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| 1 | 无先兆偏头痛患者颈内静脉血中的促炎细胞因子、黏附分子和淋巴细胞整合素在头痛发作时的表达显示文摘Objective. -The aim of the present research was to verify the levels of the soluble adhesion molecules sL-and sE-selectins, intercellular adhesion molecule (sICAM)-1, and vascular cell adhesion molecule-1 in serial samples of internal jugular venous blood taken from migraine patients without aura (MWoA) during attacks. The expression of leukocyte function antigen (LFA)-1 and very late activation antigen (VLA)-4 was also assessed on lymphocytes obtained from jugular venous blood. Levels of certain proinflammatory cytokines (tumor necrosis factor-α[TNF-α], interleukin-1β[IL-1β], IL-4, and IL6) were also determined and correlated with those of adhesion molecules. Patients and Methods. -Seven MWoA patients were admitted in the hospital during attacks and blood samples were taken immediately after catheter insertion, at 1, 2, and 4 hours after attack onset, and within 2 hours after its termination. The levels of adhesion molecules and cytokines were measured with ELISA method. The expression of LFA-1 and VLA-4 was assessed by flow cytometry. Results. -A parallel transient increase of sICAM-1, TNF-α, and IL-6 was observed in the first 2 hours after attack onset compared with the time of catheter insertion (P< .0001, < .001, and < .003, respectively). The proportion of CD4+and CD8+T-cells expressing high levels of LFA-1 showed instead a progressive down-regulation with significantly lower percentages at 2 and 4 hours after attack onset (P < .01 and < .022, respectively). No variation in the percentage of VLA-4 expressing cells was observed at any time of the study. Conclusions. -The transient increase in sICAM-1 and TNF-αfound in the internal jugular blood of MWoA patients assessed ictally can be induced by sensory neuropeptides released from activated trigeminal endings. The progressive decrease in sICAM-1 levels during attacks and the down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks. | Sarchielli P. Alberti A. Baldi A. 张慧(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 5 |
| 2 | Different cytokine levels in thrombolysis patients as predictors for clinical outcome显示文摘 | Mazzotta G Sarchielli P Caso V | 2004 | Eur J Neurol2004，11，： | 1 |
| 3 | Vasoactive peptide levels in theplasma of young migraine patients with and without aura assessed bothinterictally and ictally显示文摘 | Gallai V Sarchielli P Floridi A | 1995 | Cephalalgia1995，15，5： | 1 |
| 4 | Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells显示文摘 | Borgogni E Sarchielli E Sottili M | 2008 | Endocrinology2008，149，： | 1 |
| 5 | Involvement of corti-cotrophin-releasing factor and orexin-A in chronic migraine and medi-cation-overuse headache:findings from cerebrospinal fluid显示文摘 | Sarchielli P Rainero I Coppola F | 2008 | Cephalal-gia2008，28，7： | 1 |
| 6 | Involvement ofcorticotrophin-releasing factor and orexin-A in chronicmigraine and medication-overuse headache: Findings fromcerebrospinal fluid 显示文摘 | Sarchielli P Rainero I Coppola F | 2008 | Cephalalgia2008，28，7： | 1 |
| 7 | Absolute quantification of brain metabtiles by Proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients显示文摘 | P Sarchielli OPresciutti | 1999 | Brain1999，122，3： | 1 |
| 8 | Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients 显示文摘 | Sarchielli P Alberti A Floridi A | 2001 | Neurology2001，57，1： | 1 |
| 9 | Chemokine levels inthe jugular venous blood of migraine without aura patients dur-ing attacks显示文摘 | Sarchielli P Alberti A Vaianella L | 2004 | Headache2004，44，10： | 1 |
| 10 | Chemokine levels in thejugular venous blood of migraine without aura patients duringattacks显示文摘 | Sarchielli P Alberti A Vaianella L | 2004 | Headache2004，44，10： | 1 |
| 11 | Cold single-strand conformation polymorphism analysis:optimization for detection of APC gene mutations in patients with familial Adenomatous polyposis显示文摘 | Strippoli P Sarchielli S Santucci R | 2001 | Int J Mol Med2001，8，5： | 1 |
| 12 | Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cell of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids显示文摘 | GALLAI V SARCHIELLI P TREQUATTRINI A | 1993 | Journal of Neuroimmunology1993，56，： | 1 |
| 13 | Nitric oxide in primary headaches显示文摘 | Virgilio Gallai Paola Sarchielli | 2000 | Headache Pain2000，1，： | 1 |
| 14 | Nutritional and immunological status of COPD patients显示文摘 | Dottorrini A Sarchielli P Argentati A | 1990 | Am Rev Respir Dis1990，141，： | 1 |
| 15 | Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks显示文摘 | Sarchielli P Alberti A Coppola F | 2004 | Cephalalgia2004，24，8： | 1 |
| 16 | Plasma cytochine levels in patients with obstructive sleep apnea syndrome:a preliminary study显示文摘 | Alberti A Sarchielli P Gallinella E | 2003 | J Sleep Res2003，12，： | 1 |
| 17 | Proinflammatory cytokines,adhesion molecules,and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally显示文摘 | Sarchielli P Alberti A Baldi A | 2006 | Headache2006，46，2： | 1 |
| 18 | Functional ^1H-MRS Findings in Migraine Patients with and without Aura Assessed Interictally显示文摘 | Sarchielli P Tarducci R Presciutti O | 2005 | Neurolmage2005，24，4： | 1 |
| 19 | Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study显示文摘 | Alberti A Sarchielli P Gallinella E | 2003 | J Sleep Res2003，12，4： | 1 |
| 20 | Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit显示文摘 | VIGNOZZI L MORELLI A SARCHIELLI E | 2012 | J Endocrinol2012，212，1： | 1 |
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