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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Laboratory investigations of impact-generated plasma显示文摘 | Crawford A Schultz P H | 1991 | JournalGeophysics Research1991，96，18： | 1 |
| 3 | Electromagnetic properties of impact generated plasma,vapor and debris显示文摘 | David A Crawford A Schultz P H | 1999 | International Journal of Impact Engineering1999，23，： | 1 |
| 4 | Oogenetic and zygotic gene expression directing early bovine embryogenesis 显示文摘 | De Sousa P A Watson A J Schultz G A | 1998 | Mol Reprod Dev1998，51，： | 1 |
| 5 | Prediction of chain flexibility in proteins显示文摘 | Karplus P A Schultz G E | 1985 | Immunology1985，72，2： | 1 |
| 6 | Laboratory investigations of impact-generated plasma 显示文摘 | Crawford D A Schultz P H | 1991 | J Geophys Res1991，18，： | 1 |
| 7 | Cell and Circuit Design for Single-Poly EPROM 显示文摘 | HOE D H K SCHULTZ K J SALAMA C A T HADAWAY R A KEMPF P | 1989 | IEEE Journal of Solid-state Circuits1989，24，4： | 1 |
| 8 | Fluorochemical mass flowsin a municipal wastewater treatment facility显示文摘 | Schultz M M Higgins C P Huset C A | 2006 | Environmental Scienceand Technology2006，40，23： | 1 |
| 9 | RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse显示文摘 | Balboula A Z Stein P Schultz R M | 2015 | Biol Reprod2015，92，4： | 1 |
| 10 | Fluorescence contouring analysis of DOC intercalibration experiment samples:A comparison of techniques显示文摘 | COBLE P G SCHULTZ C A MOPPER K | 1993 | Mar Chem1993，41，： | 1 |
| 11 | Prediction of chain flexibility in pro- teins显示文摘 | KARPLUS P A SCHULTZ G E | 1985 | Naturwissenschaften1985，72，4： | 1 |
| 12 | Prediction of chain flexibility in proteins显示文摘 | Karplus P A Schultz G | 1985 | Naturw-issenschaften1985，72，： | 1 |
| 13 | Electromagnetic properties of impact-generated plasma,vapor and debris显示文摘 | Schultz P H Crawford D A | | 0，，01： | 1 |
| 14 | Genetic aberrations common in gastric high-grade large B-cell lymphoma 显示文摘 | Starostik P Greiner A Schultz A | 2000 | Blood2000，95，4： | 1 |
| 15 | Prediction of chain flexibility in proteins显示文摘 | Karplus P A Schultz G E | 1985 | Naturwissenschafien1985，72，2： | 1 |
| 16 | Psychometric analysis of the Func- tional Assessment of Cancer Therapy -- GcneraI( FACT -- G) Hale in a rural sample显示文摘 | Winstead--Fry P Schultz A | 1997 | Cancer1997，79，12： | 1 |
| 17 | Load-displacement properties of lower cervical spine motion segments显示文摘 | MORONEY S P SCHULTZ A B MILLER J A A | 1988 | J Biomech1988，21，： | 1 |
| 18 | Family of gene coding for two serologically distinct chicken interferon显示文摘 | SICK C SCHULTZ U STEAHEIN P A | 1996 | Biol Chem1996，271，13： | 1 |
| 19 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 20 | Vibrotactile detection thresholds for chest skin of amputees following targeted reinnervation surgery显示文摘 | Schultz A E Marasco P D Kuiken T A | | 0，，： | 1 |
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