteristics of gold ore, ratios of (LREE/HREE), (La/Sm) n, (Yb/Lu) n, (La/Tb) n and (Sm/Nd) n are similar to Mayuan Group metamorphic rocks, only non or little normal Eu abnormal of ore is dissimilar to metamorphic rocks. The δ ( 34 S) of the gold ore, with a high homogenization, is (-4.7×10 -3 )-(-2.7×10 -3 ). The study of inclusion indicates 180-249 ℃ of mineralization temperature, 3.69 %-11.81 % of salinities and 0.869-0.991 g/cm 3 of densities of mineralization fluid. Based on hydrogen and oxygen isotope ( δ ( 18 O)=11.0×10 -3 -11.7×10 -3 , δ (D)=(-48×10 -3 )-(-62×10 -3 )) and initial w ( 87 Sr)/ w ( 86 Sr) =0.715,combining to the analysis of geological history, regional metamorphism and magamtic activity, the authors confirm that the source for the ore fluid was mainly from magmatic, partly from metamorphic water, and with a little influence of meteoric water. Isotopic dating made on Rb Sr isochron age of 182 Ma, by using alteration minerals of gold ores from the deposit, indicates that the mineralization occurs in early Yanshanian epoch. This is close to the age of 187 Ma of the Anchun magmatite with a similar alteration and gold mineralization to the Xiaoban gold deposit. The age of early Yanshanian epoch of the Xiaoban gold is indentical with the characteristics of southern China gold metallogenic belt and the geotectonic evolution of the transition from paleo Asian system and paleo Tethyan system to paleo Pacific active continental margin in eastern Asia. | Chen Bailin Institute of Geomechanics, CAGS, Beijing 100081 Wu Ganguo Faculty of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083 Zhang Da Institute of Geomechanics, CAGS, Beijing 100081 Huang Rensheng West Fujian Geological Party of FBGMRE, Sanming 365000 Wu Jianshe Fujian Bureau of Geological and Mineral Resources Exploration, Fuzhou 350003 | 2002 | Journal of China University of Geosciences2002，13，3： | 2 |
| 6 | Impact of material permeability on friction and wear Properties under the interference of DC steady magnetic field显示文摘 | Yonghui Wei Yongzhen Zhang Yue Chen Sanming Du | 2013 | Tribology International2013，，： | 1 |
| 7 | Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery显示文摘Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride(H-Leu-OMe·HCl).LMSNs were characterized by transmission electron microscopy(TEM),nitrogen adsorption/desorption,and small-angle X-ray diffraction(SAXRD),demonstrating a well-ordered mesostructure.After loading doxorubicin hydrochloride(Dox) into pores,considerable loading capacity of 30.5% and favorable cumulative release amount were obtained.MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor.The use of MSNs with the synthesized template,as a drug delivery carrier,will exte nd the pharmaceutical applications of silica materials. | Wei Zhang Qiming Kan Lu Chen Luyao Xie Mingshu Cui Ziyue Xi Yanru Xi Sanming Li Lu Xu | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 8 | Double-skin facades in the hot summer and cold winter zone in china:Cavity open or closed?显示文摘 | Guoqing He Lifang Shu Sanming Zhang | 2011 | Building Simulation2011，14，： | 1 |
| 9 | A SiGe BiCMOS Transmitter/Receiver Chipset With On-Chip SIW Antennas for Terahertz Applications显示文摘 | Hu Sanming Xiong Yongzhong Zhang Bo | | 0，，11： | 1 |
| 10 | The Making of English:A Story Of Three Invasions and A Cultural Revolution显示文摘How come the English language develops into whatwe now call Modern English?This article intends to find outsome of itsorigins and reasonsfrom the pointof wview ofthe historical backgrounds thatresults in the development. | Zhang Jingfeng (Departmentof English,Sanming Teachers College) | 2000 | 三明学院学报2000，18，3： | 1 |
| 11 | Synthesis and Charactrization of Liquid Crystalline Lomoners with Polymethylhydrosiloxane Main-chainand Side-chain-containing Sulfonic Acid Groups显示文摘 | Zhang Baoyan Guo Sanming Shao Bing | 1998 | Journal of Applied Polymer Science1998，68，5： | 1 |
| 12 | Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosisin A549 human lung cancer cells显示文摘 | Yachao Zhao Changliang Zhu Xiaofei Li Zhipei Zhang Yuan Yuan Yunfeng Ni Tonggang Liu Sanming Deng Jinbo Zhao Yunjie Wang | 2011 | Oncology Reports2011，，4： | 1 |
| 13 | Genetic Types, Spatiotemporal Distribution of Ore Deposits and Sources of Ore-forming Materials in the Xuancheng Area, Anhui Province显示文摘In recent years,several large and medium-sized ore deposits have been discovered in the shallow cover of Xuancheng,Anhui Province,indicating that this area has a productive metallogenic geological background and may be a potential prospecting region.Based on systematic investigation,the geological and mineralization characteristics of porphyry Cu-Au deposits and skarn Cu-Mo-W deposits in this region have been summarized.Zircon U-Pb dating(LA-ICPMS)of the Chating quartz-diorite porphyry and the Kunshan biotite pyroxene diorite yield concordia ages of 145.5±2.1 Ma and 131.8±2.1 Ma,respectively.Meanwhile,the Re-Os dating analyses for molybdenite from the Shizishan and Magushan skarn Cu-Mo deposits yielded 133.81±0.86 Ma and 143.8±1.4 Ma ages,respectively.When viewed in conjunction with previous studies,it is suggested that twostage(the early stage of 145-135 Ma and the late stage of 134-125 Ma)magmatism may have occurred during the Mesozoic in Xuancheng region.Early stage intrusive rocks are distributed along both sides of the Jiangnan deep fault(JDF).The intrusive rocks to the north of the JDF are mainly quartzdiorite porphyry and granodiorite(porphyry)rocks,related to porphyry Cu-Au deposits and skarn-type Cu-Mo-W deposits.These deposits belong to the first stage of the porphyry-skarn copper gold metallogenic belt of the Middle-Lower Yangtze Metallogenic Belt(MLYB),associated with the high potassium calc-alkaline intermediate-acid intrusions.The magmatic and ore-forming materials are mainly derived from the enriched lithospheric mantle.South of the JDF,the Magushan granodiorite is a representative intrusive rock of the first stage I-type granite,which hosts the Magushan Cu-Mo skarn deposit,similar to the W-Mo-Cu skarn deposits in the Eastern Segment of the Jiangnan Uplift Metallogenic Belt(ESJUB).The magmatic and metallogenic materials mainly came from the Neoproterozoic basement,with the possible participation of a small amount of mantle components.The late stage magmatism was dominated by volcanic rocks with a small amount of intrusive rocks,which were consistent with the limited volcanic-intrusive activities in the second stage of the MLYB.The H-O stable isotopes of ore deposits in the region indicate that the ore-forming hydrothermal fluids of the porphyry and skarn deposits were mostly of magmatic water for the ore-forming stage,the percentage of meteoric water obviously increasing during the late ore-forming stage.The ore-forming materials of the deposits are mainly from the deep magma with a few sedimentary wall rocks,according to the stable carbon isotopes of the carbonates in the ore deposits.Additionally,according to previous research,the molybdenite from the MLYB has a higher Re content than that of the ESJUB.The higher content of Re in the molybdenite from the Shizishan deposit is identical to that of MLYB rather than ESJUB,whereas Re characteristics in molybdenite of Magushan deposit are similar to that of ESJUB.The differences in Re characteristics indicate the different deep processes and ore-forming material sources(mainly mantle composition for the former and crustal materials for the latter)of these ore deposits on opposite sides of the JDF. | LU Sanming ZHANG Zanzan ZHAO Lili LI Jianshe ZHAO Zhuang QI Huasheng | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 1 |
| 14 | No Ideas But In Things—A study of 'The Revelation' by William Carlos Williams显示文摘This is the poet’s business. Not to talk in vague categories but to write particularly, as a physician works upona patient. upon the thing before him, in the particular to discover the universal. —— William carlos williams Taken as a subject matter, dreams are found both in conventional poems and in modernpoems. Undoubtedly, as everyone dreams in life,dreaming is part of our life experience. How- | Zhang Yanxue Sanming Teachers College | 1998 | 三明学院学报1998，16，3： | 0 |
| 15 | A 3D Investigation of Geological Structure and Its Relationship to Mineralization in the Nanling-Xuancheng Ore District,Middle-Lower Yangtze River Metallogenic Belt,China显示文摘The Nanling-Xuancheng ore region of Anhui Province is located in the Middle-Lower Yangtze River metallogenic belt.Insufficient exploration and research have been carried out in this newly defined ore district,although the Chating large porphyry Cu-Au deposit and a few middle-sized skarntype Cu polymetallic deposits have been discovered.In this study,we carried out high-resolution seismic reflection,magnetotelluric,gravity,and magnetic investigations,and constructed the 3 D geological structure of the uppermost crust in a depth range of 0-5 km using a comprehensive inversion of the new data constrained by previous deep-drilling data.We hence proposed some new insights to understand the mineralization processes of this district.A system of alternating ridges and valleys is suggested as the major structure pattern,composed of“two-layer structure”of the basins and“three-layer structure”of anticlines.Moreover,a conjugated fault system and its distribution features are revealed in our models,including the Jiangnan fault,Zhouwang fault,and Kunshan thrust nappe.The Jiangnan and Kunshan faults are suggested to have controlled the diagenesis and metallogenesis.Two deep concealed plutons located in Chating and Magushan are found,forming the Mesozoic diorite-felsic intrusions.These intrusions are believed to be the causes of hydrothermal deposits such as the Chating deposit and the Magushan deposit. | Sanming Lu Xueyi Lan Lili Zhao Zanzan Zhang Xiaoyong Yang Zhuang Zhao Dong Guo Xiaochun Xu Yongsheng Wang Jianshe Li Huasheng Qi | 2022 | Journal of Earth Science2022，33，3： | 0 |
| 16 | Research on cutting characteristics of fiber bundle with high-speed photography显示文摘Cutting is an essential and complicated process in many fields.Efficient and low-consumption cutting operations are of great significance for environmental protection and energy conservation.The development of high performance cutting parts relies on a deep understanding of the cutting process and cutting mechanism.In this research,a new type of cutting test bench with high-speed photography was developed,and the cutting tests were conducted on the jute fiber bundle from quasi-static cutting at 10 mm/s to dynamic cutting in the speed range of 0.6-2.4 m/s.The cutting process was captured by a high-speed camera.Analysis shows that compression exists before quasi-static cutting,and the compression force curve with respect to the compression ratio follows an exponential function.The cutting speed has a significant effect on cutting energy.The cutting energy consumption is not a monotonous function of cutting speed owing to the combined effect of elastic deformation and friction of fibers.The cutting energy increases with increasing cutting speed in the range of 0.6-1.2 m/s due to the increase of the friction within fibers and the friction between the blade and fibers.The cutting energy decreases with increasing cutting speed in the range of 1.2-1.8 m/s,and tends to be a fixed value when the cutting speed exceeds 1.8 m/s due to the stabilized elastic deformation and friction coefficient.From the perspective of energy saving,it is meaningless to increase the blade speed excessively when cutting fiber bundles. | Zhitao He Huiling Ding Sanming Du Zhen Li Jiangtao Ji Jian Li Yongzhen Zhang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，3： | 0 |
| 17 | Global plate motion and earthquake activity显示文摘全球板运动率不是在时空的制服。旋转率比 0.545 大 ?畦 n ???? | Yanxing Li Xiwu Luan Yuanzhong Lu Jinghua Zhang Hong Liu Sanming Luo Feng Liu | 2010 | Geodesy and Geodynamics2010，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员