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| 1 | Maximum tolerated volume in drinking tests with water and a nutritional beverage for the diagnosis of functional dyspepsia显示文摘AIM: Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD patients and controls in a Mexican population. METHODS: Twenty FD-Rome Ⅱ patients were matched by age and gender with 20 healthy controls. All underwent both drinking tests at a 15 mL/min rate, randomly, 7 d apart. Every 5 min within each test, four symptoms were evaluated (satiety, bloating, nausea and pain) by Likert scales. Maximum tolerated volume (MTV) was defined as the ingested volume when a score of 5 was reached for any symptom or when the test had to be stopped because the patients could not tolerate more volume. Sensitivity and specificity were analyzed. RESULTS: FD patients had higher symptom scores for both tests compared to controls (water: t= 4.1, P= 0.001 <0.01; Nutren(R): t= 5.2, P= 0.001<0.01). The MTV forwater and Nutren(R) were significantly lower in FD (water: 1014±288 vs 1749±275 mL; t = 7.9, P = 0.001<0.01;Nutren(R): 652±168 vs 1278±286 mL; t= 6.7, P = 0.001<0.01). With the volume tolerated by the controls, the percentile 10 was determined as the lower limit fortolerance. Sensitivity and specificity were 0.90, 0.95 for water and 0.95, 0.95 for Nutren(R) tests.CONCLUSION: A drinking test with water or a nutritional beverage can discriminate between FD patients and healthy subjects in Mexico, with high sensitivity and specificity. These tests could be used as objective, noninvasive, and safe diagnostic approaches for FD patients. | Aldo Montao-Loza Max Schmulson Sergio Zepeda-Gómez Jose Maria Remes-Troche Miguel Angel Valdovinos-Diaz | 2005 | World Journal of Gastroenterology2005，11，20： | 3 |
| 2 | Cytokine imbalance in irritable bowel syndrome: a systematic review and meta‐analysis显示文摘 | M. Bashashati N. Rezaei A. Shafieyoun D. P. McKernan L. Chang L. ?hman E. M. Quigley M. Schmulson K. A. Sharkey M. Simrén | 2014 | Neurogastroenterol. Motil2014，，7： | 2 |
| 3 | Gender-related differencasin IBS symptoms显示文摘 | Lee OY Mayer EA Schmulson M | 2001 | Am J Gastroenterol2001，96，： | 1 |
| 4 | Frequency of functional bowel disorders among healthy volunteers in Mexico city显示文摘 | Schmulson M Ortíz O Santiago-Lomeli M | 2006 | Dig Dis2006，24，34： | 1 |
| 5 | Correlation of symptom criteria with perception thresholds during rectosigmoid distension in irritable bowel syndrome patients 显示文摘 | Schmulson M Chang L Naliboff B | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 6 | Review article:the treatment of functional abdominal bloating and distension显示文摘 | Schmulson M Chang L | 2011 | Aliment Pharmacol Ther2011，33，10： | 1 |
| 7 | Chest pain of esophageal origin显示文摘 | Fass R Malagon I Schmulson M | 2001 | Curr Opin Gastroenterol2001，17，： | 1 |
| 8 | Chest pain of esophageal origin显示文摘 | Fass R Malagon I Schmulson M | 2001 | Curr Opin Gastroenterol2001，17，4： | 1 |
| 9 | Chest pain of esophageal origin 显示文摘 | Fass R Malagon I Schmulson M | 2001 | Curr Opin Gastroenternl2001，17，4： | 1 |
| 10 | Diagnostic approach to the patient with irritable bowel syndrome 显示文摘 | Schmulson MW Chang L | 1999 | Am J Med1999，107，5： | 1 |
| 11 | Gender related difference in IBS symptoms 显示文摘 | Lee OY Mayer EA Schmulson M | 2001 | Am J Gastroenterology2001，96，7： | 1 |
| 12 | Correlation of syndrome criteria with perception threstholds during rectosigmoid distension in Trritable bowel syndrome patients 显示文摘 | Schmulson M Chang L Naliboff B | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 13 | Gender- related differences in IBS symptoms 显示文摘 | LEE O Y MAYER E A SCHMULSON M | 2001 | Am J Gastroen- terol2001，96，7： | 1 |
| 14 | Symptom differences in moderate to severe IBS patients based on predominant bowel habit显示文摘 | Schmulson M Lee OY Chang L | | 0，，： | 1 |
| 15 | Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome: an evidence- based review显示文摘 | Schmulson M Bielsa MV Carmona-S6nchez R | 2014 | Rev Gastroenteml Mex2014，79，2： | 1 |
| 16 | Frequency of functional bowel disorders among healthy volunteers in Mexico City显示文摘 | Schmulson M Ortíz O Santiago-Lomeli M | 2006 | Dig Dis2006，24，34： | 1 |
| 17 | Symptom differences inmoderate to severe IBS patients based on predominant bowel habit显示文摘 | SCHMULSON J LEE OY CHANG L | 1999 | Am J Gastroenterol1999，94，10： | 1 |
| 18 | Gender-related differences in IBS symptoms 显示文摘 | LEE OY MAYER EA SCHMULSON M | 2001 | Am J Gastroenterol2001，96，7： | 1 |
| 19 | Gender related differences in IBS symptoms显示文摘 | Lee OY Mayer FA Schmulson M | 2001 | Am J Gastroenterol2001，96，： | 1 |
| 20 | Review article: the treatment of function- al abdominal bloating and distension显示文摘 | Schmulson M Chang L | 2011 | Aliment Pharmacol Ther2011，33，10： | 1 |
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