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| 1 | Validation of glaucoma-like features in the rat episcleral vein cauterization model显示文摘 | Bai Yujing Zhu Yingting Chen Qin Xu Jing Marinko V. Sarunic Uri H. Saragovi Zhuo Yehong | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 2 | Laparoscopic surgery for early gallbladder carcinoma:A systematic review and meta-analysis显示文摘BACKGROUND There is a controversy as to whether laparoscopic surgery leads to a poor prognosis compared to the open approach for early gallbladder carcinoma (GBC)We hypothesized that the laparoscopic approach is an alternative for early GBC.AIM To identify and evaluate the safety and feasibility of laparoscopic surgery in the treatment of early GBC.METHODS A comprehensive search of online databases,including MEDLINE (PubMed),Cochrane libraries,and Web of Science,was performed to identify noncomparative studies reporting the outcomes of laparoscopic surgery and comparative studies involving laparoscopic surgery and open surgery in early GBC from January 2009 to October 2019.A fixed-effects meta-analysis was performed for 1-and 5-year overall survival and postoperative complications,while 3-year overall survival,operation time,blood loss,the number of lymph node dissected,and postoperative hospital stay were analyzed by random-effects models.RESULTS The review identified 7 comparative studies and 8 non-comparative studies.1068 patients (laparoscopic surgery:613;open surgery:455) were included in the meta-analysis of 1-,3-,and 5-year overall survival with no significant differences observed [(HR=0.54;95%CI:0.29-1.00;12=0.0%;P=0.051),(HR=0.75;95%CI:0.34-1.65;I^2=60.7%;P=0.474),(HR=0.71;95%CI:0.47-1.08;I^2=49.6%;P=0.107),respectively].There were no significant differences in operation time[weighted mean difference (WMD)=18.69;95%CI:-19.98-57.36;I^2=81.4%;P=0.343],intraoperative blood loss (WMD=-169.14;95%CI:-377.86-39.57;I2=89.5%;P=0.112),the number of lymph nodes resected (WMD=0.12;95%CI:-2.95-3.18;I^2=73.4%;P=0.940),and the complication rate (OR=0.69;95%CI:0.30-1.58;I2=0.0%;P=0.377) between the two groups,while patients who underwent laparoscopic surgery had a reduced length of hospital stay (WMD=-5.09;95%CI:-8.74--1.45;I2=91.0%;P=0.006).CONCLUSION This systematic review and meta-analysis confirms that laparoscopic surgery is a safe and feasible alternative to open surgery with comparable survival and operation-related outcomes for early GBC. | Xu Feng Jia-Sheng Cao Ming-Yu Chen Bin Zhang Sarun Juengpanich Jia-Hao Hu Win Topatana Shi-Jie Li Ji-Liang Shen Guang-Yuan Xiao Xiu-Jun Cai Hong Yu | 2020 | World Journal of Clinical Cases2020，8，6： | 6 |
| 3 | 2013至2015年浙江地区人感染 H7 N9禽流感病毒蛋白关键位点分子特征分析显示文摘目的:分析浙江地区人感染H7 N9禽流感病毒的分子特征,为更好地预防与治疗人感染H7N9禽流感提供科学依据。方法从全球禽流感共享数据库(GISAID)中下载浙江地区2013至2015年分离的人感染H7N9病毒株(共30株)和同时期禽源性病毒株(15株)的基因序列,运用MEGA 6.0软件比较分析人H7N9流感病毒基因的分子进化特征、受体结合位点、毒力相关位点、耐药性位点的变异情况。结果进化树分析显示,浙江地区人感染H7 N9代表株与禽源性参考株的HA、NA蛋白差异较小,同源性分别为98.0%~100.0%和97.4%~100.0%。病毒氨基酸变异分析显示,30株H7N9代表株的HA蛋白均发生了226位( Q226L/I)和186位( G186V)突变,且2015年分离株出现A134V突变;有1株NA蛋白出现R294K耐药位点的变异;19株PB2蛋白发生了E627K突变,2株发生D701N突变;所有代表株M2蛋白均发生了S31N突变;HA的裂解位点均为PEIPKGR↓GLF,仍为低致病性毒株。结论2013至2015年浙江地区人感染H7N9流感病毒与同时期的禽源性病毒株具有高度同源性,部分氨基酸位点存在变异,所有代表株对离子通道抑制剂(金刚烷胺类药物)耐药,个别菌株出现对神经氨酸酶抑制剂(奥司他韦)耐药。 | 孙海燕 童海江 崔大伟 Juengpanich Sarun Pimpakan Aojanepong | 2016 | 中华临床感染病杂志2016，9，4： | 4 |
| 4 | Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma显示文摘BACKGROUND Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has improved overall survival (OS) in patients with hepatocellular carcinoma (HCC).However,the prognostic and predictive factors remain unclear.AIM To assess the prognostic factors and the predictors of PA-TACE benefit for OS in patients with resected HCC.METHODS Univariate and multivariate analyses were performed to identify the potential prognostic factors for OS.In order to assess the predictive factors of PA-TACE benefit,the interaction variables between treatments for each subgroup were evaluated using the Cox proportional hazards regression model.RESULTS A total of 378 patients (PA-TACE vs surgery alone,189:189) from three centerswere included after a propensity-score 1:1 matching analysis.Compared to the group receiving surgery alone,PA-TACE prolonged the OS rate in patients with resected HCC (P <0.001).The Barcelona Clinic Liver Cancer system and ferritinto-hemoglobin ratio (FHR) were used as the prognostic factors for OS in both groups.Age (P=0.023) and microscopic vascular invasion (MVI)(P=0.002) were also identified in the PA-TACE group,while gender (P=0.027),hepatitis B virus(P=0.034) and albumin-bilirubin grade (P=0.027) were also selected in the surgery alone group.In addition,PA-TACE resulted in longer OS than surgery alone across subgroups [all hazard ratios (PA-TACE-to-surgery alone)<1].Notably,a significantly prolonged OS following PA-TACE was observed in patients with high FHR (P=0.038) and without MVI (P=0.048).CONCLUSION FHR and Barcelona Clinic Liver Cancer stages were regarded as prognostic factors for OS.Moreover,high FHR and the absence of MVI were important predictive factors,which can be used to assist clinicians in selecting which patients could achieve a better OS with PA-TACE. | Ming-Yu Chen Sarun Juengpanich Jia-Hao Hu Win Topatana Jia-Sheng Cao Chen-Hao Tong Jian Lin Xiu-Jun Cai | 2020 | World Journal of Gastroenterology2020，26，10： | 4 |
| 5 | Promising key genes associated with tumor microenvironments and prognosis of hepatocellular carcinoma显示文摘BACKGROUND Despite significant advances in multimodality treatments,hepatocellular carcinoma(HCC)remains one of the most common malignant tumors.Identification of novel prognostic biomarkers and molecular targets is urgently needed.AIM To identify potential key genes associated with tumor microenvironments and the prognosis of HCC.METHODS The infiltration levels of immune cells and stromal cells were calculated and quantified based on the ESTIMATE algorithm.Differentially expressed genes(DEGs)between high and low groups according to immune or stromal scores were screened using the gene expression profile of HCC patients in The Cancer Genome Atlas and were further linked to the prognosis of HCC.These genes were validated in four independent HCC cohorts.Survival-related key genes were identified by a LASSO Cox regression model.RESULTS HCC patients with a high immune/stromal score had better survival benefits than patients with a low score.A total of 899 DEGs were identified and found to be involved in immune responses and extracellular matrices,147 of which were associated with overall survival.Subsequently,52 of 147 survival-related DEGs were validated in additional cohorts.Finally,ten key genes(STSL2,TMC5,DOK5,RASGRP2,NLRC3,KLRB1,CD5L,CFHR3,ADH1C,and UGT2B15)were selected and used to construct a prognostic gene signature,which presented a good performance in predicting overall survival.CONCLUSION This study extracted a list of genes associated with tumor microenvironments and the prognosis of HCC,thereby providing several valuable directions for the prognostic prediction and molecular targeted therapy of HCC in the future. | Long Pan Jing Fang Ming-Yu Chen Shu-Ting Zhai Bin Zhang Zhi-Yu Jiang Sarun Juengpanich Yi-Fan Wang Xiu-Jun Cai | 2020 | World Journal of Gastroenterology2020，26，8： | 4 |
| 6 | Artificial intelligence in gastroenterology and hepatology:Status and challenges显示文摘Originally proposed by John McCarthy in 1955,artificial intelligence(AI)has achieved a breakthrough and revolutionized the processing methods of clinical medicine with the increasing workloads of medical records and digital images.Doctors are paying attention to AI technologies for various diseases in the fields of gastroenterology and hepatology.This review will illustrate AI technology procedures for medical image analysis,including data processing,model establishment,and model validation.Furthermore,we will summarize AI applications in endoscopy,radiology,and pathology,such as detecting and evaluating lesions,facilitating treatment,and predicting treatment response and prognosis with excellent model performance.The current challenges for AI in clinical application include potential inherent bias in retrospective studies that requires larger samples for validation,ethics and legal concerns,and the incomprehensibility of the output results.Therefore,doctors and researchers should cooperate to address the current challenges and carry out further investigations to develop more accurate AI tools for improved clinical applications. | Jia-Sheng Cao Zi-Yi Lu Ming-Yu Chen Bin Zhang Sarun Juengpanich Jia-Hao Hu Shi-Jie Li Win Topatana Xue-Yin Zhou Xu Feng Ji-Liang Shen Yu Liu Xiu-Jun Cai | 2021 | World Journal of Gastroenterology2021，27，16： | 3 |
| 7 | Quantitative evaluation of transform domains for compressive sampling-based recovery of sparsely sampled volumetric OCT images 显示文摘 | Wu A B Burnaby B C Sarunic M V | 2012 | IEEE Transactions on Biomedical Engineering2012，60，2： | 1 |
| 8 | Sensitivity advantage of swept source and Fourier domain optical coherence tomography 显示文摘 | Chorea M Sarunic M Yang C | 2003 | Opt Express2003，11，18： | 1 |
| 9 | Sensitivity advantage of swept source and Fourier domain optical coherence tomography显示文摘 | ChomaM A Sarunic M V Yang C H | 2003 | Opt Express2003，11，18： | 1 |
| 10 | A novel low temperature synthesis rout for SmFeAsOl-z F, bulk super- conductor with improved transport properties显示文摘 | Anooja J B Aswathy P M Sarun P M | 2012 | J Alloy Compd2012，514，： | 1 |
| 11 | An overview on iron based superconductors显示文摘 | P M Aswathy J B Anooja P M Sarun U Syamaprasad | 2010 | Superconductor Science and Technology2010，，7： | 1 |
| 12 | Highly enhanced superconducting properties of Eu-doped (Bi,Pb)-2212显示文摘 | SARUN P M VINU S SHABNA R | 2008 | Mater Lett2008，62，1718： | 1 |
| 13 | Spectral domain second-harmonic optical coherence tomography 显示文摘 | Sarunic MV Applegate BE Izatt JA | 2005 | Opt Lett2005，30，18： | 1 |
| 14 | Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland显示文摘 | Hombach-Klonisch S Buchmann J Sarun S | 2000 | Cancer2000，89，： | 1 |
| 15 | Sensitivity advantage of swept source and Fourier domain optical coherence tomography显示文摘 | Choma M Sarunic M Yang C | 2003 | Opt Express2003，11，18： | 1 |
| 16 | Sensitivity advantage of swept source and Fourier domain optical coherence tomography显示文摘 | Choma MA Sarunic MV Yang CH | 2003 | Opt Express2003，11，： | 1 |
| 17 | Increase of lifespan forglioma-bearing rats by using minibeam radiation therapy显示文摘 | Prezado Y Sarun S Gil S | 2012 | J Synchrotron Radiat2012，19，： | 1 |
| 18 | Instantaneous complex conjugate resolved spectral domain and swept-source OCT using 3x3 fiber couplers 显示文摘 | Sarunic M Choma M A Yang C | 2005 | Optics Express(S1094-4087)2005，13，3： | 1 |
| 19 | Exploaration of preferred learning styles in medical education using VARK modal 显示文摘 | Laxman K Sandip S Sarun K | 2014 | Russian Open Medical Journal2014，8，305： | 1 |
| 20 | Field test studies of our infrared-based human temperature screening system embedded with a parallel measurement approach 显示文摘 | Sarun Sumriddetchkajorn Kosom Chaitavon | 2009 | Infrared Physics Technology2009，52，4： | 1 |
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