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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The ramsey numbers R(C7, C7, C7)显示文摘 | Faudree R J Schelten A Schiermeyer I | 2003 | Discussiones Mathematicae Graph Theory2003，23，1： | 1 |
| 3 | The Ramsey number R(C7,C7,C7)显示文摘 | FAUDREE R J SCHELTEN A SCHIERMEYER I | 2003 | Discuss Math Graph Theory2003，23，1： | 1 |
| 4 | Thalamic lesions in vascular dementia: low sensitivity of fluid-attenuated inversion recovery (flair) imaging 显示文摘 | Bastos Leite A J van Straaten EC Scheltens P | 2004 | Stroke2004，35，2： | 1 |
| 5 | MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer,s disease显示文摘 | Barber R Gholkar A Scheltens P | 2000 | Int J Geriatr Psychiatry2000，15，： | 1 |
| 6 | Medial temporal lobe atrophy on MRI in dementia with Lewy bodies显示文摘 | Barber R Gholkar A Scheltens P | | 0，，06： | 1 |
| 7 | White matter lesions on magnetic resonance imaging in dementia with Lewy bodies,Alzheimer's disease,vascular dementia,and normal aging显示文摘 | Scheltens P Gholkar A | 1999 | J Neurol Neurosurg Psychiatry1999，67，： | 1 |
| 8 | White matter lesions on magnetic resonan ee imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal ag- ing显示文摘 | Barber R Scheltens P Gholkar A | 1999 | J Neurol Neurosurg Psychiatry1999，67，1： | 1 |
| 9 | MRI volumetric correlates of white matter lesions in dementia with lewy bodies and Alzheimer ' s disease显示文摘 | Barber R Gholkar A Scheltens P | 2000 | Int J Geriatr Psychiatry2000，15，： | 1 |
| 10 | Medial temporal lobeatrophy on MRI in dementia with Lewy bodies显示文摘 | Barber R Gholkar A Scheltens P | 1999 | Neurology1999，52，： | 1 |
| 11 | White matter lesions on magnetic resonance imaging i n dementia with Lewy bodies,Alzheimer's disease,vascular dementia,and normal aging显示文摘 | Barber R Scheltens P Gholkar A | 1999 | J Neurol Neurosurg Psychiatry1999，67，1： | 1 |
| 12 | Clinical diag- nosis and brain imaging in patients attending a memory clinic 显示文摘 | BIESSELS G J KOFFEMAN A SCHELTENS P | 2006 | J Neurol2006，253，4： | 1 |
| 13 | White matter lesions on magnetic resonance imaging in dementia with Lewy bodies,Alzheimer's disease,vascular dementia,and normal aging显示文摘 | Barber R Scheltens P Gholkar A | 1999 | J Neurol Neurosurg Psychiatry1999，67，： | 1 |
| 14 | Histopatho logic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis显示文摘 | Van Walderveen M A Kamphorst W Scheltens P | 1998 | Neurology1998，50，： | 1 |
| 15 | How Useful Is the IQCODE for Discriminating between Alzheimer’s Disease, Mild Cognitive Impairment and Subjective Memory Complaints?显示文摘 | Sikkes Sietske A M Van Den Berg Mark T Knol Dirk L De Lange-de Klerk Elly S M Scheltens Philip Uitdehaag Bernard M J Klein Martin Pijnenburg Yolande A L | 2010 | Dementia and Geriatric Cognitive Disorders2010，，： | 1 |
| 16 | White matter lesions on magnetic resonance imaging in dementia with Lewy bodies,Alzheimer's disease,vascular dementia,and normal aging显示文摘 | Barber R Scheltens P Gholkar A | 1999 | J Neurol Neurosurg Psychiatry1999，67，： | 1 |
| 17 | Corpus callosum size correlates with asymmetric performance on a dichotic listening task in healthy aging but not in Alzheimer's disease显示文摘 | Gootjes L Bouma A Van Strien J.W Van Schijndel R Barkhof F & Scheltens P | | 0，，： | 1 |
| 18 | Diabetes and cognitive impairment: clinical diagnosis and brain imaging in patients attending a memory clinic 显示文摘 | Biessels GJ Koffeman A Scheltens P | 2006 | J Neurol2006，253，4： | 1 |
| 19 | Patients to learn from:on the need for systematic integration of research and care in academic health care显示文摘Patients suffering from rare,extreme or extremely complex sets of symptoms have something to expect from efforts to improve care through research.Biomedical research and care have often been approached as distinct worlds which are and should be only loosely connected.For observational research focusing on data drawn from real-world settings,however,that approach is found wanting.Integrating research and care responsibly is the main challenge instead.Integrated IT infrastructures facilitating Personalized medicine and Big Data are crucial components of a learning health care system,in which patients regularly play a double role:as individuals to be treated and as cases to learn from.Drawing on the example of the Dutch Parelsnoer Institute(PSI),a national biobanking and IT infrastructure integrated with clinical care procedures,this article outlines the reforms that are needed.Systematic integration of research and care offers a promising avenue,provided that a number of conditions are met:data and IT infrastructures will require overhauls in order to facilitate secure,high-quality data integration between research and care;institutional focus is needed to bring patient populations and expertise together;ethical frameworks and approaches for integrating research and care responsibly require further elaboration;clinical procedures and professional responsibilities may need to be adapted in order to accommodate research requirements in clinical processes;and involvement of patients and other stakeholders in design and research priority setting is needed to further the goals of real-world and patient relevance.Relevance for patients:Integrating research and care in academic medicine in a more systematic fashion offers a promising perspective to current and future patients.In order to live up to these promises,research and care should be integrated more systematically in academic health science,with patients being included as research participants by default.Data and tissue infrastructures and facilities can provide a platform for doing so.At the same time,many issues remain to be settled.New ethical ways and means for protecting and respecting patient-participants in such a double role are also needed in this respect.In this way a deeper transformation is at stake as well:a change towards a setting in which patients fully take center stage in debate and action on the future of biomedicine. | Martin Boeckhout Philip Scheltens Peggy Manders Cees Smit Annelien L Bredenoord Gerhard A Zielhuis | 2018 | Journal of Clinical & Translational Research2018，4，3： | 0 |
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