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| 1 | Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM: To critically appraise the published randomized, controlled trials on the prophylactic effectiveness of the non-steroidal anti-inflammatory drugs(NSAIDs), in reducing the risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis. METHODS: A systematic literature search(MEDLINE, Embase and the Cochrane Library, from inception of the databases until May 2015) was conducted to identify randomized, clinical trials investigating the role of NSAIDs in reducing the risk of post-ERCP pancreatitis. Random effects model of the meta-analysis was carried out, and results were presented as odds ratios(OR) with corresponding 95%CI.RESULTS: Thirteen randomized controlled trials on 3378 patients were included in the final meta-analysis. There were 1718 patients in the NSAIDs group and 1660 patients in non-NSAIDs group undergoing ERCP. The use of NSAIDs(through rectal route or intramuscular route) was associated with the reduced risk of post-ERCP pancreatitis [OR, 0.52(0.38-0.72), P = 0.0001]. The use of pre-procedure NSAIDs was effective in reducing approximately 48% incidence of post-ERCP pancreatitis, number needed to treat were 16 with absolute risk reduction of 0.05. But the risk of post-ERCP pancreattis was reduced by 55% if NSAIDs were administered after procedure. Similarly, diclofenac was more effective(55%) prophylactic agent compared to indomethacin(41%).CONCLUSION: NSAIDs seem to have clinically proven advantage of reducing the risk of post-ERCP pancreatitis. | Muhammad S Sajid Amir H Khawaja Mazin Sayegh Krishna K Singh Zinu Philipose | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 14 |
| 2 | Costimulation couture: a designer approach to regulating autoimmunity 显示文摘 | ANSARI M J SAYEGH M H | 2006 | J Clin Invest2006，116，8： | 1 |
| 3 | Antibody induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes 显示文摘 | Hancock W W Buelow R Sayegh M H | 1998 | Nat Med1998，12，： | 1 |
| 4 | Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis显示文摘 | Ratziu V Bonyhay L Di Martino V Charlotte F Cavallaro L Sayegh Tainturier M H | 2002 | Hepatology2002，35，： | 1 |
| 5 | Thymic recognition of class Ⅱ major histocompatibility complex allopeptide induces donor-speeific unresponsiveness to renal allografts显示文摘 | Sayegh M H Perico N Imberti O | 1993 | Transplantation1993，56，： | 1 |
| 6 | Immunomodulatory functions of mesenchyreal stem cells显示文摘 | Frank M H Sayegh M H | 2004 | Lancet2004，363，9419： | 1 |
| 7 | Efficient antibody diversification by gene conversion in vivo in the absence of selection for V (D) J-encoded determinants 显示文摘 | Sayegh C E Drury G Ratcliffe M J H | 1999 | EMBOJ1999，18，22： | 1 |
| 8 | Evidence of enhanced vascular superoxide anion production in nitrate tolerance:a novel mechanism underlying tolerance and cross-tolerance 显示文摘 | Munzel T Sayegh H Freeman BA | 1995 | J Clin Invest1995，95，1： | 1 |
| 9 | The CD154-CD40 costimulatory pathway in transplantation显示文摘 | Akira Y A Sayegh M H | 2002 | Transplantation2002，73，1： | 1 |
| 10 | Role of novel T-cell costimulatory pathways in transplantation显示文摘 | MANDELBROT D A SAYEGH M H | 2003 | Curr Opin Organ Transplantation2003，8，： | 1 |
| 11 | Manipulation of death pathways in desmin-related cardiomyopathy显示文摘 | Maloyan A Sayegh J Osinska H | 2010 | Cite Res2010，106，： | 1 |
| 12 | Maternal acceptance of the fetus: true human tolerance 显示文摘 | Guleria l Sayegh M H | 2007 | J Immunol2007，187，： | 1 |
| 13 | Negative T-cell cos- timulatory pathways: their role in regulating alloimmune responses 显示文摘 | BOENISCH O SAYEGH M H NAJAF1AN N | 2008 | Curr Opin Organ Transplant2008，13，4： | 1 |
| 14 | Delayed graft function in kidney transplantation显示文摘 | PERICO N CATTANEO D SAYEGH M H | 2004 | Lancet2004，364，9447： | 1 |
| 15 | Quantifying the frequency of alloreactive T cells in vivo:new answers to an old question显示文摘 | Suchin E J Langmuir P B Palmer E Sayegh M H Wells A D Turka L A | 2001 | J Immunol2001，166，： | 1 |
| 16 | lmmunomodulatory functions of mesenchymal stem cells显示文摘 | Frank M H Sayegh M H | 2004 | Lancet2004，363，9419： | 1 |
| 17 | Immunosuppressive strategies in transplantation 显示文摘 | DENTON M D MAGEE C C SAYEGH M H | 1999 | Lancet1999，353，9158： | 1 |
| 18 | New roentgenologic signs of carcinoma of the ureter显示文摘 | Bergman H Friedenberg RM Sayegh V | 1961 | AJR1961，86，： | 1 |
| 19 | A Quasi lattice - local composition model for the excess gibbs free energy of liquid mixtures 显示文摘 | VERA J H SAYEGH S G RATCLIFF G A | 1977 | Fluid Phase Equilibria1977，1，： | 1 |
| 20 | Regulation of expression of the endothelial cell nitric oxide synthase显示文摘 | Sayegh H Ohara Y | 1996 | Clin Exp Pharmacol Physiol1996，23，3： | 1 |
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