|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model显示文摘AIM:To investigate the impact of dietary copper given at different time points on the onset of fulminant hepatitis. METHODS:The Long-Evans cinnamon (LEC) rat model of Wilson's disease (WD) was used to study the impact of high dietary copper (hCu) on the induction of fulminant hepatitis at early or late time points of life. High Cu diet was started in rat pups or in adults (month 5) for three months. Animals that received reduced dietary copper (rCu) throughout their lifetime served as a control. Hepatitis-associated serum markers (alanine aminotransferase, aspartate transaminase, bilirubin) were analyzed in animal groups receiving hCu or rCu. Liver copper content and liver histology were revealed at sacrifice. A set of 5 marker genes previously found to be affected in injured liver and which are related to angiogenesis (Vegfa), fat metabolism (Srebf1), ex-tracellular matrix (Timp1), oxidative stress (Hmox1), and the cell cycle (Cdkn1a) were analyzed by real-time polymerase chain reaction. RESULTS:Regardless of the time point when hCu was started, LEC rats (35/36) developed fulminant hepatitis and died. Animals receiving rCu (36/36) remained healthy, did not develop hepatitis, and survived long term without symptoms of overt disease, although liver copper accumulated in adult animals (477 ± 75 μg/g). With regard to start of hCu, onset of fulminant hepatitis was significantly (P < 0.001) earlier in adults (35 ± 9 d) that showed pre-accumulation of liver copper as compared to the pup group (77 ± 15 d). Hepatitis-associated serum markers, liver copper and liver histology, as well as gene expression, were affected in LEC rats receiving hCu. However, except for early and rapid onset of hepatitis, biochemical and molecular markers were similar at the early and late time points of disease. CONCLUSION:Rapid onset of fulminant hepatitis in asymptomatic LEC rats with elevated liver copper suggests that there is a critical threshold of liver copper which is important to trigger the course of WD. | Ramsi Siaj Vanessa Sauer Sandra Stppeler Hans-Ullrich Spiegel Gabriele Khler Andree Zibert Hartmut HJ Schmidt | 2012 | World Journal of Gastroenterology2012，18，39： | 3 |
| 2 | AP-1 proteins mediate hyperglycemia - induced activation of the human TGF- betal promoter in mesangial cells显示文摘 | Weigert C Sauer U Brodbeck K | 2000 | J Am Soc Nephrol2000，11，11： | 1 |
| 3 | An economic evaluation of the Moneyball hypothesis显示文摘 | HAKES J K SAUER R D | 2006 | The Journal of Econom- ic Perspectives2006，20，3： | 1 |
| 4 | lnterproximal biofilm removal by intervallie use of a sonic toothbrush compared to an oral irrigation system显示文摘 | Tawakoli PN Sauer B Becker K | 2015 | BMC Oral Health2015，15，： | 1 |
| 5 | Reduction of secondary flow lossed in turbine cascades by leading edge modifications at the endwall 显示文摘 | Sauer H Mailer R Vogeler K | 2001 | Journal of Turbomachinery2001，123，2： | 1 |
| 6 | Ultrasound-guided large-core needle biopsies of breast lesions: analysis of 962 cases to determine the number of samples for reliable tumour classification显示文摘 | Sauer G Deissler H Strunz K | 2005 | British Journal of Cancer2005，92，2： | 1 |
| 7 | Effect of phytase supplementation to diets for weanling pigs on the digestibilities of chide proteins,amino acids,and energy显示文摘 | Liao S F Sauer W C Kies A K | 2005 | J Anim Sci2005，83，： | 1 |
| 8 | IL-21 is required to control chronic viral infection显示文摘 | Elsaesser H Sauer K Brooks DG | 2009 | Science2009，324，5934： | 1 |
| 9 | Fatigue performance of ultra-high-molecular-weight polyethylene - effect of gamma-radiation sterilization显示文摘 | Sauer W L Weaver K D Beals N B | 1996 | Biomaterials1996，17，20： | 1 |
| 10 | Approximate Methods for Analyzing Queueing Network Models of Computing System 显示文摘 | Chandy K M Sauer C H | 1978 | Computing Surveys1978，，6： | 1 |
| 11 | EGFR gene copy number heterogeneity in fine-needle aspiration cytology from breast carcinomas determined by chromogenic in situ hybridization显示文摘 | Sauer T Beraki K Noren T | 2005 | Diagn Cytopathol2005，33，4： | 1 |
| 12 | A holistic aging model for Li(NiMnCo)O 2 based 18650 lithium-ion batteries显示文摘 | Johannes Schmalstieg Stefan K?bitz Madeleine Ecker Dirk Uwe Sauer | 2014 | Journal of Power Sources2014，，： | 1 |
| 13 | Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm显示文摘 | SAUER K CAMPER A K EHRLICH G D | 2008 | J Bacteriol2008，184，4： | 1 |
| 14 | IL-21 is re- quired to control chronic viral in{ection显示文摘 | Elsaesser H Sauer K Brooks DG | 2009 | Science2009，324，5934： | 1 |
| 15 | IL-21 is required to control chron- ic viral infection 显示文摘 | Elsaesser H Sauer K Brooks DG | 2009 | Science2009，324，5934： | 1 |
| 16 | Evaluation of the 5N-isotope dilution technique for determiningthe recovery of endogenous protein in ileal digesta of pigs : effect of the pattern of blood sampling, precursor pools, and isotope dilution technique 显示文摘 | LIEN K A SAUER W C DUGAN M E R | 1997 | Journal of Animal Science1997，75，1： | 1 |
| 17 | Effectof dietary protein content on ileal amino acid digesti-bility ,growth performance,and formation of microbialmetabolites in ileal and cecal digesta of early-weanedpigs显示文摘 | HTOO J K’ARAIZA B A SAUER W C | 2007 | Journal of Animal Science2007，85，12： | 1 |
| 18 | MRI mismatch-based intravenous thrombolysis for isolated cerebellar infarction显示文摘 | K(o)hrmann M Sauer R Huttner HB | | 0，，05： | 1 |
| 19 | E- valuation of the SN-isotope dilution technique for de- termining the recovery of endogenous protein in ileal digestion of pigs: effect of dilution in the precursor pool for endogenous nitrogen secretion 显示文摘 | LIEN K A SAUER W C MOSENTHIN R | 1997 | Journal of Animal Science1997，75，1： | 1 |
| 20 | A three-dimensional statistical approach to improved image quality for multislice helical CT显示文摘 | Thibault J B Sauer K D Bouman C A | 2007 | Med Phys2007，34，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员