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| 1 | 选区激光熔化和传统粉末冶金法制备Cu−Al−Ni−Mn−Zr形状记忆合金的对比显示文摘研究和分析选区激光熔化(SLM)与传统粉末冶金(PM)法制备Cu−11.3Al−3.2Ni−3.0Mn−0.5Zr形状记忆合金的显微组织特征和热稳定性差异。PM样品是将106~180μm预合金粉末在氩气气氛、1060℃下烧结制备的,无辅助加工,SLM样品是在Cu−10Sn基板上熔化32~106μm的预合金粉末制备的。通过维氏硬度试验评价材料的力学性能,采用差示扫描量热法测定马氏体相变温度,采用X射线衍射谱鉴定相成分,利用光学显微镜和扫描电子显微镜分析显微组织特征。结果表明,两种方法制备的合金中均发现β′1马氏体相,而在PM样品中存在粗大的马氏体变体。传统的粉末冶金样品在室温下会形成晶间共析成分和稳定的奥氏体。PM样品具有与SLM样品相似的平均硬度值,而与孔隙率相关的标准偏差较高。SLM样品具有可逆的马氏体相变(T0=171℃),而PM样品没有形状记忆效应。 | Dennis GERA Jonadabe SANTOS Cláudio SKIMINAMI Piter GARGARELLA | 2020 | Transactions of Nonferrous Metals Society of China2020，30，12： | 4 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 4 | Dietary approach in the treatment of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome(MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis(NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. | Silvia Marinho Ferolla Luciana Costa Silva Maria de Lourdes Abreu Ferrari Aloísio Sales da Cunha Flaviano dos Santos Martins Cláudia Alves Couto Teresa Cristina Abreu Ferrari | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 5 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 6 | Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors显示文摘Helicobacter pylori(H.pylori)is a Gram-negative bacterium that infects about half of the world's population.H.pylori infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged H.pylori infection.In this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene expression.This function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial infections.Recent discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of H.pylori,including the oncoprotein CagA.Notably,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of CagA.In addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients without.With that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of H.pylori and the potential clinical repercussions of this modulation. | Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2022 | World Journal of Clinical Cases2022，10，31： | 2 |
| 7 | Al_2O_3负载Cu,Fe或Ni掺杂氧化钼催化乙苯氧化脱氢(英文)显示文摘Molybdenum-based catalysts supported on Al_2O_3 doped with Ni, Cu, or Fe oxide were synthesized and used in ethylbenzene dehydrogenation to produce styrene. The molybdenum oxide was supported using an unconventional route that combined the polymeric precursor method(Pechini) and wet impregnation on commercial alumina. The samples were characterized by X-ray diffraction(XRD), N_2 adsorption-desorption isotherms, temperature-programmed reduction of H_2(H_2-TPR),and thermogravimetric(TG) analysis. XRD results showed that the added metals were well dispersed on the alumina support. The addition of the metal oxide(Ni, Cu, or Fe) of 2 wt% by wet impregnation did not affect the texture of the support. TPR results indicated a synergistic effect between the dopant and molybdenum oxide. The catalytic tests showed ethylbenzene conversion of 28%–53% and styrene selectivity of 94%–97%, indicating that the addition of the dopant improved the catalytic performance, which was related to the redox mechanism. Molybdenum oxides play a fundamental role in the oxidative dehydrogenation of ethylbenzene to styrene by its redox and acid–base properties. The sample containing Cu showed an atypical result with increasing conversion during the reaction, which was due to metal reduction. The Ni-containing solid exhibited the highest amount of carbon deposited, shown by TG analysis after the catalytic test, which explained its lower catalytic stability and selectivity. | Tiago Pinheiro Braga Ant?nio Narcísio Pinheiro Edson R.Leite Regina Cláudia R.dos Santos Antoninho Valentini | 2015 | 催化学报2015，36，5： | 2 |
| 8 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum‐/xeno‐free culture media显示文摘 | Irina N. Sim?es Joana S. Boura Francisco dos Santos Pedro Z. Andrade Carla M. P. Cardoso Jeffrey M. Gimble Cláudia L. da Silva Joaquim M. S. Cabral | 2013 | Biotechnology Journal2013，，4： | 1 |
| 9 | Delayed replantation of rat teeth after use of reconstituted powdered milk as a storage medium显示文摘 | dos Santos CL Sonoda CK Poi WR | | 0，，01： | 1 |
| 10 | Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue显示文摘 | Leandro Luongo de Matos Gabriel Manfro Ricardo Vieira dos Santos Elaine Stabenow Evandro Sobroza de Mello Venancio Avancini F. Alves Fábio Roberto Pinto Marco Aurélio Vamondes Kulcsar Lenine Garcia Brand?o Cláudio Roberto Cernea | 2014 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2014，，： | 1 |
| 11 | A comparison of cabergoline and bromocriptine on the risk of valvular heart disease inc patients with prolactinomas显示文摘 | Boguszewski CL dos Santos CM Sakamoto KS | 2012 | Pituitary2012，15，1： | 1 |
| 12 | Effect of Moringa oleifera lectins on survival and enzyme activities of Aedes aegypti larvae susceptible and resistant to organophosphate显示文摘 | Afonso Cordeiro Agra-Neto Thiago Henrique Napole?o Emmanuel Viana Pontual Nataly Diniz Lima Santos Luciana Andrade Luz Cláudia Maria Fontes Oliveira Maria Alice Varjal Melo-Santos Luana Cassandra Breitenbach Barroso Coelho Daniela Maria Amaral Ferraz Nava | 2014 | Parasitology Research2014，，1： | 1 |
| 13 | Metastatic thy- roid carcinoma arising from congenital goiter due to mutation in the thyroperoxidase gene 显示文摘 | Medeiros-Neto GA Gil-D-Costa M J Santos CL | 1998 | J Clin Endocrinol Metab1998，83，11： | 1 |
| 14 | Isoflurane-loaded nanoemulsion prepared by high-pressure homoge-nization:investigation of stability and dose reduction ingeneral anesthesia显示文摘 | Krahn CL Raffin RP Santos GS | 2012 | J Biomed Nanotechnol2012，8，5： | 1 |
| 15 | A Review on the applications of portable near-infrared spectrometers in the agro-food industry显示文摘 | Cláudia A Teixeira dos Santos Miguel Lopo Ricardo N M J Páscoa | 2013 | Applied Spectroscopy2013，67，11： | 1 |
| 16 | Human mesenchymal stem cell expression program upon extended ex-vivo cultivation,as revealed by 2-DE-Based q Quantitative proteomics显示文摘 | Madeira A da Silva CL dos Santos F | 2012 | Plos One2012，7，43： | 1 |
| 17 | White coat effect is not associated with additional increase of target organ damage in true resistant hypertension显示文摘 | Valéria Nasser Figueiredo Luiz Cláudio Martins Leandro Boer-Martins Ana Paula Cabral de Faria Carolina de Haro Moraes Rodrigo Cardoso Santos Armando R. Nogueira Heitor Moreno | 2012 | Medicina Clinica2012，，： | 1 |
| 18 | Anthelmintic efficacy and management practices in sheep farms from the state of Rio de Janeiro, Brazil显示文摘 | Daniela Guedes da Cruz Letícia Oliveira da Rocha Sabrina Santos Arruda Jorge Guilherme Bergottini Palieraqui Rudymilla Cunha Cordeiro Edizio Santos Marcelo Beltr?o Molento Clóvis de Paula Santos | 2010 | Veterinary Parasitology2010，，3： | 1 |
| 19 | Fatal pneumonia due to influenza virus infection diagnosed by conventional and real - time PCR from blood postmortem specimen 显示文摘 | de Paiva TM Saggioro F Santos CL | 2012 | J Clin Virol2012，55，1： | 1 |
| 20 | Human Herpesvirus-8 Oral Shedding in Amerindian Populations in the Brazilian Amazon Region显示文摘 | Laura Masami Sumita Wilton Santos Freire Mariana Quiroga Maria Cristina D.S. Fink Cynthia L.M. Canto Tania Regina Tozetto Mendoza Paulo Henrique Braz Silva Cláudio Sérgio Pannuti | 2015 | Oral Surgery, Oral Medicine, Oral Pathology and O2015，，： | 1 |
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